IR@PKUHSC  > 北京大学基础医学院  > 免疫学系
学科主题基础医学
An alternative splice form of CMTM8 induces apoptosis
Li, Dan; Jin, Caining; Yin, Caihua; Zhang, Yingmei; Pang, Bo; Tian, Linjie; Han, Wenfing; Ma, Dalong; Wang, Ying
关键词chemokine-like factor (CKLF)-like MARVEL transmembrane domain containing 8-v2 Chemokine-like factor (CKLF)-like MARVEL transmembrane domain containing 8 programmed cell death
刊名INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
2007
DOI10.1016/j.biocel.2007.06.002
39期:11页:2107-2119
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]CYTOCHROME-C ; CELL-DEATH ; CLONING ; COMPLEX ; DATP
英文摘要

Previous studies have demonstrated that the chemokine-like factor (CKLF)-like MARVEL transmembrane domain containing 8 (CMTM8) protein accelerates the ligand-induced clearance of epidermal growth factor receptor (EGFR) from the cell surface. The absence of EGFR-mediated signaling induces cells to undergo apoptosis via caspase-dependent and -independent pathways. Here we report the cloning and sequencing of an alternative splice form of CMTM8, obtained from a human blood cDNA library, that utilizes apoptotic pathways distinct from CMTM8. The alternative splice variant arises from a deletion of exon 2 that prevents the expression of a full-length MARVEL domain, and cytosolic YXX Phi motifs. Nevertheless, CMTM8-v2 maintains the ability to induce apoptosis via caspase-dependent and -independent pathways to inhibit cell growth and colony formation. CMTM8 and CMTM8-v2 display different expression profiles and distinct subcellular localization patterns, while operating via different mechanisms to induce apoptosis. CMTM8-v2 did not affect EGFR internalization, implying that the MARVEL domain and/or the cytosolic YXX Phi motifs are necessary for CMTM8 to accelerate ligand-induced EGFR internalization. (C) 2007 Published by Elsevier Ltd.

语种英语
WOS记录号WOS:000250183200012
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59022
Collection北京大学基础医学院_免疫学系
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Lab Med Immunol, Beijing 100083, Peoples R China
2.Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Li, Dan,Jin, Caining,Yin, Caihua,et al. An alternative splice form of CMTM8 induces apoptosis[J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY,2007,39(11):2107-2119.
APA Li, Dan.,Jin, Caining.,Yin, Caihua.,Zhang, Yingmei.,Pang, Bo.,...&Wang, Ying.(2007).An alternative splice form of CMTM8 induces apoptosis.INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY,39(11),2107-2119.
MLA Li, Dan,et al."An alternative splice form of CMTM8 induces apoptosis".INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 39.11(2007):2107-2119.
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