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Tetrodotoxin reduces cue-induced drug craving and anxiety in abstinent heroin addicts
Shi, Jie1; Liu, Ting-Ting1; Wang, Xi1; Epstein, David H.2; Zhao, Li-Yan1; Zhang, Xiao-Li1; Lu, Lin1
关键词Drug cues Heroin dependence Tetrodotoxin Craving
刊名PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
2009-06-01
DOI10.1016/j.pbb.2009.02.013
92期:4页:603-607
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]INDUCED RESPONSES ; SEEKING BEHAVIOR ; COCAINE-SEEKING ; ANIMAL-MODEL ; RATS ; REINSTATEMENT ; STRESS ; USERS ; PAIN ; INACTIVATION
英文摘要

Background: Tetrodotoxin (TTX) is a neurotoxin found in Puffer fish and other marine animals. New clinical studies Suggest that low-dose TTX can safely relieve severe, treatment-resistant cancer pain. The therapeutic potential of TTX in addiction is supported by studies in laboratory animals. The purpose of this double-blind, placebo-controlled study was to assess the effect of a single intramuscular dose of TTX on cue-induced craving and anxiety in abstinent heroin addicts.

Methods: Forty-five abstinent heroin addicts were randomly assigned to three treatment groups: placebo, 5 mu g TTX, or 10 mu g TTX. Participants were exposed to a neutral video or a heroin-related video. Craving. anxiety, blood pressure, and heart rate were measured pre- and post-exposure.

Results: Heroin-related cues increased both craving and anxiety and had no effect on blood pressure and heart rate. A single dose of TTX dose-dependently attenuated the increases in craving and anxiety while having no effect on blood pressure or heart rate.

Conclusion: The results suggest that low-dose TTX is acutely effective in reducing cue-induced increases in heroin craving and associated anxiety. (c) 2009 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000266538800007
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58928
Collection中国药物依赖性研究所
北京大学医学部管理机构_医学部
北京大学第三临床医学院_骨科
北京大学第三临床医学院_总务处
作者单位1.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
2.Natl Inst Drug Abuse, Intramural Res Program, NIH, Baltimore, MD 21224 USA
Recommended Citation
GB/T 7714
Shi, Jie,Liu, Ting-Ting,Wang, Xi,et al. Tetrodotoxin reduces cue-induced drug craving and anxiety in abstinent heroin addicts[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2009,92(4):603-607.
APA Shi, Jie.,Liu, Ting-Ting.,Wang, Xi.,Epstein, David H..,Zhao, Li-Yan.,...&Lu, Lin.(2009).Tetrodotoxin reduces cue-induced drug craving and anxiety in abstinent heroin addicts.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,92(4),603-607.
MLA Shi, Jie,et al."Tetrodotoxin reduces cue-induced drug craving and anxiety in abstinent heroin addicts".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 92.4(2009):603-607.
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