IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Randomised controlled trial: sequential vs. standard triple therapy for Helicobacter pylori infection in Chinese children-a multicentre, open-labelled study
Huang, J.1; Zhou, L.2; Geng, L.1; Yang, M.1; Xu, X. -W.3; Ding, Z. -L.3; Mao, M.4; Wang, Z. -L.4; Li, Z. -L.2; Li, D. -Y.5; Gong, S. -T.1
刊名ALIMENTARY PHARMACOLOGY & THERAPEUTICS
2013-11-01
DOI10.1111/apt.12516
38期:10页:1230-1235
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Pharmacology & Pharmacy
研究领域[WOS]Gastroenterology & Hepatology ; Pharmacology & Pharmacy
关键词[WOS]ANTIBIOTIC-RESISTANCE ; DOUBLE-BLIND ; ERADICATION ; CLARITHROMYCIN ; METAANALYSIS ; GUIDELINES ; STRAINS ; PERIOD ; 7-DAY ; NAIVE
英文摘要

BackgroundStudies have showed that 10-day sequential treatment regimen achieved higher Helicobacter pylori eradication rate than standard triple therapies.

AimTo compare a 10-day sequential therapy and standard triple therapy in Chinese children with H. pylori infection.

MethodsA prospective, multicentre, open-label, randomised controlled trial was conducted in four tertiary medical centres in China. Children with H. pylori gastritis were randomly assigned to a 10-day sequential therapy consisting of omeprazole and amoxicillin for 5days followed by omeprazole, clarithromycin and metronidazole for the remaining 5days, or 7-day or 10-day standard triple therapy comprising of omeprazole, amoxicillin and clarithromycin. H. pylori eradication was assessed by H. pylori stool antigen test.

ResultsA total of 360 patients were included. The eradication rate achieved with the 10-day sequential therapy was significantly higher than either the 7-day or 10-day standard triple treatment, either by the intention-to-treat analysis (81.4% vs. 61.9% or 67.7%, P<0.05) or per-protocol analysis (89.7% vs. 70.8% or 77.8%, P<0.05).

ConclusionsThe 10-day sequential regimen was significantly more effective than standard 7-day or 10-day triple regimens in eradicating H. pylori infection in Chinese children.

语种英语
WOS记录号WOS:000325977700007
项目编号2007BAI04B02
资助机构Key Projects of the National Science &amp ; Technology Pillar Program of China
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58935
专题北京大学第三临床医学院
作者单位1.Peking Univ, Hosp 3, Beijing 100871, Peoples R China
2.Beijing Childrens Hosp, Beijing, Peoples R China
3.Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Guangzhou, Guangdong, Peoples R China
4.Sichuan Univ, West China Hosp 2, Chengdu 610064, Peoples R China
5.Univ Missouri, Sch Med, Div Gastroenterol, Childrens Mercy Hosp, Kansas City, MO 64108 USA
推荐引用方式
GB/T 7714
Huang, J.,Zhou, L.,Geng, L.,et al. Randomised controlled trial: sequential vs. standard triple therapy for Helicobacter pylori infection in Chinese children-a multicentre, open-labelled study[J]. ALIMENTARY PHARMACOLOGY &amp; THERAPEUTICS,2013,38(10):1230-1235.
APA Huang, J..,Zhou, L..,Geng, L..,Yang, M..,Xu, X. -W..,...&Gong, S. -T..(2013).Randomised controlled trial: sequential vs. standard triple therapy for Helicobacter pylori infection in Chinese children-a multicentre, open-labelled study.ALIMENTARY PHARMACOLOGY & THERAPEUTICS,38(10),1230-1235.
MLA Huang, J.,et al."Randomised controlled trial: sequential vs. standard triple therapy for Helicobacter pylori infection in Chinese children-a multicentre, open-labelled study".ALIMENTARY PHARMACOLOGY & THERAPEUTICS 38.10(2013):1230-1235.
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