北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 中国药物依赖性研究所  > 期刊论文
学科主题: 药物依赖
题名:
Tetrodotoxin reduces cue-induced drug craving and anxiety in abstinent heroin addicts
作者: Shi, Jie1; Liu, Ting-Ting1; Wang, Xi1; Epstein, David H.2; Zhao, Li-Yan1; Zhang, Xiao-Li1; Lu, Lin1
关键词: Drug cues ; Heroin dependence ; Tetrodotoxin ; Craving
刊名: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
发表日期: 2009-06-01
DOI: 10.1016/j.pbb.2009.02.013
卷: 92, 期:4, 页:603-607
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]: INDUCED RESPONSES ; SEEKING BEHAVIOR ; COCAINE-SEEKING ; ANIMAL-MODEL ; RATS ; REINSTATEMENT ; STRESS ; USERS ; PAIN ; INACTIVATION
英文摘要:

Background: Tetrodotoxin (TTX) is a neurotoxin found in Puffer fish and other marine animals. New clinical studies Suggest that low-dose TTX can safely relieve severe, treatment-resistant cancer pain. The therapeutic potential of TTX in addiction is supported by studies in laboratory animals. The purpose of this double-blind, placebo-controlled study was to assess the effect of a single intramuscular dose of TTX on cue-induced craving and anxiety in abstinent heroin addicts.

Methods: Forty-five abstinent heroin addicts were randomly assigned to three treatment groups: placebo, 5 mu g TTX, or 10 mu g TTX. Participants were exposed to a neutral video or a heroin-related video. Craving. anxiety, blood pressure, and heart rate were measured pre- and post-exposure.

Results: Heroin-related cues increased both craving and anxiety and had no effect on blood pressure and heart rate. A single dose of TTX dose-dependently attenuated the increases in craving and anxiety while having no effect on blood pressure or heart rate.

Conclusion: The results suggest that low-dose TTX is acutely effective in reducing cue-induced increases in heroin craving and associated anxiety. (c) 2009 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2007CB512302 ; 2006AA02Z4D1 ; 30611120528
项目资助者: National Basic Research Program of China ; National High Technology Research and Development Program of China ; China-Canada joint Health Research Program
WOS记录号: WOS:000266538800007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58928
Appears in Collections:中国药物依赖性研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
2.Natl Inst Drug Abuse, Intramural Res Program, NIH, Baltimore, MD 21224 USA

Recommended Citation:
Shi, Jie,Liu, Ting-Ting,Wang, Xi,et al. Tetrodotoxin reduces cue-induced drug craving and anxiety in abstinent heroin addicts[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2009,92(4):603-607.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Shi, Jie]'s Articles
[Liu, Ting-Ting]'s Articles
[Wang, Xi]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Shi, Jie]‘s Articles
[Liu, Ting-Ting]‘s Articles
[Wang, Xi]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace