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学科主题: 临床医学
题名:
Association of suppressor of cytokine signalling 3 polymorphisms with insulin resistance in patients with chronic hepatitis C
作者: Zheng, Y-Y1; Wang, L-F1; Fan, X-H1; Wu, C-H1; Huo, N.1; Lu, H-Y1; Xu, X-Y1; Wei, L.2
关键词: Hepatitis C ; Insulin resistance ; Suppressor of cytokine signalling 3
刊名: JOURNAL OF VIRAL HEPATITIS
发表日期: 2013-04-01
DOI: 10.1111/j.1365-2893.2012.01644.x
卷: 20, 期:4, 页:273-280
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology ; Infectious Diseases ; Virology
研究领域[WOS]: Gastroenterology & Hepatology ; Infectious Diseases ; Virology
关键词[WOS]: ANTIVIRAL THERAPY ; RECEPTOR SUBSTRATE-1 ; ELEVATED EXPRESSION ; METABOLIC SYNDROME ; SOCS3 EXPRESSION ; VIRUS-INFECTION ; CORE PROTEIN ; HCV ; GENOTYPE-1 ; LIVER
英文摘要:

Suppressor of cytokine signalling 3 is thought to be associated with insulin resistance in patients with chronic hepatitis C. We evaluated the role of suppressor of cytokine signalling 3 polymorphisms in determining insulin resistance in patients with chronic hepatitis C. Two hundred and ninety untreated hepatitis C virus-infected patients without diabetes and cirrhosis were genotyped for the SNPs rs4969168, rs4969170 and rs12952093 of suppressor of cytokine signalling 3 using the TaqMan Genotyping Assay. We found that the rs4969170 AA genotype and rs4969170 A allele frequency were significantly more common in the insulin-resistant group than the non-insulin-resistant group (89.5% vs 76.1%, OR=2.693, 95% CI: 1.221-5.939, P=0.012 and 94.8% vs 88.0%, OR=2.463, 95% CI: 1.1515.271, P=0.017, respectively). Haplotype G-C was likely associated with non-insulin resistance (adjusted P=0.011). Multiple logistic regression analysis indicates that the independent risk factors for insulin resistance are the SNP rs4969170 AA genotype (OR=3.005, 95% CI: 1.1947.560, P=0.019), HCV genotype 1 (OR=2.524, 95% CI: 1.0995.794, P= 0.029) and BMI (OR=0.514, 95% CI: 0.2650.999, P=0.05).

语种: 英语
所属项目编号: 2008ZX10002-013 ; 30771906 ; 20090001110081
项目资助者: National Major Project for Infectious Diseases Control ; National Natural Science Foundation of China ; Ph.D. Programs Foundation of Ministry of Education of China
WOS记录号: WOS:000316330000028
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58955
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Infect Dis, Beijing 100034, Peoples R China
2.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing 100044, Peoples R China

Recommended Citation:
Zheng, Y-Y,Wang, L-F,Fan, X-H,et al. Association of suppressor of cytokine signalling 3 polymorphisms with insulin resistance in patients with chronic hepatitis C[J]. JOURNAL OF VIRAL HEPATITIS,2013,20(4):273-280.
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