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Current status of haploidentical stem cell transplantation for leukemia
Huang, Xiao-jun
刊名JOURNAL OF HEMATOLOGY & ONCOLOGY
2008-12-31
DOI10.1186/1756-8722-1-27
1
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Oncology ; Hematology
资助者National Outstanding Young Scientist&prime ; s Foundation of China ; New Century Excellent Talents in University ; Innovative Research Team in University ; National Outstanding Young Scientist&prime ; s Foundation of China ; New Century Excellent Talents in University ; Innovative Research Team in University
研究领域[WOS]Oncology ; Hematology
关键词[WOS]VERSUS-HOST-DISEASE ; BONE-MARROW-TRANSPLANTATION ; DONOR LYMPHOCYTE INFUSIONS ; COLONY-STIMULATING FACTOR ; BLOOD PROGENITOR CELLS ; RISK ACUTE-LEUKEMIA ; REGULATORY T-CELLS ; PERIPHERAL-BLOOD ; UNRELATED DONORS ; HEMATOLOGICAL MALIGNANCIES
英文摘要

Haploidentical hematopoietic stem cell transplantation has made tremendous progress over the past 20 years and has become a feasible option for leukemia patients without a HLA identical sibling donor. The early complications of severe graft-versus-host disease (GVHD), graft failure and delayed engraftment, as well as disease recurrence have limited the use of this approach. Newer strategies have been applied and overcome some of the problems, including the use of T-cell depleted graft, "mega" dose of stem cells, intensive post-transplant immunosuppression and manipulation of the graft. These have decreased the transplant related mortality and GVHD associated with haploidentical transplantation, however, the major problems of disease relapse and infection, which related to late immune reconstitution, limit the development of haploidentical HSCT. Future challenges remain in improving post-transplant immune reconstitution and finding the best approach to reduce the incidence and severity of GVHD, while preserving graft-versus-leukemia effect to prevent the recurrence of underlying malignancy.

语种英语
所属项目编号30725038 ; NECT-04-0011 ; IRT0702
资助者National Outstanding Young Scientist&prime ; s Foundation of China ; New Century Excellent Talents in University ; Innovative Research Team in University ; National Outstanding Young Scientist&prime ; s Foundation of China ; New Century Excellent Talents in University ; Innovative Research Team in University
WOS记录号WOS:000272011300001
引用统计
被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59039
专题北京大学第二临床医学院_血液科
作者单位Peking Univ, Inst Hematol, Peoples Hosp, Beijing 10044, Peoples R China
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GB/T 7714
Huang, Xiao-jun. Current status of haploidentical stem cell transplantation for leukemia[J]. JOURNAL OF HEMATOLOGY & ONCOLOGY,2008,1.
APA Huang, Xiao-jun.(2008).Current status of haploidentical stem cell transplantation for leukemia.JOURNAL OF HEMATOLOGY & ONCOLOGY,1.
MLA Huang, Xiao-jun."Current status of haploidentical stem cell transplantation for leukemia".JOURNAL OF HEMATOLOGY & ONCOLOGY 1(2008).
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