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学科主题口腔医学
Surface bioactivity modification of titanium by CO2 plasma treatment and induction of hydroxyapatite: In vitro and in vivo studies
Hu, Xixue2,4; Shen, Hong3; Shuai, Kegang2; Zhang, Enwei2,4; Bai, Yanjie2; Cheng, Yan2; Xiong, Xiaoling2; Wang, Shenguo3; Fang, Jing1,2,4; Wei, Shicheng1,2
关键词Titanium Surface modification Carbon dioxide plasma Hydroxyapatite Bioactivity
刊名APPLIED SURFACE SCIENCE
2011
DOI10.1016/j.apsusc.2010.08.082
257期:6页:1813-1823
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Physical ; Materials Science, Coatings & Films ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]Chemistry ; Materials Science ; Physics
关键词[WOS]BONE-LIKE APATITE ; ION-IMPLANTATION ; GROWTH-FACTOR ; POLY(LACTIDE-CO-GLYCOLIDE) ; CALCIUM ; ALLOYS ; METAL ; TI ; IMMOBILIZATION ; POLYURETHANE
英文摘要

Since metallic biomaterials used for orthopedic and dental implants possess a paucity of reactive functional groups, bioactivity modification of these materials is challenging. In the present work, the titanium discs and rods were treated with carbon dioxide plasma and then incubated in a modified simulated body fluid 1.5SBF to obtain a hydroxyapatite layer. Surface hydrophilicity of samples, changes of surface chemistry, surface morphologies of samples, and structural analysis of formed hydroxyapatite were investigated by contact angle to water, X-ray photoelectron spectrometer (XPS), scanning electron microscopy (SEM), Fourier transform infrared (FTIR) and X-ray diffraction (XRD). The results demonstrated that hydrophilicity of titanium surface was improved and hydroxyl groups increased after modification with carbon dioxide plasma treatment. The hydroxyl groups on the surface of titanium were the richest after carbon dioxide plasma treatment under the condition of 20W for less than 30 s. The hydroxyapatite formability of titanium surface was enhanced by carbon dioxide plasma pretreatment, which was attributed to the surface chemistry. MC3T3-E1 cell as a model cell was cultured on the Ti, CPT-Ti and CPT/SBF-Ti discs in vitro, and the results of the morphology and differentiation of the cell showed that CPT/SBF-Ti was the highest bioactive. The relative parameters of the new bone around the Ti and CPT/SBF-Ti rods including bone mineral density (BMD), a ratio of bone volume to total volume (BV/TV), trabecular thickness (Tb.Th.) and trabecular number (Tb.N.) were analyzed by micro-computed tomography (micro-CT) after 4-, 8- and 12-week implantation periods in vivo. The results indicated that the CPT/SBF-Ti was more advantageous for new bone formation. (C) 2010 Published by Elsevier B.V.

语种英语
WOS记录号WOS:000285408700001
引用统计
被引频次:37[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59020
专题北京大学口腔医学院
北京大学口腔医学院_图书馆
作者单位1.Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
2.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China
3.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, BNLMS, Beijing 100190, Peoples R China
4.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Hu, Xixue,Shen, Hong,Shuai, Kegang,et al. Surface bioactivity modification of titanium by CO2 plasma treatment and induction of hydroxyapatite: In vitro and in vivo studies[J]. APPLIED SURFACE SCIENCE,2011,257(6):1813-1823.
APA Hu, Xixue.,Shen, Hong.,Shuai, Kegang.,Zhang, Enwei.,Bai, Yanjie.,...&Wei, Shicheng.(2011).Surface bioactivity modification of titanium by CO2 plasma treatment and induction of hydroxyapatite: In vitro and in vivo studies.APPLIED SURFACE SCIENCE,257(6),1813-1823.
MLA Hu, Xixue,et al."Surface bioactivity modification of titanium by CO2 plasma treatment and induction of hydroxyapatite: In vitro and in vivo studies".APPLIED SURFACE SCIENCE 257.6(2011):1813-1823.
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