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学科主题: 基础医学
题名:
An alternative splice form of CMTM8 induces apoptosis
作者: Li, Dan; Jin, Caining; Yin, Caihua; Zhang, Yingmei; Pang, Bo; Tian, Linjie; Han, Wenfing; Ma, Dalong; Wang, Ying
关键词: chemokine-like factor (CKLF)-like MARVEL transmembrane domain containing 8-v2 ; Chemokine-like factor (CKLF)-like MARVEL transmembrane domain containing 8 ; programmed cell death
刊名: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
发表日期: 2007
DOI: 10.1016/j.biocel.2007.06.002
卷: 39, 期:11, 页:2107-2119
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]: CYTOCHROME-C ; CELL-DEATH ; CLONING ; COMPLEX ; DATP
英文摘要:

Previous studies have demonstrated that the chemokine-like factor (CKLF)-like MARVEL transmembrane domain containing 8 (CMTM8) protein accelerates the ligand-induced clearance of epidermal growth factor receptor (EGFR) from the cell surface. The absence of EGFR-mediated signaling induces cells to undergo apoptosis via caspase-dependent and -independent pathways. Here we report the cloning and sequencing of an alternative splice form of CMTM8, obtained from a human blood cDNA library, that utilizes apoptotic pathways distinct from CMTM8. The alternative splice variant arises from a deletion of exon 2 that prevents the expression of a full-length MARVEL domain, and cytosolic YXX Phi motifs. Nevertheless, CMTM8-v2 maintains the ability to induce apoptosis via caspase-dependent and -independent pathways to inhibit cell growth and colony formation. CMTM8 and CMTM8-v2 display different expression profiles and distinct subcellular localization patterns, while operating via different mechanisms to induce apoptosis. CMTM8-v2 did not affect EGFR internalization, implying that the MARVEL domain and/or the cytosolic YXX Phi motifs are necessary for CMTM8 to accelerate ligand-induced EGFR internalization. (C) 2007 Published by Elsevier Ltd.

语种: 英语
WOS记录号: WOS:000250183200012
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59022
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Lab Med Immunol, Beijing 100083, Peoples R China
2.Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China

Recommended Citation:
Li, Dan,Jin, Caining,Yin, Caihua,et al. An alternative splice form of CMTM8 induces apoptosis[J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY,2007,39(11):2107-2119.
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