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学科主题: 临床医学
题名:
Heart rate variability predicts mortality in peritoneal dialysis patients
作者: Pei, Juan1,2; Tang, Wen2; Li, Li-Xian3; Su, Chun-Yan2; Wang, Tao2
关键词: Autonomic nervous system ; chronic kidney disease ; heart rate variability ; mortality ; peritoneal dialysis
刊名: RENAL FAILURE
发表日期: 2015
DOI: 10.3109/0886022X.2015.1061729
卷: 37, 期:7, 页:1132-1137
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: STAGE RENAL-DISEASE ; CHRONIC KIDNEY-DISEASE ; MYOCARDIAL-INFARCTION ; CHRONIC-HEMODIALYSIS ; PROGNOSTIC VALUE ; RISK ; BODY ; IMPACT
英文摘要:

Background: The predictive value of heart rate variability (HRV) in peritoneal dialysis (PD) has never been tested. Methods: In this study, the associations between HRV measures and the mortality in 81 PD patients were analyzed. HRV was measured by using 5-min recordings of a stationary system by a standardized method. Both time domain and frequency domain parameters were analyzed. Results: During a follow-up period of 43.78 +/- 14.77 months, 25 patients died, four patients were transferred to hemodialysis. Of the 81 patients, the time domain parameters, such as the standard deviation of differences between adjacent normal sinus to normal sinus (NN) intervals (SDSD) and the square root of the mean of the squared differences between adjacent normal NN intervals (RMSSD), were higher; the frequency domain parameters, such as the ratio of low-frequency power to high-frequency power (LF/HF) and the normalized LF, were lower, and the normalized HF was higher in the non-survived group as compared with the survived group. A Cox proportional hazards model analysis revealed that, of the HRV measures, decrease of the normalized LF, LF/HF and increase of rMSSD, SDSD, normalized HF had significant predictive value for mortality. After adjustment for other univariate predictors including age, urine volume, renal Kt/V, high-sensitivity C-reactive protein (hs-CRP), the predictive value of decreased LF/HF remained significant. Kaplan-Meier survival analysis showed mortality rate was much higher in patients with a low LF/HF (median value of 1.56). Conclusion: The decreases of LF/HF which reflects impaired sympathetic nerve regulation is an independent predictor of mortality in PD patients.

语种: 英语
WOS记录号: WOS:000361339400011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58941
Appears in Collections:北京大学第三临床医学院_肾内科_期刊论文

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作者单位: 1.Xiamen Univ, Div Nephrol, Hosp 1, Xiamen, Peoples R China
2.Peking Univ, Div Nephrol, Hosp 3, Beijing 100191, Peoples R China
3.Guangdong Prov Hosp Tradit Chinese Med, Div Nephrol, Guangzhou, Guangdong, Peoples R China

Recommended Citation:
Pei, Juan,Tang, Wen,Li, Li-Xian,et al. Heart rate variability predicts mortality in peritoneal dialysis patients[J]. RENAL FAILURE,2015,37(7):1132-1137.
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