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Effects of Ganoderma lucidum spores on sialoadenitis of nonobese diabetic mice
Qi Ge1; Hua Hong2; Gao Yan3; Lin Qin4; Yu Guang-yan1
关键词nonobese diabetes sialoadenitis ganoderma lucidum spores
刊名CHINESE MEDICAL JOURNAL
2009-03-05
DOI10.3760/cma.j.issn.0366-6999.2009.05.013
122期:5页:556-560
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]PRIMARY SJOGRENS-SYNDROME ; SALIVARY-GLANDS ; NOD MICE ; APOPTOSIS ; EXPRESSION ; PILOCARPINE ; PROGRESSION ; XEROSTOMIA
英文摘要

Background Sjogren syndrome (SS) is a systematic autoimmune disease, on which traditional therapeutic agents show limited effect. More effective agents with longer-lasting and fewer side effects are needed in the clinic. The aim of this study was to investigate the effects of Ganoderma lucindum spores (GLS) on sialoadenitis of nonobese diabetic (NOD) mice.

Methods Thirty-two female NOD mice were assigned randomly into 4 groups: low-dose GLS-treated (L-GLS) group and high-dose GLS-treated (H-GLS) group, a dexamethasone group, and a normal saline (NS) control group. Stimulated total saliva flow rate (STFR), area of lymphocytic infiltration in submandibular glands and ratios of CD4(+) and CD8(+) T lymphocytes and B lymphocytes in peripheral blood as well as apoptosis of these subsets and serum IgG level were tested after 10 weeks of treatments. Differences among the groups were analyzed by one-way analysis of variance (ANOVA), Student-Newman-Keuls Test (SNK) was used between each two groups and a P < 0.05 was considered statistically significant.

Results STFR of the high-dose GLS group increased significantly after a 10-week treatment compared with those of the NS control group (P < 0.05). The incidence of sialoadenitis in GLS-treated NOD mice groups showed no significant difference compared with the control group (P > 0.05), but the area of lymphocytic foci in both the H-GLS and L-GLS groups decreased significantly to 50% of the NS control group (P < 0.05); the ratio of CD4(+)/CD8(+) T lymphocytes and apoptosis of B lymphocytes of NOD mice with sialoadenitis were less and apoptosis of CD4(+) and CD8(+) T lymphocytes were significantly increased compared with the control group (P < 0.05). After pretreatment with H-GLS before sialoadenitis onset, the ratio of CD4(+)/CD8(+) T lymphocyte and the serum IgG levels of NOD mice decreased significantly (P < 0.05).

Conclusions Pretreatment with H-GLS can relieve symptoms of sialoadenitis in NOD mice. GLS has some protective effects on sialoadenitis in NOD mice through increasing STFR and decreasing the area of lymphocytic foci by regulating the ratio of CD4(+)/CD8(+) T and apoptosis of B lymphocytes.

语种英语
WOS记录号WOS:000263997400014
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/58999
专题北京大学口腔医学院_口腔病理科
北京大学口腔医学院_口腔黏膜科
北京大学口腔医学院_检验科
北京大学口腔医学院_外科
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dept Tradit Chinese Med & Oral Med, Beijing 100081, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China
4.Peking Univ, Sch & Hosp Stomatol, Dept Lab Examinat, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Qi Ge,Hua Hong,Gao Yan,et al. Effects of Ganoderma lucidum spores on sialoadenitis of nonobese diabetic mice[J]. CHINESE MEDICAL JOURNAL,2009,122(5):556-560.
APA Qi Ge,Hua Hong,Gao Yan,Lin Qin,&Yu Guang-yan.(2009).Effects of Ganoderma lucidum spores on sialoadenitis of nonobese diabetic mice.CHINESE MEDICAL JOURNAL,122(5),556-560.
MLA Qi Ge,et al."Effects of Ganoderma lucidum spores on sialoadenitis of nonobese diabetic mice".CHINESE MEDICAL JOURNAL 122.5(2009):556-560.
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