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学科主题: 临床医学
题名:
The H63D Mutation of the Hemochromatosis Gene is Associated with Sustained Virological Response in Chronic Hepatitis C Patients Treated with Interferon-Based Therapy: A Meta-Analysis
作者: Li, Shi-Hong; Zhao, Hong; Ren, Yuan-Yuan; Liu, Yong-Zhe; Song, Ge; Ding, Peng; Ding, Yu-Ping; Wang, Gui-Qiang
关键词: chronic hepatitis c ; hemochromatosis ; interferon-based therapy ; mutation ; sustained virological response
刊名: TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
发表日期: 2012-04-01
DOI: 10.1620/tjem.226.293
卷: 226, 期:4, 页:293-299
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal ; Medicine, Research & Experimental
研究领域[WOS]: General & Internal Medicine ; Research & Experimental Medicine
关键词[WOS]: IRON-OVERLOAD ; HFE GENE ; VIRUS-INFECTION ; PLUS RIBAVIRIN ; IMMUNOLOGICAL MARKERS ; COMBINATION THERAPY ; INITIAL TREATMENT ; RANDOMIZED-TRIAL ; BLOOD-DONORS ; PROGRESSION
英文摘要:

The hemochromatosis (HFE) gene encodes the HFE protein that regulates iron absorption. HFE mutations lead to the hemochromatosis disease of excessive iron absorption. HFE mutations may also influence the sustained virologic response (SVR, long-term virus suppression) in chronic hepatitis C patients treated with interferon-based antiviral therapy. We performed a meta-analysis of all English and Chinese language studies of HFE mutations and SVR in interferon-treated chronic hepatitis C patients indexed in the Medline, Pub Med, Embase, and China National Knowledge Infrastructure databases to November 2011. Seven studies involving 605 patients with HFE mutations (homozygous or heterozygous mutation of C282Y, H63D or S65C) and 1279 with wild-type HFE (no mutation of C282Y, H63D or S65C for both alleles) were analyzed. Odds ratios (ORs) with 95% confidence intervals (Cis) were calculated with the fixed- or random-effect models. HFE mutations were associated with significantly higher SVR rate (vs. wild-type: OR = 1.56, 95% Cl: 1.23 - 1.97, P < 0.001), indicating that mutation carriers were likely to achieve SVR in response to interferon-based antiviral therapy. Stratification analysis by HFE mutation type revealed that the H63D mutation was associated with a significantly higher SVR rate (OR = 1.60, 95% Cl: 1.09 - 2.34, P = 0.020), while the C282Y mutation was not (OR = 1.19, 95% Cl: 0.71 - 1.98, P = 0.510). Our meta-analysis results indicate that the H63D mutation in HFE is associated with a higher SVR rate in chronic hepatitis C patients treated with interferon-based antiviral therapy.

语种: 英语
所属项目编号: 81170386
项目资助者: The National Natural Science Foundation of China ; Research Foundation of Peking University First Hospital
WOS记录号: WOS:000303302600007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59045
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

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作者单位: Peking Univ, Dept Infect Dis, Ctr Liver Dis, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Li, Shi-Hong,Zhao, Hong,Ren, Yuan-Yuan,et al. The H63D Mutation of the Hemochromatosis Gene is Associated with Sustained Virological Response in Chronic Hepatitis C Patients Treated with Interferon-Based Therapy: A Meta-Analysis[J]. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE,2012,226(4):293-299.
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