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学科主题: 精神卫生
题名:
Impaired prepulse inhibition of acoustic startle in Chinese patients with first-episode, medication-naive schizophrenia
作者: Wang Zhi-ren1; Tan Yun-long2; Yang Fu-de2; Zhang Wu-fang1; Zou Yi-zhuang2; Tan Shu-ping2; Song Chong-sheng2; Li Ying-li2; Zhang Wei-hua1; Zhou Dong-feng1
关键词: acoustic startle ; prepulse inhibition ; schizophrenia
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2013-02-05
DOI: 10.3760/cma.j.issn.0366-6999.20122077
卷: 126, 期:3, 页:526-531
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: INFORMATION-PROCESSING DEFICITS ; SENSORIMOTOR GATING DEFICITS ; ATYPICAL ANTIPSYCHOTICS ; PERSONALITY-DISORDER ; JAPANESE PATIENTS ; REFLEX ; HABITUATION ; HALOPERIDOL ; ASSOCIATION ; MODULATION
英文摘要:

Background Patients with schizophrenia have prominent abnormality in information processing that can be observed by measures of prepulse inhibition (PPI) of acoustic startle reflex and PPI deficits have been considered as a candidate endophenotypic marker of schizophrenia. However, there has been little information on PPI and related measures in Chinese patients with schizophrenia. The research was to explore the deficits of acoustic startle reflex that might exist in Chinese patients with schizophrenia.

Methods Startle response to acoustic stimuli, habituation, and PPI were examined in 31 Chinese patients with first-episode, medication-naive schizophrenia and 30 age- and sex- matched healthy Chinese controls. At the same day of startle testing, psychopathological symptoms of the patients were assessed with the Positive and Negative Syndrome Scale (PANSS).

Results Compared with healthy controls, patients exhibited the significant reduction in startle response and PPI deficits at 60 milliseconds (ms) intervals (PPI60, P < 0.05) but not at 30 or 120 ms intervals. Furthermore, there was a relatively strong correlation between PPI60 (P < 0.05) and scores of positive scale of PANSS in patients with schizophrenia.

Conclusion Our findings confirmed impaired PPI in Chinese patients with schizophrenia and suggested that a relationship between sensorimotor gating deficits and clinical symptoms of patients with schizophrenia might exist.

语种: 英语
所属项目编号: 2007BC512307 ; 2009-3148 ; 81000579 ; D0906001040191
项目资助者: National Basic Research Program of China (973 Program) ; Capital Medical Development Fund ; National Natural Science Foundation of China ; Beijing Municipal Science &amp ; Technology Commission
WOS记录号: WOS:000319632900024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58964
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Key Lab Mental Hlth, Minist Hlth, Beijing 100191, Peoples R China
2.Beijing Hui Long Guan Hosp, Beijing 100096, Peoples R China

Recommended Citation:
Wang Zhi-ren,Tan Yun-long,Yang Fu-de,et al. Impaired prepulse inhibition of acoustic startle in Chinese patients with first-episode, medication-naive schizophrenia[J]. CHINESE MEDICAL JOURNAL,2013,126(3):526-531.
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