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学科主题: 药学
题名:
Effective control of blood glucose status and toxicity in streptozotocin-induced diabetic rats by orally administration of vanadate in an herbal decoction
作者: Zhang, L.2; Zhang, Y.1; Xia, Q.1; Zhao, X. M.2; Cai, H. X.2; Li, D. W.2; Yang, X. D.1; Wang, K.1; Xia, Z. L.2
关键词: diabetes ; vanadium ; antioxidant
刊名: FOOD AND CHEMICAL TOXICOLOGY
发表日期: 2008-09-01
DOI: 10.1016/j.fct.2008.05.040
卷: 46, 期:9, 页:2996-3002
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Food Science & Technology ; Toxicology
研究领域[WOS]: Food Science & Technology ; Toxicology
关键词[WOS]: VANADIUM TOXICITY ; TEA ; DAMAGE
英文摘要:

Vanadium compounds have been well recognized for hypoglycemic effects, but questions remain on gastrointestinal disturbance and possible tissue vanadium accumulation thus slowing the acceptance of vanadium compounds as diabetic therapeutic agents. Our intestinal permeability and toxicity Studies of vanadium compounds have Suggested that the co-administration of vanadate with Salvia miltiorrhiza Bunge decoction could benefit the therapeutic use of hypoglycemic vanadium compounds. In the present paper, we tested the hypoglycemic effects of vanadate ingested in ail aqueous extract of S. Bunge using a streptozocin (STZ)-induced diabetic rat model. Oral administration of vanadate in S. Bunge herbal decoction produced a stable (free of hypoglycemic shock) and long-lasting (similar to 70 day) control of blood glucose Status. Effective protection of animal organs from hyperglycemic damage was also observed. As expected, the herbal extract significantly alleviated vanadium toxicity, i.e. GI stress and metal accumulation. In addition, the result Suggesting that vanadium-induced amelioration of the diabetic state appears to be secondary to the preservation of a functional portion of the pancreatic P-cells which initially survived STZ-toxicity. These Studies provide new insight into the therapeutic treatment of diabetics with vanadium Compounds. (C) 2008 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: Z0004105040311 ; 200702029
项目资助者: Committee of Science and Technology of Beijing ; PostDoctoral Innovation Foundation of Shandong province
WOS记录号: WOS:000259762100006
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58972
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Natl Lab Nat & Biomimet Drugs,Dept Chem Biol, Beijing 100083, Peoples R China
2.Taishan Med Univ, Res Inst Life Sci, Tai An 271000, Shandong, Peoples R China

Recommended Citation:
Zhang, L.,Zhang, Y.,Xia, Q.,et al. Effective control of blood glucose status and toxicity in streptozotocin-induced diabetic rats by orally administration of vanadate in an herbal decoction[J]. FOOD AND CHEMICAL TOXICOLOGY,2008,46(9):2996-3002.
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