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学科主题基础医学
Effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways in rats
Wang, Ning1; Zhang, Yang2; Wang, Jin-Yan1; Gao, Ge1; Luo, Fei1
关键词Anesthesia Laser Multiple Single-unit Recording
刊名NEUROSCIENCE BULLETIN
2010-06-01
DOI10.1007/s12264-010-0150-x
26期:3页:188-196
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]AWAKE ; POTENTIALS ; RECEPTOR ; GABA ; DESENSITIZATION ; INHIBITION ; PERCEPTION ; RESPONSES ; NEURONS ; CORTEX
英文摘要

Objective To investigate the effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways. Methods Laser stimulation was employed to evoke nociceptive responses in rats under awake or anesthetic conditions. Pain-related neuronal activities were simultaneously recorded from the primary somatosensory cortex (SI), ventral posterolateral thalamus (VPL), anterior cingulate cortex (ACC), and medial dorsal thalamus (MD) with 4 eight-wire microelectrode arrays. Results Compared with the awake state, pentobarbital anesthesia significantly suppressed the neural activities induced by noxious laser stimulation. Meanwhile, the pain-evoked changes in the neuronal correlations between cortex and thalamus were suppressed in both medial and lateral pain pathways. In addition, the spontaneous firing rates in all the 4 areas were altered (including inhibition and excitation) under the condition of anesthesia. Conclusion The nociceptive processing in the brain can be dramatically changed by anesthesia, which indicates that there are considerable differences in the brain activities between awake and anesthetized states. It is better to employ awake animals for recording neural activity when investigating the sensory coding mechanisms, especially pain coding, in order to obtain data that precisely reflect the physiological state.

语种英语
WOS记录号WOS:000295724200002
项目编号30700223 ; 30770688 ; 30970959 ; 5R03TW008038
资助机构National Natural Science Foundation of China ; Chinese Academy of Sciences ; NIH Fogarty International Center
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59051
专题北京大学基础医学院_神经生物学系
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
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GB/T 7714
Wang, Ning,Zhang, Yang,Wang, Jin-Yan,et al. Effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways in rats[J]. NEUROSCIENCE BULLETIN,2010,26(3):188-196.
APA Wang, Ning,Zhang, Yang,Wang, Jin-Yan,Gao, Ge,&Luo, Fei.(2010).Effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways in rats.NEUROSCIENCE BULLETIN,26(3),188-196.
MLA Wang, Ning,et al."Effects of pentobarbital anesthesia on nociceptive processing in the medial and lateral pain pathways in rats".NEUROSCIENCE BULLETIN 26.3(2010):188-196.
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