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学科主题: 药学
题名:
Nitric oxide inhibitory flavonoids from traditional Chinese medicine formula Baoyuan Decoction
作者: Ma, Xiaoli; Yu, Qian; Guo, Xiaoyu; Zeng, Kewu; Zhao, Mingbo; Tu, Pengfei; Jiang, Yong
关键词: Flavonoids ; Baoyuan Decoction ; Traditional Chinese medicine formula ; NO inhibition ; UPLC-Q-trap-MS
刊名: FITOTERAPIA
发表日期: 2015-06-01
DOI: 10.1016/j.fitote.2015.04.011
卷: 103, 页:252-259
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: GLYCYRRHIZA-URALENSIS ; ASTRAGALUS-MEMBRANACEUS ; ABSOLUTE-CONFIGURATION ; CIRCULAR-DICHROISM ; LICORICE ; DERIVATIVES ; GLYCOSIDES ; ROOTS ; ISOFLAVONOIDS ; CONSTITUENTS
英文摘要:

Three new flavonoid glycosides, (3R)-(+)-isomucronulatol-2′-O-beta-D-glucopyranoside (I), (3R)-(-)-isomucronulatol-7-O-beta-D-apiofuranosyl(1 --> 2)-beta-D-glucopyranoside (2), and (2S)-(-)-7,8-dihydroxylflavanone-4′-O-beta-D-apiofuranosyl(1 --> 2)-beta-D-glucopyranoside (3), along with eight flavanones (4, 8, 10, 12, 15, 16, 21, and 24), four isoflavones (5, 11, 13, and 23), four chalcones (6, 14, 17, and 18), two isoflavans (19-20), one flavone (7), one flavonol (9), and one dihydrochalcone (22) were isolated from Baoyuan Decoction (BYD), a traditional Chinese medicine formula. The structures of the new compounds were established by detailed analysis of NMR and HRESIMS spectroscopic data, and their absolute configurations were determined by electronic circular dichroism (ECD) data. The inhibitory effects of the isolates were evaluated on nitric oxide production in lipopolysaccharide activated RAW 264.7 macrophage cells. Compounds 6, 9, and 10 showed the significant inhibitory activities, with IC50 values of 1.4, 13.8, and 9.3 mu M, respectively, comparable to or even better than the positive control, quercetin (IC50, 16.5 mu M). The assignment of these isolated flavonoids was achieved using UPLC-Q-trap-MS, and the results suggested that they were originated from Astragalus membranaceus and Glycyrrhiza uralensis. (C) 2015 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 81222051 ; 2012ZX09301002-002-002 ; 2012ZX09304-005
项目资助者: National Natural Sciences Foundation of China ; National Key Technology R&amp ; D Program "New Drug Innovation" of China
WOS记录号: WOS:000356738800031
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58975
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Ma, Xiaoli,Yu, Qian,Guo, Xiaoyu,et al. Nitric oxide inhibitory flavonoids from traditional Chinese medicine formula Baoyuan Decoction[J]. FITOTERAPIA,2015,103:252-259.
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