IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科
学科主题临床医学
Anti-myeloperoxidase IgG subclass distribution and avidity in sera from patients with propylthiouracil-induced antineutrophil cytoplasmic antibodies associated vasculitis
Gao, Y; Ye, H; Yu, F; Guo, XH; Zhao, MH
关键词myeloperoxidase ANCA IgG subclass avidity propylthiouracil vasculitis
刊名CLINICAL IMMUNOLOGY
2005-10-01
DOI10.1016/j.clim.2005.06.002
117期:1页:87-93
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]SYSTEMIC VASCULITIS ; WEGENERS GRANULOMATOSIS ; AUTOANTIBODIES ANCA ; CHINESE PATIENTS ; MYELOPEROXIDASE ; ANTIGENS ; AFFINITY ; PREVALENCE ; THERAPY
英文摘要

Objective: Propylthiouracil (PTU) could induce MPO-ANCA-positive vasculitis. The aim of this study was to compare the IgG subclass distribution and avidity of MPO-ANCA in sera from patients with primary ANCA-associated vasculitis (AASV) and PTU-induced vasculitis.

Methods: Nineteen patients with primary AASV with MPO-ANCA and thirteen patients with PTU-induced vasculitis were enrolled in the current study. Sera in both active phase and remission were collected. Anti-MPO IgG subclasses were detected by antigen specific ELISAs using specific monoclonal antibodies as second antibodies, and MPO-ANCA avidity was assessed by antigen-inhibition ELISAs.

Results: In primary AASV, all four anti-MPO IgG subclasses could be detected in active phase with IgG1 (100%), IgG2 (73.7%), IgG3 (63.2%) and IgG4 (94.7%), and in remission, IgG1 and IgG4 subclasses in most patients remained positive. However, in PTU-induced vasculitis, anti-MPO IgG3 subclass could not be detected, the anti-MPO IgG subclasses in active phase were IgG1 (100%), IgG2 (61.5%) and IgG4 (46.2%). Furthermore, five out of the six patients (88.8%) with PTU-induced vasculitis with positive IgG4 subclass in active phase turned to negative in remission, however, only eight out of the fourteen patients (57.1%) with primary AASV turned to negative. The median avidity constant of MPO-ANCA was 56 (8.96 to > 140) x 10(7) Mol/l for patients with primary AASV and 0.7 (< 0.28 to > 140) x 10(7) Mol/l for patients with PTU-induced vasculitis respectively. Furthermore, the relative levels of MPO-ANCA avidity were associated with elevation of ESR in primary AASV and were associated with BVAS scores in patients with PTU-induced vasculitis, respectively.

Conclusion: MPO-ANCA IgG subclass distribution and avidity were different between patients with primary AASV and PTU-induced vasculitis. It was suggested that the mechanism of ANCA production in PTU-induced vasculitis was different from that in primary AASV, and the avidity of MPO-ANCA might be associated with disease activity. (c) 2005 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000231942600013
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58983
Collection北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Hosp 1, Dept Nephrol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Endocrinol, Beijing 100034, Peoples R China
Recommended Citation
GB/T 7714
Gao, Y,Ye, H,Yu, F,et al. Anti-myeloperoxidase IgG subclass distribution and avidity in sera from patients with propylthiouracil-induced antineutrophil cytoplasmic antibodies associated vasculitis[J]. CLINICAL IMMUNOLOGY,2005,117(1):87-93.
APA Gao, Y,Ye, H,Yu, F,Guo, XH,&Zhao, MH.(2005).Anti-myeloperoxidase IgG subclass distribution and avidity in sera from patients with propylthiouracil-induced antineutrophil cytoplasmic antibodies associated vasculitis.CLINICAL IMMUNOLOGY,117(1),87-93.
MLA Gao, Y,et al."Anti-myeloperoxidase IgG subclass distribution and avidity in sera from patients with propylthiouracil-induced antineutrophil cytoplasmic antibodies associated vasculitis".CLINICAL IMMUNOLOGY 117.1(2005):87-93.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Gao, Y]'s Articles
[Ye, H]'s Articles
[Yu, F]'s Articles
百度学术
百度学术Similar articles in
[Gao, Y]'s Articles
[Ye, H]'s Articles
[Yu, F]'s Articles
必应学术
必应学术Similar articles in
[Gao, Y]'s Articles
[Ye, H]'s Articles
[Yu, F]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.