IR@PKUHSC  > 北京大学第三临床医学院  > 生殖医学中心
学科主题临床医学
Microarray evaluation of endometrial receptivity in Chinese women with polycystic ovary syndrome
Qiao, Jie; Wang, Lina; Li, Rong; Zhang, Xiaowei
关键词endometrial receptivity implantation window microarray PCOS
刊名REPRODUCTIVE BIOMEDICINE ONLINE
2008-09-01
17期:3页:425-435
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology ; Reproductive Biology
资助者Mega-projects of Science Reasearch ; Mega-projects of Science Reasearch
研究领域[WOS]Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]MATRIX METALLOPROTEINASE-26 ; UTERINE RECEPTIVITY ; EMBRYO IMPLANTATION ; MENSTRUAL-CYCLE ; EARLY-PREGNANCY ; MESSENGER-RNA ; CYTOTROPHOBLAST CELLS ; RECURRENT MISCARRIAGE ; STEROID-RECEPTORS ; TISSUE INHIBITOR
英文摘要

Patients with polycystic ovary syndrome (PCOS) have lower pregnancy and higher miscarriage rates, possibly due to decreased endometrial receptivity. In this study, endometrium was processed for RNA extraction and hybridization of chemically fragmented, biotinylated, complementary RNA on high-density oligonucleotide microarrays, and screened for 21,571 genes. Real-time polymerase chain reaction (PCR) was used to verify the result. Genes found to be down-regulated in the endometrium during the implantation window in PCOS patients included those whose activity was integral to membrane function, adhesion, invasive growth and the cytoskeleton. Among these genes, some have previously been associated with endometrial receptivity (by microarray research or other methods) and some have never previously been associated with endometrial receptivity. Using real-time PCR, expression of transmembrane 4 superfamily member 4 (TM4SF4) and matrix metalloproteinase 26 (MMP26) was found to be significantly decreased during the implantation window in patients with PCOS (P = 0.003). TM4SF4 has been demonstrated to be associated with adhesion; MMP26 has been shown to be related to degradation of extracellular matrix. It is suggested the down-regulated gene expression during the implantation window in patients with PCOS indicates differential gene expression in the endometrium between PCOS and normal women during the implantation window. This might affect endometrial receptivity.

语种英语
所属项目编号2007BAI04B04
资助者Mega-projects of Science Reasearch ; Mega-projects of Science Reasearch
WOS记录号WOS:000259031400018
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59004
专题北京大学第三临床医学院_生殖医学中心
作者单位Peking Univ, Hosp 3, Reprod Med Ctr, Beijing 100083, Peoples R China
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GB/T 7714
Qiao, Jie,Wang, Lina,Li, Rong,et al. Microarray evaluation of endometrial receptivity in Chinese women with polycystic ovary syndrome[J]. REPRODUCTIVE BIOMEDICINE ONLINE,2008,17(3):425-435.
APA Qiao, Jie,Wang, Lina,Li, Rong,&Zhang, Xiaowei.(2008).Microarray evaluation of endometrial receptivity in Chinese women with polycystic ovary syndrome.REPRODUCTIVE BIOMEDICINE ONLINE,17(3),425-435.
MLA Qiao, Jie,et al."Microarray evaluation of endometrial receptivity in Chinese women with polycystic ovary syndrome".REPRODUCTIVE BIOMEDICINE ONLINE 17.3(2008):425-435.
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