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学科主题: 口腔医学
题名:
Surface bioactivity modification of titanium by CO2 plasma treatment and induction of hydroxyapatite: In vitro and in vivo studies
作者: Hu, Xixue2,4; Shen, Hong3; Shuai, Kegang2; Zhang, Enwei2,4; Bai, Yanjie2; Cheng, Yan2; Xiong, Xiaoling2; Wang, Shenguo3; Fang, Jing1,2,4; Wei, Shicheng1,2
关键词: Titanium ; Surface modification ; Carbon dioxide plasma ; Hydroxyapatite ; Bioactivity
刊名: APPLIED SURFACE SCIENCE
发表日期: 2011
DOI: 10.1016/j.apsusc.2010.08.082
卷: 257, 期:6, 页:1813-1823
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Physical ; Materials Science, Coatings & Films ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]: Chemistry ; Materials Science ; Physics
关键词[WOS]: BONE-LIKE APATITE ; ION-IMPLANTATION ; GROWTH-FACTOR ; POLY(LACTIDE-CO-GLYCOLIDE) ; CALCIUM ; ALLOYS ; METAL ; TI ; IMMOBILIZATION ; POLYURETHANE
英文摘要:

Since metallic biomaterials used for orthopedic and dental implants possess a paucity of reactive functional groups, bioactivity modification of these materials is challenging. In the present work, the titanium discs and rods were treated with carbon dioxide plasma and then incubated in a modified simulated body fluid 1.5SBF to obtain a hydroxyapatite layer. Surface hydrophilicity of samples, changes of surface chemistry, surface morphologies of samples, and structural analysis of formed hydroxyapatite were investigated by contact angle to water, X-ray photoelectron spectrometer (XPS), scanning electron microscopy (SEM), Fourier transform infrared (FTIR) and X-ray diffraction (XRD). The results demonstrated that hydrophilicity of titanium surface was improved and hydroxyl groups increased after modification with carbon dioxide plasma treatment. The hydroxyl groups on the surface of titanium were the richest after carbon dioxide plasma treatment under the condition of 20W for less than 30 s. The hydroxyapatite formability of titanium surface was enhanced by carbon dioxide plasma pretreatment, which was attributed to the surface chemistry. MC3T3-E1 cell as a model cell was cultured on the Ti, CPT-Ti and CPT/SBF-Ti discs in vitro, and the results of the morphology and differentiation of the cell showed that CPT/SBF-Ti was the highest bioactive. The relative parameters of the new bone around the Ti and CPT/SBF-Ti rods including bone mineral density (BMD), a ratio of bone volume to total volume (BV/TV), trabecular thickness (Tb.Th.) and trabecular number (Tb.N.) were analyzed by micro-computed tomography (micro-CT) after 4-, 8- and 12-week implantation periods in vivo. The results indicated that the CPT/SBF-Ti was more advantageous for new bone formation. (C) 2010 Published by Elsevier B.V.

语种: 英语
所属项目编号: 2007CB936103 ; PKUJC2009001 ; 20090450242 ; 985
项目资助者: State Key Development Program for Basic Research of China ; Peking University Interdisciplinary and Emerging Disciplines Research Foundation ; China Postdoctoral Science Foundation ; Peking University
WOS记录号: WOS:000285408700001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59020
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
2.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China
3.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, BNLMS, Beijing 100190, Peoples R China
4.Peking Univ, Coll Engn, Beijing 100871, Peoples R China

Recommended Citation:
Hu, Xixue,Shen, Hong,Shuai, Kegang,et al. Surface bioactivity modification of titanium by CO2 plasma treatment and induction of hydroxyapatite: In vitro and in vivo studies[J]. APPLIED SURFACE SCIENCE,2011,257(6):1813-1823.
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