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学科主题: 临床医学
题名:
Comparison of Clinicopathologic Characteristics of Urothelial Carcinoma Between Patients After Renal Transplantation and on Dialysis
作者: Zhang, Bo1,2,3; Shen, Cheng1,2,3; Han, Wen-ke1,2,3; Yu, Wei1,2,3
关键词: Renal transplantation ; Dialysis ; Urothelial carcinoma
刊名: TRANSPLANTATION
发表日期: 2014-09-15
DOI: 10.1097/TP.0000000000000112
卷: 98, 期:5, 页:552-556
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Surgery ; Transplantation
研究领域[WOS]: Immunology ; Surgery ; Transplantation
关键词[WOS]: TRANSITIONAL-CELL CARCINOMA ; ARISTOLOCHIC ACID NEPHROPATHY ; KIDNEY-TRANSPLANTATION ; FOLLOW-UP ; CHINESE HERBALISTS ; UREMIC PATIENTS ; BLADDER-CANCER ; URINARY-TRACT ; RECIPIENTS ; FANGCHI
英文摘要:

Background Urothelial carcinoma (UC) is a common complication after renal replacement therapy (RRT) among Chinese end-stage renal disease (ESRD) patients. It is unclear whether there are any differences in the clinicopathologic characteristics of UC between renal transplantation (RT) and dialysis patients; such differences could impact RRT modality selection.

Methods We retrospectively reviewed clinicopathologic data for 27 RT patients and 40 dialysis patients who were diagnosed with UC in our center to explore differences in the clinicopathologic characteristics of UC and prognoses between the two groups.

Results The median follow-up period was 92 months (2-137) for the RT group and 71 months (18-155) for the dialysis group. The demographic and baseline data showed no significant differences between the two groups. Upper urinary tract UC (UUC) occurred more frequently in the RT group (22 UUCs in 39 UCs), whereas bladder UC (BUC) predominated in the dialysis group (33 BUCs in 49 UCs) (P=0.025). The pathologic grading in the RT group was significantly higher than that in the dialysis group (P=0.046 for WHO1973 grading, P=0.026 for WHO2004 grading), whereas the difference in tumor stage was not significant (P=0.089). The RT group manifested a higher recurrence rate than the dialysis group (P=0.024). However, the overall and cancer-specific survival rates between the two groups were not significantly different (P=0.239 and P=0.818, respectively).

Conclusion Certain traits of UC, including tumor site, pathologic grading, and recurrence-free survival, were notably different between RT and dialysis patients, but the overall and cancer-specific survival rates were similar.

语种: 英语
WOS记录号: WOS:000341854800024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59003
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Inst Urol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Dept Urol, Beijing 100034, Peoples R China
3.Natl Urol Canc Ctr, Beijing, Peoples R China

Recommended Citation:
Zhang, Bo,Shen, Cheng,Han, Wen-ke,et al. Comparison of Clinicopathologic Characteristics of Urothelial Carcinoma Between Patients After Renal Transplantation and on Dialysis[J]. TRANSPLANTATION,2014,98(5):552-556.
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