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Syntheses of some 17-heterocyclic substituted androstene derivatives as inhibitors of human 17 alpha-hydroxylase/C-17,C-20-layse(P450(17 alpha))
Ru, CJ; Lei, XP; Ling, YZ; Zhang, LH; Hundratta, V; Brodie, AMH
关键词cytochrome P450(17 alpha) benign prostatic hypertrophy prostatic cancer inhibitors
刊名CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
2001-06-01
22期:6页:931-935
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]STEROIDAL INHIBITORS ; POTENTIAL AGENTS ; PROSTATE-CANCER ; P450(17-ALPHA) ; 17-ALPHA-HYDROXYLASE-C-17,C-20-LYASE
英文摘要

17-(3 ′ -Pyrazolyl) and 17-(5 ′ -isoxazolyl)androsta-4 , 16-dien-3-one have been found to be potent inhibitors for human testicular microsomal 17 alpha -hydroxylase/C-17,C-20-layse, which showed potential usage in the treatment of benign prostatic hypertrophy(BPH) and prostatic cancer. In order to further investigate their structure-activity relationship, some substituents were introduced at the 5 ′ -position of pyrazole and 3 ′ -position of isoxazole, and eleven derivatives were obtained. The structures of the compounds were confirmed by IR, H-1 NMR, elemental analysis or MS measurements. Their pharmacological activities are under investigation.

语种中文
WOS记录号WOS:000169605000016
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58934
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Univ Maryland, Sch Med, Dept Pharmacol & Expt Therapeut, Baltimore, MD 21201 USA
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GB/T 7714
Ru, CJ,Lei, XP,Ling, YZ,et al. Syntheses of some 17-heterocyclic substituted androstene derivatives as inhibitors of human 17 alpha-hydroxylase/C-17,C-20-layse(P450(17 alpha))[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2001,22(6):931-935.
APA Ru, CJ,Lei, XP,Ling, YZ,Zhang, LH,Hundratta, V,&Brodie, AMH.(2001).Syntheses of some 17-heterocyclic substituted androstene derivatives as inhibitors of human 17 alpha-hydroxylase/C-17,C-20-layse(P450(17 alpha)).CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,22(6),931-935.
MLA Ru, CJ,et al."Syntheses of some 17-heterocyclic substituted androstene derivatives as inhibitors of human 17 alpha-hydroxylase/C-17,C-20-layse(P450(17 alpha))".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 22.6(2001):931-935.
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