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Electro-acupuncture protects against hypoxic-ischemic brain-damaged immature rat via hydrogen sulfide as a possible mediator
Liu, Ying1; Zou, Li-Ping1; Du, Jun-Bao2; Wong, Virginia3
关键词Electro-acupuncture Hypoxic-ischemic brain-damage Hydrogen sulfide Cystathionine-beta-synthase
刊名NEUROSCIENCE LETTERS
2010-11-12
DOI10.1016/j.neulet.2010.08.068
485期:1页:74-78
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]CEREBRAL-PALSY ; ACUPUNCTURE ; INVOLVEMENT ; CYSTEINE ; CHANNEL ; STROKE ; TRIAL ; H2S
英文摘要

We investigated whether hydrogen sulfide (H(2)S) may be a mediator of electro-acupuncture (EA) stimulation treatment for hypoxic-ischemic brain-damage (HIBD). We studied a HIBD 7-day-old rat model with 4 types of treatments: (1) 14 sessions of EA; (2) hydroxylamine (HA), an inhibitor of cystathionine-beta-synthase (CBS), the key enzyme of H(2)S generation; (3) both EA and HA; or (4) no treatment. Sham-treated rats with or without EA were also studied. Regional cerebral blood flow (rCBF) was monitored before, during and after EA at different periods of treatment (d1, 7 and 14 sessions). We evaluated motor function, H2S levels and CBS expression in the cerebral cortex and prepared cerebral pathomorphological images after 14 sessions of treatment. EA stimulation could increase local blood circulation and improve motor function in HIBD rats. HIBD significantly increased H(2)S levels of brain tissue as compared with sham treatment, and EA treatment could decrease the H(2)S generation. Rats with HIBD receiving both EA and HA therapy showed greatly recovered motor function and brain morphology. H(2)S might be a mediator of EA treatment of HIBD in rats. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000283266700015
项目编号2007G05
资助机构International Cooperation of Science and Technique Foundation of Beijing
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59031
专题北京大学第一临床医学院_儿科
作者单位1.Chinese Peoples Liberat Army Gen Hosp, Dept Pediat, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat, Beijing 100871, Peoples R China
3.Univ Hong Kong, Dept Paediat & Adolescent Med, Div Neurodev Paediat, Hong Kong, Hong Kong, Peoples R China
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GB/T 7714
Liu, Ying,Zou, Li-Ping,Du, Jun-Bao,et al. Electro-acupuncture protects against hypoxic-ischemic brain-damaged immature rat via hydrogen sulfide as a possible mediator[J]. NEUROSCIENCE LETTERS,2010,485(1):74-78.
APA Liu, Ying,Zou, Li-Ping,Du, Jun-Bao,&Wong, Virginia.(2010).Electro-acupuncture protects against hypoxic-ischemic brain-damaged immature rat via hydrogen sulfide as a possible mediator.NEUROSCIENCE LETTERS,485(1),74-78.
MLA Liu, Ying,et al."Electro-acupuncture protects against hypoxic-ischemic brain-damaged immature rat via hydrogen sulfide as a possible mediator".NEUROSCIENCE LETTERS 485.1(2010):74-78.
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