北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 药剂科  > 期刊论文
学科主题: 临床医学
题名:
Effects of the CYP3A4*1B Genetic Polymorphism on the Pharmacokinetics of Tacrolimus in Adult Renal Transplant Recipients: A Meta-Analysis
作者: Shi, Wei-Long; Tang, Hui-Lin; Zhai, Suo-Di
刊名: PLOS ONE
发表日期: 2015-06-03
DOI: 10.1371/journal.pone.0127995
卷: 10, 期:6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: SOLID-ORGAN TRANSPLANTATION ; ACUTE REJECTION RATES ; CYTOCHROME-P450 3A ; CALCINEURIN INHIBITORS ; DOSE REQUIREMENTS ; CYP3A5 ; LIVER ; PHARMACOGENETICS ; CYCLOSPORINE ; DISPOSITION
英文摘要:

Background and Objective

The association between the CYP3A4*1B single nucleotide polymorphism (SNP) and tacrolimus pharmacokinetics in different studies is controversial. Therefore, a meta-analysis was employed to evaluate the correlation between the CYP3A4*1B genetic polymorphism and tacrolimus pharmacokinetics at different post-transplantation times in adult renal transplant recipients.

Methods

Studies evaluating the CYP3A4*1B genetic polymorphism and tacrolimus pharmacokinetics were retrieved through a systematical search of Embase, PubMed, the Cochrane Library, ClinicalTrials.gov and three Chinese literature databases (up to Sept. 2014). The pharmacokinetic parameters (weight-adjusted tacrolimus daily dose and tacrolimus trough concentration/weight-adjusted tacrolimus daily dose ratio) were extracted, and the meta-analysis was performed using Stata 12.1.

Results

Seven studies (involving 1182 adult renal transplant recipients) were included in this meta-analysis. For the weight-adjusted tacrolimus daily dose, in all included renal transplant recipients (European & Indian populations), CYP3A4*1/*1 recipients required a significantly lower weight-adjusted tacrolimus daily dose than did CYP3A4* 1B carriers at 7 days (WMD -0.048; 95% CI -0.083 similar to -0.014), 6 months (WMD -0.058; 95% CI -0.081 similar to -0.036) and 12 months (WMD -0.061; 95% CI -0.096 similar to -0.027) post-transplantation. In light of the heterogeneity, the analysis was repeated after removing the only study in an Indian population, and CYP3A4*1/*1 European recipients (mostly Caucasian) required a lower weight-adjusted tacrolimus daily dose within the first year post-transplantation. The tacrolimus trough concentration/weight-adjusted tacrolimus daily dose ratio (C-0/Dose ratio) was significantly higher in CYP3A4*1/*1 recipients than in CYP3A4*1B carriers at 6 months (WMD 52.588; 95% CI 22.387 similar to 82.789) and 12 months (WMD 62.219; 95% CI 14.218 similar to 110.221) post-transplantation. When the only study in an Indian population was removed to examine European recipients (mostly Caucasian), the significant difference persisted at 1 month, 6 months and 12 months post-transplantation.

Conclusion

Based on our meta-analysis, the CYP3A4*1B genetic polymorphism affects tacrolimus dose requirements and tacrolimus trough concentration/weight-adjusted tacrolimus daily dose ratio within the first year post-transplantation in adult renal transplant recipients, especially in European recipients (mostly Caucasian).

语种: 英语
WOS记录号: WOS:000355700700084
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58949
Appears in Collections:北京大学第三临床医学院_药剂科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Hosp 3, Dept Pharm, Beijing 100871, Peoples R China

Recommended Citation:
Shi, Wei-Long,Tang, Hui-Lin,Zhai, Suo-Di. Effects of the CYP3A4*1B Genetic Polymorphism on the Pharmacokinetics of Tacrolimus in Adult Renal Transplant Recipients: A Meta-Analysis[J]. PLOS ONE,2015,10(6).
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Shi, Wei-Long]'s Articles
[Tang, Hui-Lin]'s Articles
[Zhai, Suo-Di]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Shi, Wei-Long]‘s Articles
[Tang, Hui-Lin]‘s Articles
[Zhai, Suo-Di]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace