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学科主题: 药物依赖
题名:
Tetrodotoxin reduces cue-induced drug craving and anxiety in abstinent heroin addicts
作者: Shi, Jie1; Liu, Ting-Ting1; Wang, Xi1; Epstein, David H.2; Zhao, Li-Yan1; Zhang, Xiao-Li1; Lu, Lin1
关键词: Drug cues ; Heroin dependence ; Tetrodotoxin ; Craving
刊名: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
发表日期: 2009-06-01
DOI: 10.1016/j.pbb.2009.02.013
卷: 92, 期:4, 页:603-607
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]: INDUCED RESPONSES ; SEEKING BEHAVIOR ; COCAINE-SEEKING ; ANIMAL-MODEL ; RATS ; REINSTATEMENT ; STRESS ; USERS ; PAIN ; INACTIVATION
英文摘要:

Background: Tetrodotoxin (TTX) is a neurotoxin found in Puffer fish and other marine animals. New clinical studies Suggest that low-dose TTX can safely relieve severe, treatment-resistant cancer pain. The therapeutic potential of TTX in addiction is supported by studies in laboratory animals. The purpose of this double-blind, placebo-controlled study was to assess the effect of a single intramuscular dose of TTX on cue-induced craving and anxiety in abstinent heroin addicts.

Methods: Forty-five abstinent heroin addicts were randomly assigned to three treatment groups: placebo, 5 mu g TTX, or 10 mu g TTX. Participants were exposed to a neutral video or a heroin-related video. Craving. anxiety, blood pressure, and heart rate were measured pre- and post-exposure.

Results: Heroin-related cues increased both craving and anxiety and had no effect on blood pressure and heart rate. A single dose of TTX dose-dependently attenuated the increases in craving and anxiety while having no effect on blood pressure or heart rate.

Conclusion: The results suggest that low-dose TTX is acutely effective in reducing cue-induced increases in heroin craving and associated anxiety. (c) 2009 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2007CB512302 ; 2006AA02Z4D1 ; 30611120528
项目资助者: National Basic Research Program of China ; National High Technology Research and Development Program of China ; China-Canada joint Health Research Program
WOS记录号: WOS:000266538800007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58928
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
2.Natl Inst Drug Abuse, Intramural Res Program, NIH, Baltimore, MD 21224 USA

Recommended Citation:
Shi, Jie,Liu, Ting-Ting,Wang, Xi,et al. Tetrodotoxin reduces cue-induced drug craving and anxiety in abstinent heroin addicts[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2009,92(4):603-607.
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