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学科主题: 临床医学
题名:
Microarray evaluation of endometrial receptivity in Chinese women with polycystic ovary syndrome
作者: Qiao, Jie; Wang, Lina; Li, Rong; Zhang, Xiaowei
关键词: endometrial receptivity ; implantation window ; microarray ; PCOS
刊名: REPRODUCTIVE BIOMEDICINE ONLINE
发表日期: 2008-09-01
卷: 17, 期:3, 页:425-435
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]: Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]: MATRIX METALLOPROTEINASE-26 ; UTERINE RECEPTIVITY ; EMBRYO IMPLANTATION ; MENSTRUAL-CYCLE ; EARLY-PREGNANCY ; MESSENGER-RNA ; CYTOTROPHOBLAST CELLS ; RECURRENT MISCARRIAGE ; STEROID-RECEPTORS ; TISSUE INHIBITOR
英文摘要:

Patients with polycystic ovary syndrome (PCOS) have lower pregnancy and higher miscarriage rates, possibly due to decreased endometrial receptivity. In this study, endometrium was processed for RNA extraction and hybridization of chemically fragmented, biotinylated, complementary RNA on high-density oligonucleotide microarrays, and screened for 21,571 genes. Real-time polymerase chain reaction (PCR) was used to verify the result. Genes found to be down-regulated in the endometrium during the implantation window in PCOS patients included those whose activity was integral to membrane function, adhesion, invasive growth and the cytoskeleton. Among these genes, some have previously been associated with endometrial receptivity (by microarray research or other methods) and some have never previously been associated with endometrial receptivity. Using real-time PCR, expression of transmembrane 4 superfamily member 4 (TM4SF4) and matrix metalloproteinase 26 (MMP26) was found to be significantly decreased during the implantation window in patients with PCOS (P = 0.003). TM4SF4 has been demonstrated to be associated with adhesion; MMP26 has been shown to be related to degradation of extracellular matrix. It is suggested the down-regulated gene expression during the implantation window in patients with PCOS indicates differential gene expression in the endometrium between PCOS and normal women during the implantation window. This might affect endometrial receptivity.

语种: 英语
所属项目编号: 2007BAI04B04
项目资助者: Mega-projects of Science Reasearch
WOS记录号: WOS:000259031400018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59004
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: Peking Univ, Hosp 3, Reprod Med Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Qiao, Jie,Wang, Lina,Li, Rong,et al. Microarray evaluation of endometrial receptivity in Chinese women with polycystic ovary syndrome[J]. REPRODUCTIVE BIOMEDICINE ONLINE,2008,17(3):425-435.
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