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学科主题临床医学
Baseline predictors of virological response for chronic hepatitis B patients
Wu, Xue-Jie; Wang, Yan; Chen, Ji; Wang, Gui-Qiang
关键词Chronic hepatitis B Hepatitis B virus Predictors Virological response Peginterferon
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2009-09-14
DOI10.3748/wjg.15.4311
15期:34页:4311-4315
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]INTERFERON THERAPY ; THYROID-HORMONES ; CONTROLLED TRIAL ; ALPHA-INTERFERON ; VIRUS-INFECTION ; HBEAG ; LAMIVUDINE ; SEROCONVERSION ; PROGRESSION ; GENOTYPES
英文摘要

AIM: To determine which baseline factors of chronic hepatitis B patients are predictive of virological response to Peginterferon alpha-2b therapy.

METHODS: A total of 21 HBeAg-positive chronic hepatitis B (CHB) patients treated with Peginterferon alpha-2b were recruited. They were treated with Peginterferon alpha-2b (0.5-1.0 mu g/kg per week) for 24 wk and followed up for 24 wk. Clinical and laboratory data of the patients were determined at pretreatment and at week 12, at 24 during treatment, and at week 48 during follow up.

RESULTS: Ten patients achieved a virological response at the end of treatment. Their baseline serum alanine aminotransferase (ALT), thyroid-stimulating hormone (TSH), and total thyroxin (TT4) levels were significantly different from those who failed treatment. The positive predictive values (PPV) and negative predictive values (NPV) of ALT, TSH, and TT4 were 75% and 89 %, 75% and 89 %, and 75% and 75%, respectively. Moreover, combinations of the baseline ALT and TT4, ALT and TSH, TT4 and TSH levels had much higher PPV and NPV (86% and 88%, 89% and 100%, 83% and 100%, respectively).

CONCLUSION: Baseline serum ALT, TSH, and TT4 levels, especially in combination, have high predictive values of virological response to Peginterferon alpha-2b in HBeAg-positive CHB patients. (C) 2009 The WJG Press and Baishideng. All rights reserved.

语种英语
WOS记录号WOS:000269814900011
项目编号2007CB512800 ; 30771905 ; 008ZX10002-008 ; D08050700650803
资助机构"973" Program ; National Natural Science Foundation of China ; Mega-projects of Science Research ; Beijing Municipal Science &amp ; Technology Commission
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58997
专题北京大学第一临床医学院_感染疾病科
作者单位Peking Univ, Hosp 1, Ctr Liver Dis, Dept Infect Dis, Beijing 100034, Peoples R China
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GB/T 7714
Wu, Xue-Jie,Wang, Yan,Chen, Ji,et al. Baseline predictors of virological response for chronic hepatitis B patients[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2009,15(34):4311-4315.
APA Wu, Xue-Jie,Wang, Yan,Chen, Ji,&Wang, Gui-Qiang.(2009).Baseline predictors of virological response for chronic hepatitis B patients.WORLD JOURNAL OF GASTROENTEROLOGY,15(34),4311-4315.
MLA Wu, Xue-Jie,et al."Baseline predictors of virological response for chronic hepatitis B patients".WORLD JOURNAL OF GASTROENTEROLOGY 15.34(2009):4311-4315.
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