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学科主题: 基础医学
题名:
Neurotrophic and neuroprotective effects of tripchlorolide, an extract of Chinese herb Tripterygium wilfordii Hook F, on dopaminergic neurons
作者: Li, FQ; Cheng, XX; Liang, XB; Wang, XH; Xue, B; He, QH; Wang, XM; Han, JS
关键词: tripchlorolide ; Tripterygium wilfordii ; Hook F ; immunosuppressant ; Chinese herb ; neurotrophic ; brain-derived neurotrophic factor ; Parkinson&prime ; s disease
刊名: EXPERIMENTAL NEUROLOGY
发表日期: 2003
DOI: 10.1006/exnr.2002.8049
卷: 179, 期:1, 页:28-37
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: MEDIAL FOREBRAIN-BUNDLE ; NECROSIS-FACTOR-ALPHA ; NERVE GROWTH-FACTOR ; SUBSTANTIA-NIGRA ; PARKINSONIAN-PATIENTS ; IMMUNOPHILIN LIGANDS ; PROMOTE SURVIVAL ; MESSENGER-RNA ; BRAIN ; TRANSECTION
英文摘要:

It has been reported recently that the immunosuppressant FK506 produced neurotrophic and neuroprotective effects on dopaminergic neurons in vitro and in vivo. We investigated whether tripchlorolide, an immunosuppressive extract of Chinese herb Tripterygium wilfordii Hook F, could exert similar neurotrophic and neuroprotective effects similar to those of FK506. It was found that tripchlorolide promoted axonal elongation and protected dopaminergic neurons from a neurotoxic lesion induced by 1-methyl-4-phenylpyridinium ion (MPP+) at concentrations of as low as 10(-12) to 10(-8) M. In situ hybridization study revealed that tripchlorolide stimulated brain-derived neurotrophic factor (BDNF) mRNA expression. In vivo administration of tripchlorolide (1 mug/kg, ip) for 28 days effectively attenuated the rotational behavior challenged by D-amphetamine in the model rats by transection of the medial forebrain bundle. In addition, tripchlorolide treatment (0.5 or 1 mug/kg/day for 28 days) increased the survival of dopaminergic neurons in substantia nigra pars compacta by 50 and 67%, respectively. Moreover, tripchlorolide markedly prevented the decrease in amount of dopamine in the striatum of model rats. Taken together, our data provide the first evidence that tripchlorolide acts as a neuroprotective molecule that rescues MPP+ or axotomy-induced degeneration of dopaminergic neurons, which may imply its therapeutic potential for Parkinson′s disease. The underlying mechanism may be relevant to its neurotrophic effect and its efficacy in stimulating the expression of BDNF. (C) 2002 Elsevier Science (USA).

语种: 英语
WOS记录号: WOS:000180355100005
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59025
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China

Recommended Citation:
Li, FQ,Cheng, XX,Liang, XB,et al. Neurotrophic and neuroprotective effects of tripchlorolide, an extract of Chinese herb Tripterygium wilfordii Hook F, on dopaminergic neurons[J]. EXPERIMENTAL NEUROLOGY,2003,179(1):28-37.
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