北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 血液科  > 期刊论文
学科主题: 临床医学
题名:
Current status of haploidentical stem cell transplantation for leukemia
作者: Huang, Xiao-jun
刊名: JOURNAL OF HEMATOLOGY & ONCOLOGY
发表日期: 2008-12-31
DOI: 10.1186/1756-8722-1-27
卷: 1
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Hematology
研究领域[WOS]: Oncology ; Hematology
关键词[WOS]: VERSUS-HOST-DISEASE ; BONE-MARROW-TRANSPLANTATION ; DONOR LYMPHOCYTE INFUSIONS ; COLONY-STIMULATING FACTOR ; BLOOD PROGENITOR CELLS ; RISK ACUTE-LEUKEMIA ; REGULATORY T-CELLS ; PERIPHERAL-BLOOD ; UNRELATED DONORS ; HEMATOLOGICAL MALIGNANCIES
英文摘要:

Haploidentical hematopoietic stem cell transplantation has made tremendous progress over the past 20 years and has become a feasible option for leukemia patients without a HLA identical sibling donor. The early complications of severe graft-versus-host disease (GVHD), graft failure and delayed engraftment, as well as disease recurrence have limited the use of this approach. Newer strategies have been applied and overcome some of the problems, including the use of T-cell depleted graft, "mega" dose of stem cells, intensive post-transplant immunosuppression and manipulation of the graft. These have decreased the transplant related mortality and GVHD associated with haploidentical transplantation, however, the major problems of disease relapse and infection, which related to late immune reconstitution, limit the development of haploidentical HSCT. Future challenges remain in improving post-transplant immune reconstitution and finding the best approach to reduce the incidence and severity of GVHD, while preserving graft-versus-leukemia effect to prevent the recurrence of underlying malignancy.

语种: 英语
所属项目编号: 30725038 ; NECT-04-0011 ; IRT0702
项目资助者: National Outstanding Young Scientist&prime ; s Foundation of China ; New Century Excellent Talents in University ; Innovative Research Team in University
WOS记录号: WOS:000272011300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59039
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Inst Hematol, Peoples Hosp, Beijing 10044, Peoples R China

Recommended Citation:
Huang, Xiao-jun. Current status of haploidentical stem cell transplantation for leukemia[J]. JOURNAL OF HEMATOLOGY & ONCOLOGY,2008,1.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Huang, Xiao-jun]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Huang, Xiao-jun]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace