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学科主题: 临床医学
题名:
Electro-acupuncture protects against hypoxic-ischemic brain-damaged immature rat via hydrogen sulfide as a possible mediator
作者: Liu, Ying1; Zou, Li-Ping1; Du, Jun-Bao2; Wong, Virginia3
关键词: Electro-acupuncture ; Hypoxic-ischemic brain-damage ; Hydrogen sulfide ; Cystathionine-beta-synthase
刊名: NEUROSCIENCE LETTERS
发表日期: 2010-11-12
DOI: 10.1016/j.neulet.2010.08.068
卷: 485, 期:1, 页:74-78
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CEREBRAL-PALSY ; ACUPUNCTURE ; INVOLVEMENT ; CYSTEINE ; CHANNEL ; STROKE ; TRIAL ; H2S
英文摘要:

We investigated whether hydrogen sulfide (H(2)S) may be a mediator of electro-acupuncture (EA) stimulation treatment for hypoxic-ischemic brain-damage (HIBD). We studied a HIBD 7-day-old rat model with 4 types of treatments: (1) 14 sessions of EA; (2) hydroxylamine (HA), an inhibitor of cystathionine-beta-synthase (CBS), the key enzyme of H(2)S generation; (3) both EA and HA; or (4) no treatment. Sham-treated rats with or without EA were also studied. Regional cerebral blood flow (rCBF) was monitored before, during and after EA at different periods of treatment (d1, 7 and 14 sessions). We evaluated motor function, H2S levels and CBS expression in the cerebral cortex and prepared cerebral pathomorphological images after 14 sessions of treatment. EA stimulation could increase local blood circulation and improve motor function in HIBD rats. HIBD significantly increased H(2)S levels of brain tissue as compared with sham treatment, and EA treatment could decrease the H(2)S generation. Rats with HIBD receiving both EA and HA therapy showed greatly recovered motor function and brain morphology. H(2)S might be a mediator of EA treatment of HIBD in rats. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 2007G05
项目资助者: International Cooperation of Science and Technique Foundation of Beijing
WOS记录号: WOS:000283266700015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59031
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Chinese Peoples Liberat Army Gen Hosp, Dept Pediat, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat, Beijing 100871, Peoples R China
3.Univ Hong Kong, Dept Paediat & Adolescent Med, Div Neurodev Paediat, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Liu, Ying,Zou, Li-Ping,Du, Jun-Bao,et al. Electro-acupuncture protects against hypoxic-ischemic brain-damaged immature rat via hydrogen sulfide as a possible mediator[J]. NEUROSCIENCE LETTERS,2010,485(1):74-78.
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