IR@PKUHSC  > 北京大学基础医学院  > 神经生物学系
学科主题基础医学
Mothers of Autistic Children: Lower Plasma Levels of Oxytocin and Arg-Vasopressin and a Higher Level of Testosterone
Xu, Xin-Jie1,2,3; Shou, Xiao-Jing1,2,3; Li, Jin1,2,3; Jia, Mei-Xiang4; Zhang, Ji-Shui5,6; Guo, Yan7; Wei, Qing-Yun8; Zhang, Xiu-Ting9; Han, Song-Ping10; Zhang, Rong1,2,3; Han, Ji-Sheng1,2,3
刊名PLOS ONE
2013-09-25
DOI10.1371/journal.pone.0074849
8期:9
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]ARGININE-VASOPRESSIN ; SPECTRUM DISORDER ; SOCIAL-BEHAVIOR ; GENES ; BRAIN ; MECHANISMS ; PHENOTYPE ; PARENTS ; BROADER ; WOMEN
英文摘要

Background: Autism is a pervasive neurodevelopmental disorder, thought to be caused by a combination of genetic heritability and environmental risk factors. Some autistic-like traits have been reported in mothers of autistic children. We hypothesized that dysregulation of oxytocin (OXT), Arg-vasopressin (AVP) and sex hormones, found in autistic children, may also exist in their mothers.

Methods: We determined plasma levels of OXT (40 in autism vs. 26 in control group), AVP (40 vs. 17) and sex hormones (61 vs. 47) in mothers of autistic and normal children by enzyme immunoassay and radioimmunoassay, respectively and investigated their relationships with the children′s autistic behavior scores (Childhood Autism Rating Scale (CARS) and Autism Behavior Checklist (ABC)).

Results: Significantly lower plasma concentrations of OXT (p<0.001) and AVP (p<0.001), as well as a higher level of plasma testosterone (p<0.05), were found in mothers of autistic children vs. those of control. The children′s autistic behavior scores were negatively associated with maternal plasma levels of OXT and AVP.

Conclusions: These results suggest that dysregulation of OXT, AVP and/or testosterone systems exist in mothers of autistic children, which may impact children′s susceptibility to autism.

语种英语
WOS记录号WOS:000325218700043
项目编号81271507
资助机构National Natural Science Foundation of China ; Peking University
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59024
专题北京大学基础医学院_神经生物学系
北京大学基础医学院
北京大学第一临床医学院_输血科
作者单位1.Beijing Tongkang Rehabil Ctr, Beijing, Peoples R China
2.HANS Int Inc, Belle Mead, NJ USA
3.Peking Univ, Mental Hlth Inst, Beijing 100871, Peoples R China
4.Beijing Yangguang Youyi Rehabil Ctr, Beijing, Peoples R China
5.Peking Univ, Neurosci Res Inst, Sch Basic Med Sci, Beijing 100871, Peoples R China
6.Peking Univ, Dept Neurobiol, Sch Basic Med Sci, Beijing 100871, Peoples R China
7.Peking Univ, Minist Educ, Key Lab Neurosci, Natl Hlth & Family Planning Commiss, Beijing 100871, Peoples R China
8.Capital Univ Med Sci, Beijing Childrens Hosp, Dept Neurol, Beijing, Peoples R China
9.Capital Univ Med Sci, Beijing Childrens Hosp, Ctr Rehabil, Beijing, Peoples R China
10.Beijing Univ Chinese Med, Dept Ophthalmol, Affiliated Hosp 3, Beijing, Peoples R China
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GB/T 7714
Xu, Xin-Jie,Shou, Xiao-Jing,Li, Jin,et al. Mothers of Autistic Children: Lower Plasma Levels of Oxytocin and Arg-Vasopressin and a Higher Level of Testosterone[J]. PLOS ONE,2013,8(9).
APA Xu, Xin-Jie.,Shou, Xiao-Jing.,Li, Jin.,Jia, Mei-Xiang.,Zhang, Ji-Shui.,...&Han, Ji-Sheng.(2013).Mothers of Autistic Children: Lower Plasma Levels of Oxytocin and Arg-Vasopressin and a Higher Level of Testosterone.PLOS ONE,8(9).
MLA Xu, Xin-Jie,et al."Mothers of Autistic Children: Lower Plasma Levels of Oxytocin and Arg-Vasopressin and a Higher Level of Testosterone".PLOS ONE 8.9(2013).
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