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学科主题: 临床医学
题名:
PIK3CA mutations in endometrial carcinomas in Chinese women: phosphatidylinositol 3 ′-kinase pathway alterations might be associated with favorable prognosis
作者: Dong, Ying2; Yang, Xi1; Wong, Oscar3; Zhang, Xiaoming2; Liang, Ying2; Zhang, Ying2; Wong, Wei2; Nong, Lin2; Liao, Qinping1; Li, Ting2
关键词: PIK3CA mutations ; PI3K-AKT pathway alteration ; Prognosis ; Endometrial carcinomas ; Chinese women
刊名: HUMAN PATHOLOGY
发表日期: 2012-08-01
DOI: 10.1016/j.humpath.2011.08.021
卷: 43, 期:8, 页:1197-1205
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: MOLECULAR ALTERATIONS ; RECEPTOR EXPRESSION ; HIGH-FREQUENCY ; HUMAN CANCER ; PTEN ; AKT ; OVEREXPRESSION ; AMPLIFICATION ; ACTIVATION ; PI3K-AKT
英文摘要:

The aim of this study was to determine the clinicopathological impact of PIK3CA mutations and phosphatidylinositol 3′-kinase pathway alterations in endometrial cancers in Chinese women. The PIK3CA mutation status was analyzed by sequencing in 94 tumors. The status of phosphatase and tensin homolog, p-(Ser/Thr)AKT, human epidermal growth factor receptor 2, p53, and estrogen and progesterone receptor was assessed in 102 tumors using immunohistochemistry. Biomarker status was correlated with clinicopathologic variables and with patient survival. We found that 28 mutations occurred in the helical domain encoded by exon 9 of PIK3CA and 16 occurred in the kinase domain (exon 20). Mutations of both exons were more common in low-grade than in high-grade endometrioid carcinomas, and the correlation between exon 9 mutation and lower grade was statistically significant (P = .045). In univariate analysis, phosphatidylinositol 3′-kinase pathway activation (defined as PIK3CA mutation and/or phosphatase and tensin homolog loss) was associated with a favorable prognosis (P = .034) and showed an increased predictive power when combined with expression of p-AKT, the phosphatidylinositol 3′-kinase pathway downstream effector (P = .022). In multivariate analysis, phosphatidylinositol 3′-kinase pathway activation was not an independent predictor of disease-free survival (P = .091). Interestingly, in the estrogen receptor-negative subgroup, the phosphatidylinositol 3′-kinase pathway alteration was significantly related to prolonged patient survival (P = .048), whereas this association was not present in the estrogen receptor-positive subgroup (P > .05). Our findings suggest that phosphatidylinositol 3′-kinase pathway alteration might have a favorable prognostic impact on endometrial cancers in Chinese women. Furthermore, the function of the phosphatidylinositol 3′-kinase pathway might be affected by estrogen receptor status. (C) 2012 Elsevier Inc. All rights reserved.

语种: 英语
项目资助者: Peking University First Hospital Research Fund (Beijing, P.R. China)
WOS记录号: WOS:000306979800006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58961
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, First Hosp, Dept Gynecol & Obstet, Beijing 100034, Peoples R China
2.Peking Univ, First Hosp, Dept Pathol, Beijing 100034, Peoples R China
3.Univ Hong Kong, Queen Mary Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Dong, Ying,Yang, Xi,Wong, Oscar,et al. PIK3CA mutations in endometrial carcinomas in Chinese women: phosphatidylinositol 3 ′-kinase pathway alterations might be associated with favorable prognosis[J]. HUMAN PATHOLOGY,2012,43(8):1197-1205.
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