|Impaired prepulse inhibition of acoustic startle in Chinese patients with first-episode, medication-naive schizophrenia|
|Wang Zhi-ren1; Tan Yun-long2; Yang Fu-de2; Zhang Wu-fang1; Zou Yi-zhuang2; Tan Shu-ping2; Song Chong-sheng2; Li Ying-li2; Zhang Wei-hua1; Zhou Dong-feng1|
|关键词||acoustic startle prepulse inhibition schizophrenia|
|刊名||CHINESE MEDICAL JOURNAL|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, General & Internal|
|研究领域[WOS]||General & Internal Medicine|
|关键词[WOS]||INFORMATION-PROCESSING DEFICITS ; SENSORIMOTOR GATING DEFICITS ; ATYPICAL ANTIPSYCHOTICS ; PERSONALITY-DISORDER ; JAPANESE PATIENTS ; REFLEX ; HABITUATION ; HALOPERIDOL ; ASSOCIATION ; MODULATION|
Background Patients with schizophrenia have prominent abnormality in information processing that can be observed by measures of prepulse inhibition (PPI) of acoustic startle reflex and PPI deficits have been considered as a candidate endophenotypic marker of schizophrenia. However, there has been little information on PPI and related measures in Chinese patients with schizophrenia. The research was to explore the deficits of acoustic startle reflex that might exist in Chinese patients with schizophrenia.
Methods Startle response to acoustic stimuli, habituation, and PPI were examined in 31 Chinese patients with first-episode, medication-naive schizophrenia and 30 age- and sex- matched healthy Chinese controls. At the same day of startle testing, psychopathological symptoms of the patients were assessed with the Positive and Negative Syndrome Scale (PANSS).
Results Compared with healthy controls, patients exhibited the significant reduction in startle response and PPI deficits at 60 milliseconds (ms) intervals (PPI60, P < 0.05) but not at 30 or 120 ms intervals. Furthermore, there was a relatively strong correlation between PPI60 (P < 0.05) and scores of positive scale of PANSS in patients with schizophrenia.
Conclusion Our findings confirmed impaired PPI in Chinese patients with schizophrenia and suggested that a relationship between sensorimotor gating deficits and clinical symptoms of patients with schizophrenia might exist.
|项目编号||2007BC512307 ; 2009-3148 ; 81000579 ; D0906001040191|
|资助机构||National Basic Research Program of China (973 Program) ; Capital Medical Development Fund ; National Natural Science Foundation of China ; Beijing Municipal Science & ; Technology Commission|
|作者单位||1.Peking Univ, Inst Mental Hlth, Key Lab Mental Hlth, Minist Hlth, Beijing 100191, Peoples R China|
2.Beijing Hui Long Guan Hosp, Beijing 100096, Peoples R China
|Wang Zhi-ren,Tan Yun-long,Yang Fu-de,et al. Impaired prepulse inhibition of acoustic startle in Chinese patients with first-episode, medication-naive schizophrenia[J]. CHINESE MEDICAL JOURNAL,2013,126(3):526-531.|
|APA||Wang Zhi-ren.,Tan Yun-long.,Yang Fu-de.,Zhang Wu-fang.,Zou Yi-zhuang.,...&Zhou Dong-feng.(2013).Impaired prepulse inhibition of acoustic startle in Chinese patients with first-episode, medication-naive schizophrenia.CHINESE MEDICAL JOURNAL,126(3),526-531.|
|MLA||Wang Zhi-ren,et al."Impaired prepulse inhibition of acoustic startle in Chinese patients with first-episode, medication-naive schizophrenia".CHINESE MEDICAL JOURNAL 126.3(2013):526-531.|