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学科主题: 药学
题名:
Application of functional vincristine plus dasatinib liposomes to deletion of vasculogenic mimicry channels in triple-negative breast cancer
作者: Zeng, Fan; Ju, Rui-Jun; Liu, Lei; Xie, Hong-Jun; Mu, Li-Min; Zhao, Yao; Yan, Yan; Hu, Ying-Jie; Wu, Jia-Shuan; Lu, Wan-Liang
关键词: functional liposome ; vincristine ; dasatinib ; vasculogenic mimicry channel ; triple-negative breast cancer
刊名: ONCOTARGET
发表日期: 2015-11-03
卷: 6, 期:34, 页:36625-36642
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Cell Biology
研究领域[WOS]: Oncology ; Cell Biology
关键词[WOS]: SQUAMOUS-CELL CARCINOMAS ; ANTITUMOR-ACTIVITY ; CD133(+) CELLS ; APOPTOSIS ; SRC ; LEUKEMIA ; PATHWAYS ; SURVIVAL ; PEPTIDE ; KINASE
英文摘要:

Standard chemotherapy cannot eradicate triple-negative breast cancer (TNBC) while the residual cancer cells readily form the vasculogenic mimicry (VM) channels, which lead to the relapse of cancer after treatment. In this study, the functional vincristine plus dasatinib liposomes, modified by a targeting molecule DSPE-PEG(2000)-c(RGDyK), were fabricated to address this issue. The investigations were performed on TNBC MDA-MB-231 cells and MDA-MB-231 xenografts in nude mice. The liposomes exhibited the superior performances in the following aspects: the enhancement of cellular uptake via targeted action; the induction of apoptosis via activation of caspase 8, 9, and 3, increased expression of Bax, decreased expression of Mcl-1, and generation of reactive oxygen species (ROS); and the deletion of VM channels via inhibitions on the VM channel indicators, which consisted of vascular endothelial-cadherin (VE-Cad), focal adhesion kinase (FAK), phosphatidylinositide 3-kinase (PI3K), and matrix metallopeptidases (MMP-2, and MMP-9). Furthermore, the liposomes displayed the prolonged circulation time in the blood, the increased accumulation in tumor tissue, and the improved therapeutic efficacy along with deletion of VM channels in the TNBC-bearing mice. In conclusion, the nanostructured functional drug-loaded liposomes may provide a promising strategy for the treatment of invasive TNBC along with deletion of VM channels.

语种: 英语
所属项目编号: 81373343 ; 7131009
项目资助者: National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000366111900119
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59044
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Beijing Key Lab Mol Pharmaceut & New Drug Syst, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Zeng, Fan,Ju, Rui-Jun,Liu, Lei,et al. Application of functional vincristine plus dasatinib liposomes to deletion of vasculogenic mimicry channels in triple-negative breast cancer[J]. ONCOTARGET,2015,6(34):36625-36642.
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