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学科主题: 基础医学
题名:
Potentiating effect of diltiazem on pentobarbital-induced hypnosis is augmented by serotonergic system: The TMN and VLPO as key elements in the pathway
作者: Zhao, Xin1,2; Cui, Xiang-Yu1; Wang, Li-En1; Zhang, Yong-He1
关键词: Diltiazem ; Pentobarbital ; Serotonergic system ; Sleep ; TMN ; VLPO
刊名: NEUROPHARMACOLOGY
发表日期: 2009-05-01
DOI: 10.1016/j.neuropharm.2009.01.017
卷: 56, 期:6-7, 页:937-943
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]: VENTROLATERAL PREOPTIC NUCLEUS ; SLEEP-PROMOTING NEURONS ; C-FOS ; REM-SLEEP ; IN-VITRO ; T-TYPE ; HYPOTHALAMIC REGULATION ; CHOLINERGIC NEURONS ; CHANNEL BLOCKERS ; RAPHE NEURONS
英文摘要:

To investigate the mechanism by which L-type Ca2+ channel blockers exerted potentiating effects on pentobarbital-induced hypnosis, the present study was undertaken to determine if the interaction of diltiazem and serotonergic system influences the architecture of pentobarbital sleep in rats and examined c-Fos expression in the ventrolaterai preoptic nucleus (VLPO) and the tuberomammillary nucleus (TMN). The polysomnogram consisting of EEG and EMG was recorded for analyzing sleep architecture. The results showed that diltiazem (2.0 and 5.0 mg/kg, p.o.)increased both total pentobarbital sleep and slow wave sleep (SWS), but decreased rapid eye movement (REM) sleep. These effects were potentiated by 5-hydroxytryptophan (5-HTP), a precursor of serotonin, but abolished by p-chlorophenylalanine (PCPA), an inhibitor of tryptophan hydroxylase. Diltiazem (1 mg/kg, p.o.) or 5-HTP (2 mg/kg, i.p.) alone did not change the architecture of pentobarbital sleep and pentobarbital-induced c-Fos expression in the VLPO and the TMN, but co-administration of them significantly increased both total pentobarbital sleep and SWS, whereas decreased REM sleep, with increasing c-Fos expression in the VLPO and concomitantly decreasing c-Fos expression in the TMN. These findings indicate that the serotonergic system may be involved in the augmentative effect of diltiazem on pentobarbital sleep and the VLPO-TMN neuronal circuit may play a key role. (C) 2009 Published by Elsevier Ltd.

语种: 英语
所属项目编号: 30772556 ; 2008A610076
项目资助者: National Nature Science Foundation of China (NSFC) ; Research Fund of Janssen Research Council (JRCC) ; National &prime ; 985 Project&prime ; in Peking University ; Ningbo Natural Science Foundation ; Foundation of Zhejiang Educational Committee
WOS记录号: WOS:000266702200002
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58973
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100191, Peoples R China
2.Ningbo Univ, Sch Med Sci, Dept Pharmacol, Ningbo 315211, Zhejiang, Peoples R China

Recommended Citation:
Zhao, Xin,Cui, Xiang-Yu,Wang, Li-En,et al. Potentiating effect of diltiazem on pentobarbital-induced hypnosis is augmented by serotonergic system: The TMN and VLPO as key elements in the pathway[J]. NEUROPHARMACOLOGY,2009,56(6-7):937-943.
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