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学科主题: 药学
题名:
Syntheses of some 17-heterocyclic substituted androstene derivatives as inhibitors of human 17 alpha-hydroxylase/C-17,C-20-layse(P450(17 alpha))
作者: Ru, CJ; Lei, XP; Ling, YZ; Zhang, LH; Hundratta, V; Brodie, AMH
关键词: cytochrome P450(17 alpha) ; benign prostatic hypertrophy ; prostatic cancer ; inhibitors
刊名: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
发表日期: 2001-06-01
卷: 22, 期:6, 页:931-935
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: STEROIDAL INHIBITORS ; POTENTIAL AGENTS ; PROSTATE-CANCER ; P450(17-ALPHA) ; 17-ALPHA-HYDROXYLASE-C-17,C-20-LYASE
英文摘要:

17-(3 ′ -Pyrazolyl) and 17-(5 ′ -isoxazolyl)androsta-4 , 16-dien-3-one have been found to be potent inhibitors for human testicular microsomal 17 alpha -hydroxylase/C-17,C-20-layse, which showed potential usage in the treatment of benign prostatic hypertrophy(BPH) and prostatic cancer. In order to further investigate their structure-activity relationship, some substituents were introduced at the 5 ′ -position of pyrazole and 3 ′ -position of isoxazole, and eleven derivatives were obtained. The structures of the compounds were confirmed by IR, H-1 NMR, elemental analysis or MS measurements. Their pharmacological activities are under investigation.

语种: 中文
WOS记录号: WOS:000169605000016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58934
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Univ Maryland, Sch Med, Dept Pharmacol & Expt Therapeut, Baltimore, MD 21201 USA

Recommended Citation:
Ru, CJ,Lei, XP,Ling, YZ,et al. Syntheses of some 17-heterocyclic substituted androstene derivatives as inhibitors of human 17 alpha-hydroxylase/C-17,C-20-layse(P450(17 alpha))[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2001,22(6):931-935.
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