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学科主题: 临床医学
题名:
Randomised controlled trial: sequential vs. standard triple therapy for Helicobacter pylori infection in Chinese children-a multicentre, open-labelled study
作者: Huang, J.1; Zhou, L.2; Geng, L.1; Yang, M.1; Xu, X. -W.3; Ding, Z. -L.3; Mao, M.4; Wang, Z. -L.4; Li, Z. -L.2; Li, D. -Y.5; Gong, S. -T.1
刊名: ALIMENTARY PHARMACOLOGY & THERAPEUTICS
发表日期: 2013-11-01
DOI: 10.1111/apt.12516
卷: 38, 期:10, 页:1230-1235
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology ; Pharmacology & Pharmacy
研究领域[WOS]: Gastroenterology & Hepatology ; Pharmacology & Pharmacy
关键词[WOS]: ANTIBIOTIC-RESISTANCE ; DOUBLE-BLIND ; ERADICATION ; CLARITHROMYCIN ; METAANALYSIS ; GUIDELINES ; STRAINS ; PERIOD ; 7-DAY ; NAIVE
英文摘要:

BackgroundStudies have showed that 10-day sequential treatment regimen achieved higher Helicobacter pylori eradication rate than standard triple therapies.

AimTo compare a 10-day sequential therapy and standard triple therapy in Chinese children with H. pylori infection.

MethodsA prospective, multicentre, open-label, randomised controlled trial was conducted in four tertiary medical centres in China. Children with H. pylori gastritis were randomly assigned to a 10-day sequential therapy consisting of omeprazole and amoxicillin for 5days followed by omeprazole, clarithromycin and metronidazole for the remaining 5days, or 7-day or 10-day standard triple therapy comprising of omeprazole, amoxicillin and clarithromycin. H. pylori eradication was assessed by H. pylori stool antigen test.

ResultsA total of 360 patients were included. The eradication rate achieved with the 10-day sequential therapy was significantly higher than either the 7-day or 10-day standard triple treatment, either by the intention-to-treat analysis (81.4% vs. 61.9% or 67.7%, P<0.05) or per-protocol analysis (89.7% vs. 70.8% or 77.8%, P<0.05).

ConclusionsThe 10-day sequential regimen was significantly more effective than standard 7-day or 10-day triple regimens in eradicating H. pylori infection in Chinese children.

语种: 英语
所属项目编号: 2007BAI04B02
项目资助者: Key Projects of the National Science &amp ; Technology Pillar Program of China
WOS记录号: WOS:000325977700007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58935
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Beijing 100871, Peoples R China
2.Beijing Childrens Hosp, Beijing, Peoples R China
3.Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Guangzhou, Guangdong, Peoples R China
4.Sichuan Univ, West China Hosp 2, Chengdu 610064, Peoples R China
5.Univ Missouri, Sch Med, Div Gastroenterol, Childrens Mercy Hosp, Kansas City, MO 64108 USA

Recommended Citation:
Huang, J.,Zhou, L.,Geng, L.,et al. Randomised controlled trial: sequential vs. standard triple therapy for Helicobacter pylori infection in Chinese children-a multicentre, open-labelled study[J]. ALIMENTARY PHARMACOLOGY &amp; THERAPEUTICS,2013,38(10):1230-1235.
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