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Potentiating effect of diltiazem on pentobarbital-induced hypnosis is augmented by serotonergic system: The TMN and VLPO as key elements in the pathway
Zhao, Xin1,2; Cui, Xiang-Yu1; Wang, Li-En1; Zhang, Yong-He1
关键词Diltiazem Pentobarbital Serotonergic system Sleep TMN VLPO
刊名NEUROPHARMACOLOGY
2009-05-01
DOI10.1016/j.neuropharm.2009.01.017
56期:6-7页:937-943
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]VENTROLATERAL PREOPTIC NUCLEUS ; SLEEP-PROMOTING NEURONS ; C-FOS ; REM-SLEEP ; IN-VITRO ; T-TYPE ; HYPOTHALAMIC REGULATION ; CHOLINERGIC NEURONS ; CHANNEL BLOCKERS ; RAPHE NEURONS
英文摘要

To investigate the mechanism by which L-type Ca2+ channel blockers exerted potentiating effects on pentobarbital-induced hypnosis, the present study was undertaken to determine if the interaction of diltiazem and serotonergic system influences the architecture of pentobarbital sleep in rats and examined c-Fos expression in the ventrolaterai preoptic nucleus (VLPO) and the tuberomammillary nucleus (TMN). The polysomnogram consisting of EEG and EMG was recorded for analyzing sleep architecture. The results showed that diltiazem (2.0 and 5.0 mg/kg, p.o.)increased both total pentobarbital sleep and slow wave sleep (SWS), but decreased rapid eye movement (REM) sleep. These effects were potentiated by 5-hydroxytryptophan (5-HTP), a precursor of serotonin, but abolished by p-chlorophenylalanine (PCPA), an inhibitor of tryptophan hydroxylase. Diltiazem (1 mg/kg, p.o.) or 5-HTP (2 mg/kg, i.p.) alone did not change the architecture of pentobarbital sleep and pentobarbital-induced c-Fos expression in the VLPO and the TMN, but co-administration of them significantly increased both total pentobarbital sleep and SWS, whereas decreased REM sleep, with increasing c-Fos expression in the VLPO and concomitantly decreasing c-Fos expression in the TMN. These findings indicate that the serotonergic system may be involved in the augmentative effect of diltiazem on pentobarbital sleep and the VLPO-TMN neuronal circuit may play a key role. (C) 2009 Published by Elsevier Ltd.

语种英语
WOS记录号WOS:000266702200002
项目编号30772556 ; 2008A610076
资助机构National Nature Science Foundation of China (NSFC) ; Research Fund of Janssen Research Council (JRCC) ; National &prime ; 985 Project&prime ; in Peking University ; Ningbo Natural Science Foundation ; Foundation of Zhejiang Educational Committee
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58973
专题北京大学基础医学院_药理学系
北京大学医学部管理机构_医学部
北京大学基础医学院
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100191, Peoples R China
2.Ningbo Univ, Sch Med Sci, Dept Pharmacol, Ningbo 315211, Zhejiang, Peoples R China
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GB/T 7714
Zhao, Xin,Cui, Xiang-Yu,Wang, Li-En,et al. Potentiating effect of diltiazem on pentobarbital-induced hypnosis is augmented by serotonergic system: The TMN and VLPO as key elements in the pathway[J]. NEUROPHARMACOLOGY,2009,56(6-7):937-943.
APA Zhao, Xin,Cui, Xiang-Yu,Wang, Li-En,&Zhang, Yong-He.(2009).Potentiating effect of diltiazem on pentobarbital-induced hypnosis is augmented by serotonergic system: The TMN and VLPO as key elements in the pathway.NEUROPHARMACOLOGY,56(6-7),937-943.
MLA Zhao, Xin,et al."Potentiating effect of diltiazem on pentobarbital-induced hypnosis is augmented by serotonergic system: The TMN and VLPO as key elements in the pathway".NEUROPHARMACOLOGY 56.6-7(2009):937-943.
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