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学科主题: 临床医学
题名:
Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy
作者: Gu, Q.; Xia, H. H. X.; Wang, J. D.; Wong, W. M.; Chan, A. O. O.; Lai, K. C.; Chan, C. K.; Yuen, M. F.; Fung, F. M. Y.; Wong, K. W.; Lam, Sx.; Wong, B. C. Y.
关键词: Helicobacter pylori ; clarithromycin ; antibiotic resistance ; H. pylori eradication
刊名: DIGESTION
发表日期: 2006
DOI: 10.1159/000094040
卷: 73, 期:2-3, 页:101-106
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: ERADICATION RATES ; ANTIMICROBIAL RESISTANCE ; HIGH PREVALENCE ; DUODENAL-ULCER ; UNITED-STATES ; RABEPRAZOLE ; INFECTION ; METRONIDAZOLE ; OMEPRAZOLE ; AMOXICILLIN
英文摘要:

Aim: To determine the antibiotic susceptibility of Helicobacter pylori and evaluate the efficacy of a clarithromycin-based triple therapy in relation to antibiotic resistance. Methods: Consecutive patients referred for upper endoscopy due to dyspeptic symptoms were recruited. Gastric biopsies were obtained for the CLO test, histology and culture. Antibiotic susceptibility was assessed by the E-test. Patients with H. pylori infection received rabeprazole 20 mg, clarithromycin 500 mg, and anoxicillin 1,000 mg, all twice daily for 7 days. Results: of 234 patients recruited, 124 were H. pylori-positive and culture was successful in 102 patients. The updated prevalences of resistance to clarithromycin, amoxicillin and metronidazole were 7.8, 0 and 39.2%, respectively. A total of 86 patients received 1-week triple therapy with rabeprazole 20 mg, clarithromycin 500 mg, and amoxicillin 1,000 mg, all twice daily, and 81 patients attended the follow-up test. Eradication rates by per-protocol and intention-to-treat analysis were 92.6 and 87.2%, respectively. The eradication rate by per protocol was significantly higher in patients with clarithromycin-susceptible strains than in those with clarithromycin-resistant strains (98.6 vs. 28.6%, p < 0.001). Conclusion: Clarithromycin resistance reduces the clinical efficacy of clarithromycin-based triple therapy. However, due to the low prevalence of clarithromycin resistance, clarithromycin-based therapy is still the first choice for clinical use. Copyright (c) 2006 S. Karger AG, Basel.

语种: 英语
WOS记录号: WOS:000239427800005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59035
Appears in Collections:北京大学第一临床医学院_消化内科_期刊论文

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作者单位: 1.Univ Hong Kong, Dept Med, Hong Kong, Peoples R China
2.Peking Univ, Hosp 1, Dept Gastroenterol, Beijing 100871, Peoples R China

Recommended Citation:
Gu, Q.,Xia, H. H. X.,Wang, J. D.,et al. Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy[J]. DIGESTION,2006,73(2-3):101-106.
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