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学科主题: 临床医学
题名:
A Population-Based Clinical Trial Comparing Endocervical High-Risk HPV Testing Using Hybrid Capture 2 and Cervista From the SHENCCAST II Study
作者: Belinson, Jerome L.1,5; Wu, Ruifang2; Belinson, Suzanne E.1; Qu, Xinfeng3; Yang, Bin4; Du, Hui2; Wu, Ruosong3; Wang, Chun2; Zhang, Lijie2; Zhou, Yanqiu2; Liu, Ying2; Pretorius, Robert G.6
关键词: Hybrid Capture 2 ; Cervista ; Cervical cancer screening ; Human papillomavirus ; HPV
刊名: AMERICAN JOURNAL OF CLINICAL PATHOLOGY
发表日期: 2011-05-01
DOI: 10.1309/AJCPKA6ATAPBZ6JQ
卷: 135, 期:5, 页:790-795
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: GRADE CERVICAL LESIONS ; HUMAN-PAPILLOMAVIRUS ; CANCER ; WOMEN ; PERFORMANCE ; CYTOLOGY ; DETECT ; HR
英文摘要:

Our objective was to directly compare the accuracy of the high-risk human papillomavirus (HPV) assays, Hybrid Capture 2 (hc2; Qiagen, Gaithersburg, MD) and Cervista (Hologic, Bedford, MA), in diagnosing cervical intraepithelial neoplasia (CIN) 3 or worse (cancer).

A population-based, cross-sectional study (The Shenzhen Cervical Cancer Screening Trial II) was conducted in Guangdong Province in China. Three high-risk HP V assays, self and direct cervical sampling and cytology, were studied. Abnormal results on any of 6 study tests (33%) resulted in referral to colposcopy. At colposcopy, every patient had at least 5 cervical biopsy specimens obtained.

For 8,556 women between the ages of 25 and 59 years (mean, 38.9 years), the rate for CIN 3 or worse was 1.6% (141/8,556). The sensitivity (confidence interval) values for CIN 3 or worse were 97.9% (94.0%-99.6%) and 95.1% (90.0%-98.0%) for hc2 and Cervista, respectively (P > .05). The specificity (confidence interval) values were 87.8% (87.1%-88.5%) and 90.3% (89.6%-90.9%), respectively P < .05).

Differences in accuracy in diagnosing CIN 3 or worse with the hc2 and Cervista tests are minor and result from the decisions made in selecting the cut points.

语种: 英语
项目资助者: Preventive Oncology International, Cleveland Heights, OH ; Hologic, Bedford, MA ; Shenzhen Female Doctors Association, Shenzhen, Peoples Republic of China
WOS记录号: WOS:000289743400019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58930
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Prevent Oncol Int, Cleveland Hts, OH USA
2.Peking Univ, Shenzhen Hosp, Shenzhen, Peoples R China
3.Royal Ladies Clin, Shenzhen, Peoples R China
4.Cleveland Clin, Dept Anat Pathol, Cleveland, OH 44106 USA
5.Cleveland Clin, Dept Obstet & Gynecol, Cleveland, OH 44106 USA
6.Kaiser Permanente, Dept Obstet & Gynecol, Fontana, CA USA

Recommended Citation:
Belinson, Jerome L.,Wu, Ruifang,Belinson, Suzanne E.,et al. A Population-Based Clinical Trial Comparing Endocervical High-Risk HPV Testing Using Hybrid Capture 2 and Cervista From the SHENCCAST II Study[J]. AMERICAN JOURNAL OF CLINICAL PATHOLOGY,2011,135(5):790-795.
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