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学科主题: 基础医学
题名:
Mothers of Autistic Children: Lower Plasma Levels of Oxytocin and Arg-Vasopressin and a Higher Level of Testosterone
作者: Xu, Xin-Jie1,2,3; Shou, Xiao-Jing1,2,3; Li, Jin1,2,3; Jia, Mei-Xiang4; Zhang, Ji-Shui5,6; Guo, Yan7; Wei, Qing-Yun8; Zhang, Xiu-Ting9; Han, Song-Ping10; Zhang, Rong1,2,3; Han, Ji-Sheng1,2,3
刊名: PLOS ONE
发表日期: 2013-09-25
DOI: 10.1371/journal.pone.0074849
卷: 8, 期:9
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: ARGININE-VASOPRESSIN ; SPECTRUM DISORDER ; SOCIAL-BEHAVIOR ; GENES ; BRAIN ; MECHANISMS ; PHENOTYPE ; PARENTS ; BROADER ; WOMEN
英文摘要:

Background: Autism is a pervasive neurodevelopmental disorder, thought to be caused by a combination of genetic heritability and environmental risk factors. Some autistic-like traits have been reported in mothers of autistic children. We hypothesized that dysregulation of oxytocin (OXT), Arg-vasopressin (AVP) and sex hormones, found in autistic children, may also exist in their mothers.

Methods: We determined plasma levels of OXT (40 in autism vs. 26 in control group), AVP (40 vs. 17) and sex hormones (61 vs. 47) in mothers of autistic and normal children by enzyme immunoassay and radioimmunoassay, respectively and investigated their relationships with the children′s autistic behavior scores (Childhood Autism Rating Scale (CARS) and Autism Behavior Checklist (ABC)).

Results: Significantly lower plasma concentrations of OXT (p<0.001) and AVP (p<0.001), as well as a higher level of plasma testosterone (p<0.05), were found in mothers of autistic children vs. those of control. The children′s autistic behavior scores were negatively associated with maternal plasma levels of OXT and AVP.

Conclusions: These results suggest that dysregulation of OXT, AVP and/or testosterone systems exist in mothers of autistic children, which may impact children′s susceptibility to autism.

语种: 英语
所属项目编号: 81271507
项目资助者: National Natural Science Foundation of China ; Peking University
WOS记录号: WOS:000325218700043
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59024
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Beijing Tongkang Rehabil Ctr, Beijing, Peoples R China
2.HANS Int Inc, Belle Mead, NJ USA
3.Peking Univ, Mental Hlth Inst, Beijing 100871, Peoples R China
4.Beijing Yangguang Youyi Rehabil Ctr, Beijing, Peoples R China
5.Peking Univ, Neurosci Res Inst, Sch Basic Med Sci, Beijing 100871, Peoples R China
6.Peking Univ, Dept Neurobiol, Sch Basic Med Sci, Beijing 100871, Peoples R China
7.Peking Univ, Minist Educ, Key Lab Neurosci, Natl Hlth & Family Planning Commiss, Beijing 100871, Peoples R China
8.Capital Univ Med Sci, Beijing Childrens Hosp, Dept Neurol, Beijing, Peoples R China
9.Capital Univ Med Sci, Beijing Childrens Hosp, Ctr Rehabil, Beijing, Peoples R China
10.Beijing Univ Chinese Med, Dept Ophthalmol, Affiliated Hosp 3, Beijing, Peoples R China

Recommended Citation:
Xu, Xin-Jie,Shou, Xiao-Jing,Li, Jin,et al. Mothers of Autistic Children: Lower Plasma Levels of Oxytocin and Arg-Vasopressin and a Higher Level of Testosterone[J]. PLOS ONE,2013,8(9).
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