IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Variations of MicroRNAs in Human Placentas and Plasma From Preeclamptic Pregnancy
Xu, Peng1,4; Zhao, Yangyu2; Liu, Ming1; Wang, Yongqing2; Wang, Hao1,4; Li, Yu-xia1; Zhu, Xiaoming3; Yao, Yuanqing3; Wang, Haibin1; Qiao, Jie2; Ji, Lei1; Wang, Yan-ling1
关键词microRNAs placenta plasma preeclampsia miR-17-92
刊名HYPERTENSION
2014-06-01
DOI10.1161/HYPERTENSIONAHA.113.02647
63期:6页:1276-1284
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Peripheral Vascular Disease
资助者Chinese National Special Fund for Basic Research Projects ; National Natural Sciences Foundation ; Chinese National Special Fund for Basic Research Projects ; National Natural Sciences Foundation
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]MIR-17-92 CLUSTER ; EXPRESSION ; MIR-210 ; TARGETS ; CELLS ; PROLIFERATION ; TROPHOBLASTS ; RECEPTOR ; DISEASE ; CANCER
英文摘要

Preeclampsia is a major cause of maternal and fetal mortality and morbidity worldwide. The differential expression of several microRNAs (miRNAs) has been found in preeclamptic placentas. However, great conflict exists regarding this aspect, and detailed examinations have largely been lacking of miRNA profiles in different parts of the placenta and in maternal plasma of women with this disorder. In this study, a total of 9 downregulated miRNAs (miR-195, miR-223, miR-218, miR-17, miR-18a, miR-19b1, miR-92a1, miR-379, and miR-411) and 7 upregulated miRNAs (miR-210, miR-30a-3p, miR-518b, miR-524, miR-17-3p, miR-151, and miR-193b) were identified in severe preeclampsia (sPE) placentas when compared with normal pregnant controls. In addition, sampling position in the chorionic or basal plate of placenta led to evident variations in differential miRNAs of sPE placentas. In a prospective pregnant cohort, we found that the circulating levels of 3 members of miR-17-92 cluster (ie, miR-18a, miR-19b1, and miR-92a1) were significantly lower, whereas that of miR-210 was higher in sPE patients than those in normal controls at gestational weeks 15 to 18 and at term. The results of in situ hybridization revealed the localization of miR-18a, miR-92a1, and miR-210 in various subtypes of placental trophoblasts and endothelial cells. In human trophoblast cell line, HTR8/SVneo cells, miR-18a could promote trophoblast cell invasion via targeting and suppressing Smad2 expression. This study provides fundamental evidences for exploring the roles of miRNAs in the pathogenesis of preeclampsia.

语种英语
所属项目编号2011CB944400 ; 81025004 ; 81361128008
资助者Chinese National Special Fund for Basic Research Projects ; National Natural Sciences Foundation ; Chinese National Special Fund for Basic Research Projects ; National Natural Sciences Foundation
WOS记录号WOS:000335491900164
引用统计
被引频次:65[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58991
专题北京大学第三临床医学院
作者单位1.Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing 100101, Peoples R China
2.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100871, Peoples R China
3.Fourth Mil Med Univ, Tangdu Hosp, Dept Obstet & Gynecol, Xian 710032, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Xu, Peng,Zhao, Yangyu,Liu, Ming,et al. Variations of MicroRNAs in Human Placentas and Plasma From Preeclamptic Pregnancy[J]. HYPERTENSION,2014,63(6):1276-1284.
APA Xu, Peng.,Zhao, Yangyu.,Liu, Ming.,Wang, Yongqing.,Wang, Hao.,...&Wang, Yan-ling.(2014).Variations of MicroRNAs in Human Placentas and Plasma From Preeclamptic Pregnancy.HYPERTENSION,63(6),1276-1284.
MLA Xu, Peng,et al."Variations of MicroRNAs in Human Placentas and Plasma From Preeclamptic Pregnancy".HYPERTENSION 63.6(2014):1276-1284.
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