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The H63D Mutation of the Hemochromatosis Gene is Associated with Sustained Virological Response in Chronic Hepatitis C Patients Treated with Interferon-Based Therapy: A Meta-Analysis
Li, Shi-Hong; Zhao, Hong; Ren, Yuan-Yuan; Liu, Yong-Zhe; Song, Ge; Ding, Peng; Ding, Yu-Ping; Wang, Gui-Qiang
关键词chronic hepatitis c hemochromatosis interferon-based therapy mutation sustained virological response
刊名TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
2012-04-01
DOI10.1620/tjem.226.293
226期:4页:293-299
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal ; Medicine, Research & Experimental
研究领域[WOS]General & Internal Medicine ; Research & Experimental Medicine
关键词[WOS]IRON-OVERLOAD ; HFE GENE ; VIRUS-INFECTION ; PLUS RIBAVIRIN ; IMMUNOLOGICAL MARKERS ; COMBINATION THERAPY ; INITIAL TREATMENT ; RANDOMIZED-TRIAL ; BLOOD-DONORS ; PROGRESSION
英文摘要

The hemochromatosis (HFE) gene encodes the HFE protein that regulates iron absorption. HFE mutations lead to the hemochromatosis disease of excessive iron absorption. HFE mutations may also influence the sustained virologic response (SVR, long-term virus suppression) in chronic hepatitis C patients treated with interferon-based antiviral therapy. We performed a meta-analysis of all English and Chinese language studies of HFE mutations and SVR in interferon-treated chronic hepatitis C patients indexed in the Medline, Pub Med, Embase, and China National Knowledge Infrastructure databases to November 2011. Seven studies involving 605 patients with HFE mutations (homozygous or heterozygous mutation of C282Y, H63D or S65C) and 1279 with wild-type HFE (no mutation of C282Y, H63D or S65C for both alleles) were analyzed. Odds ratios (ORs) with 95% confidence intervals (Cis) were calculated with the fixed- or random-effect models. HFE mutations were associated with significantly higher SVR rate (vs. wild-type: OR = 1.56, 95% Cl: 1.23 - 1.97, P < 0.001), indicating that mutation carriers were likely to achieve SVR in response to interferon-based antiviral therapy. Stratification analysis by HFE mutation type revealed that the H63D mutation was associated with a significantly higher SVR rate (OR = 1.60, 95% Cl: 1.09 - 2.34, P = 0.020), while the C282Y mutation was not (OR = 1.19, 95% Cl: 0.71 - 1.98, P = 0.510). Our meta-analysis results indicate that the H63D mutation in HFE is associated with a higher SVR rate in chronic hepatitis C patients treated with interferon-based antiviral therapy.

语种英语
WOS记录号WOS:000303302600007
项目编号81170386
资助机构The National Natural Science Foundation of China ; Research Foundation of Peking University First Hospital
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59045
专题北京大学第一临床医学院_感染疾病科
作者单位Peking Univ, Dept Infect Dis, Ctr Liver Dis, Hosp 1, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Li, Shi-Hong,Zhao, Hong,Ren, Yuan-Yuan,et al. The H63D Mutation of the Hemochromatosis Gene is Associated with Sustained Virological Response in Chronic Hepatitis C Patients Treated with Interferon-Based Therapy: A Meta-Analysis[J]. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE,2012,226(4):293-299.
APA Li, Shi-Hong.,Zhao, Hong.,Ren, Yuan-Yuan.,Liu, Yong-Zhe.,Song, Ge.,...&Wang, Gui-Qiang.(2012).The H63D Mutation of the Hemochromatosis Gene is Associated with Sustained Virological Response in Chronic Hepatitis C Patients Treated with Interferon-Based Therapy: A Meta-Analysis.TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE,226(4),293-299.
MLA Li, Shi-Hong,et al."The H63D Mutation of the Hemochromatosis Gene is Associated with Sustained Virological Response in Chronic Hepatitis C Patients Treated with Interferon-Based Therapy: A Meta-Analysis".TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 226.4(2012):293-299.
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