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学科主题: 临床医学
题名:
Baseline predictors of virological response for chronic hepatitis B patients
作者: Wu, Xue-Jie; Wang, Yan; Chen, Ji; Wang, Gui-Qiang
关键词: Chronic hepatitis B ; Hepatitis B virus ; Predictors ; Virological response ; Peginterferon
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2009-09-14
DOI: 10.3748/wjg.15.4311
卷: 15, 期:34, 页:4311-4315
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: INTERFERON THERAPY ; THYROID-HORMONES ; CONTROLLED TRIAL ; ALPHA-INTERFERON ; VIRUS-INFECTION ; HBEAG ; LAMIVUDINE ; SEROCONVERSION ; PROGRESSION ; GENOTYPES
英文摘要:

AIM: To determine which baseline factors of chronic hepatitis B patients are predictive of virological response to Peginterferon alpha-2b therapy.

METHODS: A total of 21 HBeAg-positive chronic hepatitis B (CHB) patients treated with Peginterferon alpha-2b were recruited. They were treated with Peginterferon alpha-2b (0.5-1.0 mu g/kg per week) for 24 wk and followed up for 24 wk. Clinical and laboratory data of the patients were determined at pretreatment and at week 12, at 24 during treatment, and at week 48 during follow up.

RESULTS: Ten patients achieved a virological response at the end of treatment. Their baseline serum alanine aminotransferase (ALT), thyroid-stimulating hormone (TSH), and total thyroxin (TT4) levels were significantly different from those who failed treatment. The positive predictive values (PPV) and negative predictive values (NPV) of ALT, TSH, and TT4 were 75% and 89 %, 75% and 89 %, and 75% and 75%, respectively. Moreover, combinations of the baseline ALT and TT4, ALT and TSH, TT4 and TSH levels had much higher PPV and NPV (86% and 88%, 89% and 100%, 83% and 100%, respectively).

CONCLUSION: Baseline serum ALT, TSH, and TT4 levels, especially in combination, have high predictive values of virological response to Peginterferon alpha-2b in HBeAg-positive CHB patients. (C) 2009 The WJG Press and Baishideng. All rights reserved.

语种: 英语
所属项目编号: 2007CB512800 ; 30771905 ; 008ZX10002-008 ; D08050700650803
项目资助者: "973" Program ; National Natural Science Foundation of China ; Mega-projects of Science Research ; Beijing Municipal Science &amp ; Technology Commission
WOS记录号: WOS:000269814900011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/58997
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

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作者单位: Peking Univ, Hosp 1, Ctr Liver Dis, Dept Infect Dis, Beijing 100034, Peoples R China

Recommended Citation:
Wu, Xue-Jie,Wang, Yan,Chen, Ji,et al. Baseline predictors of virological response for chronic hepatitis B patients[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2009,15(34):4311-4315.
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