IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Breast MRI After Conservation Therapy: Usual Findings in Routine Follow-Up Examinations
Li, Jie1,2; Dershaw, D. David1; Lee, Carol F.1; Joo, Sandra1; Morris, Elizabeth A.1
关键词breast breast cancer breast conservation breast imaging breast MRI
刊名AMERICAN JOURNAL OF ROENTGENOLOGY
2010-09-01
DOI10.2214/AJR.10.4305
195期:3页:799-807
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]RADIATION-THERAPY ; TUMOR RECURRENCE ; CARCINOMA ; DIFFERENTIATION ; LUMPECTOMY ; SURGERY
英文摘要

OBJECTIVE. The objective of our study was to define the usual alterations in the ipsilateral and contralateral breast on MRI of women who have undergone surgery and radiation for the treatment of primary breast cancer.

MATERIALS AND METHODS. Database searches identified 744 breast MR examinations of 248 women with newly diagnosed primary breast cancer who had undergone standard breast conservation therapy (BCT) and who had undergone MRI before radiotherapy and at least twice after BCT; these MR examinations were reviewed retrospectively. In each MR study, both breasts were evaluated for background enhancement and cystic alteration. In the treated breast, edema, skin thickening, seroma, and enhancement at the lumpectomy site were assessed.

RESULTS. Background enhancement and cystic alteration decreased bilaterally on MRI after completion of surgery and radiation. Edema, skin thickening, seroma, and enhancement at the lumpectomy site progressively decreased over time. These changes never resolved in some women, with edema present in 25.9% of women at 6 or more years after BCT and seroma present in 3.7%. Lumpectomy site enhancement was seen in 37% of studies obtained in the first 12 months after treatment and persisted in 15% of women at 5 or more years. Rim enhancement was seen in women with seromas, whereas focal enhancement was typically seen in those without seromas. The persistence of lumpectomy site enhancement was seen in 12 of 16 women with fat necrosis, indicated by fat signal in the seroma and was seen in only five of 19 patients without fat seen in the surgery cavity (p = 0.007).

CONCLUSION. After a patient has undergone BCT, MRI shows changes in both breasts. Although the changes in our study population were greatest in the treated breast, parenchymal enhancement and cystic alteration decrease bilaterally indicating a systemic influence. Edematous changes, seroma, focal enhancement, and skin thickening were seen only in the treated breast. All posttreatment MRI findings decrease progressively, and all may persist. Lumpectomy site enhancement is most persistent in women with fat necrosis.

语种英语
WOS记录号WOS:000281180500038
引用统计
被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58969
专题北京大学临床肿瘤学院
作者单位1.Mem Sloan Kettering Canc Ctr, Breast Imaging Serv, Dept Radiol, New York, NY 10065 USA
2.Peking Univ, Sch Oncol, Bejing Inst Canc Res, Beijing Canc Hosp, Beijing 100871, Peoples R China
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GB/T 7714
Li, Jie,Dershaw, D. David,Lee, Carol F.,et al. Breast MRI After Conservation Therapy: Usual Findings in Routine Follow-Up Examinations[J]. AMERICAN JOURNAL OF ROENTGENOLOGY,2010,195(3):799-807.
APA Li, Jie,Dershaw, D. David,Lee, Carol F.,Joo, Sandra,&Morris, Elizabeth A..(2010).Breast MRI After Conservation Therapy: Usual Findings in Routine Follow-Up Examinations.AMERICAN JOURNAL OF ROENTGENOLOGY,195(3),799-807.
MLA Li, Jie,et al."Breast MRI After Conservation Therapy: Usual Findings in Routine Follow-Up Examinations".AMERICAN JOURNAL OF ROENTGENOLOGY 195.3(2010):799-807.
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