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Effective control of blood glucose status and toxicity in streptozotocin-induced diabetic rats by orally administration of vanadate in an herbal decoction
Zhang, L.2; Zhang, Y.1; Xia, Q.1; Zhao, X. M.2; Cai, H. X.2; Li, D. W.2; Yang, X. D.1; Wang, K.1; Xia, Z. L.2
关键词diabetes vanadium antioxidant
刊名FOOD AND CHEMICAL TOXICOLOGY
2008-09-01
DOI10.1016/j.fct.2008.05.040
46期:9页:2996-3002
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Food Science & Technology ; Toxicology
研究领域[WOS]Food Science & Technology ; Toxicology
关键词[WOS]VANADIUM TOXICITY ; TEA ; DAMAGE
英文摘要

Vanadium compounds have been well recognized for hypoglycemic effects, but questions remain on gastrointestinal disturbance and possible tissue vanadium accumulation thus slowing the acceptance of vanadium compounds as diabetic therapeutic agents. Our intestinal permeability and toxicity Studies of vanadium compounds have Suggested that the co-administration of vanadate with Salvia miltiorrhiza Bunge decoction could benefit the therapeutic use of hypoglycemic vanadium compounds. In the present paper, we tested the hypoglycemic effects of vanadate ingested in ail aqueous extract of S. Bunge using a streptozocin (STZ)-induced diabetic rat model. Oral administration of vanadate in S. Bunge herbal decoction produced a stable (free of hypoglycemic shock) and long-lasting (similar to 70 day) control of blood glucose Status. Effective protection of animal organs from hyperglycemic damage was also observed. As expected, the herbal extract significantly alleviated vanadium toxicity, i.e. GI stress and metal accumulation. In addition, the result Suggesting that vanadium-induced amelioration of the diabetic state appears to be secondary to the preservation of a functional portion of the pancreatic P-cells which initially survived STZ-toxicity. These Studies provide new insight into the therapeutic treatment of diabetics with vanadium Compounds. (C) 2008 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000259762100006
项目编号Z0004105040311 ; 200702029
资助机构Committee of Science and Technology of Beijing ; PostDoctoral Innovation Foundation of Shandong province
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58972
专题北京大学药学院
北京大学药学院_化学生物学系
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Natl Lab Nat & Biomimet Drugs,Dept Chem Biol, Beijing 100083, Peoples R China
2.Taishan Med Univ, Res Inst Life Sci, Tai An 271000, Shandong, Peoples R China
推荐引用方式
GB/T 7714
Zhang, L.,Zhang, Y.,Xia, Q.,et al. Effective control of blood glucose status and toxicity in streptozotocin-induced diabetic rats by orally administration of vanadate in an herbal decoction[J]. FOOD AND CHEMICAL TOXICOLOGY,2008,46(9):2996-3002.
APA Zhang, L..,Zhang, Y..,Xia, Q..,Zhao, X. M..,Cai, H. X..,...&Xia, Z. L..(2008).Effective control of blood glucose status and toxicity in streptozotocin-induced diabetic rats by orally administration of vanadate in an herbal decoction.FOOD AND CHEMICAL TOXICOLOGY,46(9),2996-3002.
MLA Zhang, L.,et al."Effective control of blood glucose status and toxicity in streptozotocin-induced diabetic rats by orally administration of vanadate in an herbal decoction".FOOD AND CHEMICAL TOXICOLOGY 46.9(2008):2996-3002.
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