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PIK3CA mutations in endometrial carcinomas in Chinese women: phosphatidylinositol 3 ′-kinase pathway alterations might be associated with favorable prognosis
Dong, Ying2; Yang, Xi1; Wong, Oscar3; Zhang, Xiaoming2; Liang, Ying2; Zhang, Ying2; Wong, Wei2; Nong, Lin2; Liao, Qinping1; Li, Ting2
关键词PIK3CA mutations PI3K-AKT pathway alteration Prognosis Endometrial carcinomas Chinese women
刊名HUMAN PATHOLOGY
2012-08-01
DOI10.1016/j.humpath.2011.08.021
43期:8页:1197-1205
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pathology
研究领域[WOS]Pathology
关键词[WOS]MOLECULAR ALTERATIONS ; RECEPTOR EXPRESSION ; HIGH-FREQUENCY ; HUMAN CANCER ; PTEN ; AKT ; OVEREXPRESSION ; AMPLIFICATION ; ACTIVATION ; PI3K-AKT
英文摘要

The aim of this study was to determine the clinicopathological impact of PIK3CA mutations and phosphatidylinositol 3′-kinase pathway alterations in endometrial cancers in Chinese women. The PIK3CA mutation status was analyzed by sequencing in 94 tumors. The status of phosphatase and tensin homolog, p-(Ser/Thr)AKT, human epidermal growth factor receptor 2, p53, and estrogen and progesterone receptor was assessed in 102 tumors using immunohistochemistry. Biomarker status was correlated with clinicopathologic variables and with patient survival. We found that 28 mutations occurred in the helical domain encoded by exon 9 of PIK3CA and 16 occurred in the kinase domain (exon 20). Mutations of both exons were more common in low-grade than in high-grade endometrioid carcinomas, and the correlation between exon 9 mutation and lower grade was statistically significant (P = .045). In univariate analysis, phosphatidylinositol 3′-kinase pathway activation (defined as PIK3CA mutation and/or phosphatase and tensin homolog loss) was associated with a favorable prognosis (P = .034) and showed an increased predictive power when combined with expression of p-AKT, the phosphatidylinositol 3′-kinase pathway downstream effector (P = .022). In multivariate analysis, phosphatidylinositol 3′-kinase pathway activation was not an independent predictor of disease-free survival (P = .091). Interestingly, in the estrogen receptor-negative subgroup, the phosphatidylinositol 3′-kinase pathway alteration was significantly related to prolonged patient survival (P = .048), whereas this association was not present in the estrogen receptor-positive subgroup (P > .05). Our findings suggest that phosphatidylinositol 3′-kinase pathway alteration might have a favorable prognostic impact on endometrial cancers in Chinese women. Furthermore, the function of the phosphatidylinositol 3′-kinase pathway might be affected by estrogen receptor status. (C) 2012 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000306979800006
资助机构Peking University First Hospital Research Fund (Beijing, P.R. China)
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58961
专题北京大学第一临床医学院
北京大学第一临床医学院_病理科
作者单位1.Peking Univ, First Hosp, Dept Gynecol & Obstet, Beijing 100034, Peoples R China
2.Peking Univ, First Hosp, Dept Pathol, Beijing 100034, Peoples R China
3.Univ Hong Kong, Queen Mary Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714
Dong, Ying,Yang, Xi,Wong, Oscar,et al. PIK3CA mutations in endometrial carcinomas in Chinese women: phosphatidylinositol 3 ′-kinase pathway alterations might be associated with favorable prognosis[J]. HUMAN PATHOLOGY,2012,43(8):1197-1205.
APA Dong, Ying.,Yang, Xi.,Wong, Oscar.,Zhang, Xiaoming.,Liang, Ying.,...&Li, Ting.(2012).PIK3CA mutations in endometrial carcinomas in Chinese women: phosphatidylinositol 3 ′-kinase pathway alterations might be associated with favorable prognosis.HUMAN PATHOLOGY,43(8),1197-1205.
MLA Dong, Ying,et al."PIK3CA mutations in endometrial carcinomas in Chinese women: phosphatidylinositol 3 ′-kinase pathway alterations might be associated with favorable prognosis".HUMAN PATHOLOGY 43.8(2012):1197-1205.
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