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学科主题: 临床医学
题名:
Anti-myeloperoxidase IgG subclass distribution and avidity in sera from patients with propylthiouracil-induced antineutrophil cytoplasmic antibodies associated vasculitis
作者: Gao, Y; Ye, H; Yu, F; Guo, XH; Zhao, MH
关键词: myeloperoxidase ; ANCA ; IgG subclass ; avidity ; propylthiouracil ; vasculitis
刊名: CLINICAL IMMUNOLOGY
发表日期: 2005-10-01
DOI: 10.1016/j.clim.2005.06.002
卷: 117, 期:1, 页:87-93
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: SYSTEMIC VASCULITIS ; WEGENERS GRANULOMATOSIS ; AUTOANTIBODIES ANCA ; CHINESE PATIENTS ; MYELOPEROXIDASE ; ANTIGENS ; AFFINITY ; PREVALENCE ; THERAPY
英文摘要:

Objective: Propylthiouracil (PTU) could induce MPO-ANCA-positive vasculitis. The aim of this study was to compare the IgG subclass distribution and avidity of MPO-ANCA in sera from patients with primary ANCA-associated vasculitis (AASV) and PTU-induced vasculitis.

Methods: Nineteen patients with primary AASV with MPO-ANCA and thirteen patients with PTU-induced vasculitis were enrolled in the current study. Sera in both active phase and remission were collected. Anti-MPO IgG subclasses were detected by antigen specific ELISAs using specific monoclonal antibodies as second antibodies, and MPO-ANCA avidity was assessed by antigen-inhibition ELISAs.

Results: In primary AASV, all four anti-MPO IgG subclasses could be detected in active phase with IgG1 (100%), IgG2 (73.7%), IgG3 (63.2%) and IgG4 (94.7%), and in remission, IgG1 and IgG4 subclasses in most patients remained positive. However, in PTU-induced vasculitis, anti-MPO IgG3 subclass could not be detected, the anti-MPO IgG subclasses in active phase were IgG1 (100%), IgG2 (61.5%) and IgG4 (46.2%). Furthermore, five out of the six patients (88.8%) with PTU-induced vasculitis with positive IgG4 subclass in active phase turned to negative in remission, however, only eight out of the fourteen patients (57.1%) with primary AASV turned to negative. The median avidity constant of MPO-ANCA was 56 (8.96 to > 140) x 10(7) Mol/l for patients with primary AASV and 0.7 (< 0.28 to > 140) x 10(7) Mol/l for patients with PTU-induced vasculitis respectively. Furthermore, the relative levels of MPO-ANCA avidity were associated with elevation of ESR in primary AASV and were associated with BVAS scores in patients with PTU-induced vasculitis, respectively.

Conclusion: MPO-ANCA IgG subclass distribution and avidity were different between patients with primary AASV and PTU-induced vasculitis. It was suggested that the mechanism of ANCA production in PTU-induced vasculitis was different from that in primary AASV, and the avidity of MPO-ANCA might be associated with disease activity. (c) 2005 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000231942600013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58983
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Nephrol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Endocrinol, Beijing 100034, Peoples R China

Recommended Citation:
Gao, Y,Ye, H,Yu, F,et al. Anti-myeloperoxidase IgG subclass distribution and avidity in sera from patients with propylthiouracil-induced antineutrophil cytoplasmic antibodies associated vasculitis[J]. CLINICAL IMMUNOLOGY,2005,117(1):87-93.
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