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Nitric oxide inhibitory flavonoids from traditional Chinese medicine formula Baoyuan Decoction
Ma, Xiaoli; Yu, Qian; Guo, Xiaoyu; Zeng, Kewu; Zhao, Mingbo; Tu, Pengfei; Jiang, Yong
关键词Flavonoids Baoyuan Decoction Traditional Chinese medicine formula NO inhibition UPLC-Q-trap-MS
刊名FITOTERAPIA
2015-06-01
DOI10.1016/j.fitote.2015.04.011
103页:252-259
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
资助者National Natural Sciences Foundation of China ; National Key Technology R&amp ; D Program "New Drug Innovation" of China ; National Natural Sciences Foundation of China ; National Key Technology R&amp ; D Program "New Drug Innovation" of China
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]GLYCYRRHIZA-URALENSIS ; ASTRAGALUS-MEMBRANACEUS ; ABSOLUTE-CONFIGURATION ; CIRCULAR-DICHROISM ; LICORICE ; DERIVATIVES ; GLYCOSIDES ; ROOTS ; ISOFLAVONOIDS ; CONSTITUENTS
英文摘要

Three new flavonoid glycosides, (3R)-(+)-isomucronulatol-2′-O-beta-D-glucopyranoside (I), (3R)-(-)-isomucronulatol-7-O-beta-D-apiofuranosyl(1 --> 2)-beta-D-glucopyranoside (2), and (2S)-(-)-7,8-dihydroxylflavanone-4′-O-beta-D-apiofuranosyl(1 --> 2)-beta-D-glucopyranoside (3), along with eight flavanones (4, 8, 10, 12, 15, 16, 21, and 24), four isoflavones (5, 11, 13, and 23), four chalcones (6, 14, 17, and 18), two isoflavans (19-20), one flavone (7), one flavonol (9), and one dihydrochalcone (22) were isolated from Baoyuan Decoction (BYD), a traditional Chinese medicine formula. The structures of the new compounds were established by detailed analysis of NMR and HRESIMS spectroscopic data, and their absolute configurations were determined by electronic circular dichroism (ECD) data. The inhibitory effects of the isolates were evaluated on nitric oxide production in lipopolysaccharide activated RAW 264.7 macrophage cells. Compounds 6, 9, and 10 showed the significant inhibitory activities, with IC50 values of 1.4, 13.8, and 9.3 mu M, respectively, comparable to or even better than the positive control, quercetin (IC50, 16.5 mu M). The assignment of these isolated flavonoids was achieved using UPLC-Q-trap-MS, and the results suggested that they were originated from Astragalus membranaceus and Glycyrrhiza uralensis. (C) 2015 Elsevier B.V. All rights reserved.

语种英语
所属项目编号81222051 ; 2012ZX09301002-002-002 ; 2012ZX09304-005
资助者National Natural Sciences Foundation of China ; National Key Technology R&amp ; D Program "New Drug Innovation" of China ; National Natural Sciences Foundation of China ; National Key Technology R&amp ; D Program "New Drug Innovation" of China
WOS记录号WOS:000356738800031
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58975
专题北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Ma, Xiaoli,Yu, Qian,Guo, Xiaoyu,et al. Nitric oxide inhibitory flavonoids from traditional Chinese medicine formula Baoyuan Decoction[J]. FITOTERAPIA,2015,103:252-259.
APA Ma, Xiaoli.,Yu, Qian.,Guo, Xiaoyu.,Zeng, Kewu.,Zhao, Mingbo.,...&Jiang, Yong.(2015).Nitric oxide inhibitory flavonoids from traditional Chinese medicine formula Baoyuan Decoction.FITOTERAPIA,103,252-259.
MLA Ma, Xiaoli,et al."Nitric oxide inhibitory flavonoids from traditional Chinese medicine formula Baoyuan Decoction".FITOTERAPIA 103(2015):252-259.
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