IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
alpha-Fetoprotein shields hepatocellular carcinoma cells from apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand
Li, Mengsen; Zhou, Sheng; Liu, Xinhua; Li, Pingfeng; McNutt, Michael A.; Li, Gang
关键词alpha-fetoprotein tumor necrosis factor-related apoptosis-inducing ligand apoptosis caspase-3
刊名CANCER LETTERS
2007-05-08
DOI10.1016/j.canlet.2006.09.004
249期:2页:227-234
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]TRAIL-INDUCED APOPTOSIS ; CHEMOTHERAPEUTIC-AGENTS ; PROTEIN EXPRESSION ; IN-VIVO ; CANCER ; DEATH ; GROWTH ; SENSITIZATION ; RESISTANCE ; ACTIVATION
英文摘要

The interference of alpha-fetoprotein (AFP) with the apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in Bel 7402 cells was investigated in the current study. The results showed a moderate degree of drug-resistance of Bel 7402 cells to TRAIL. The caspase-3 cascade was the main pathway involved in TRAIL-induced apoptosis, which was virtually abolished in the presence of AFP. TRAIL together with antibody against AFP was able to accelerate the death of tumor cells. This study suggests the possibility a therapeutic strategy for improving clinical treatment of liver tumor with TRAIL could be effected through antagonizing the shelter effect of AFP. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000246088900012
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59032
专题北京大学基础医学院_病理学系
作者单位1.Hainan Med Coll, Lab Anal Chem, Hainan 571101, Peoples R China
2.Peking Univ, Ctr Infect Dis, Beijing 100083, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Beijing 100083, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100083, Peoples R China
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GB/T 7714
Li, Mengsen,Zhou, Sheng,Liu, Xinhua,et al. alpha-Fetoprotein shields hepatocellular carcinoma cells from apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand[J]. CANCER LETTERS,2007,249(2):227-234.
APA Li, Mengsen,Zhou, Sheng,Liu, Xinhua,Li, Pingfeng,McNutt, Michael A.,&Li, Gang.(2007).alpha-Fetoprotein shields hepatocellular carcinoma cells from apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand.CANCER LETTERS,249(2),227-234.
MLA Li, Mengsen,et al."alpha-Fetoprotein shields hepatocellular carcinoma cells from apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand".CANCER LETTERS 249.2(2007):227-234.
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