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学科主题: 基础医学
题名:
Plasmablastic lymphoma of the small intestine: Case report and literature review
作者: Wang, Hong-Wei1; Yang, Wen2; Sun, Jun-Zhong1; Lu, Jiang-Yang1; Li, Min3; Sun, Lin3
关键词: Plasmablastic lymphoma ; Small intestine ; Human immunodeficiency virus ; Differential diagnosis
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2012-12-07
DOI: 10.3748/wjg.v18.i45.6677
卷: 18, 期:45, 页:6677-6681
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: TRANSLOCATION ; INFECTION
英文摘要:

Plasmablastic lymphoma (PBL) is a rare aggressive B-cell lymphoproliferative disorder, which has been characterized by the World Health Organization as a new entity. Although PBL is most commonly seen in the oral cavity of human immunodeficiency virus (HIV)-positive patients, it can also be seen in extraoral sites in immnunocompromised patients who are HIV-negative. Here we present a rare case of PBL of the small intestine in a 55-year-old HIV-negative male. Histopathological examination of the excisional lesion showed a large cell lymphoma with plasmacytic differentiation diffusely infiltrating the small intestine and involving the surrounding organs. The neoplastic cells were diffusely positive for CD79a, CD138 and CD10 and partly positive for CD38 and epithelial membrane antigen. Approximately 80% of the tumor cells were positive for Ki-67. A monoclonal rearrangement of the kappa light chain gene was demonstrated. The patient died approximately 1.5 mo after diagnosis in spite of receiving two courses of the CHOP chemotherapy regimen. In a review of the literature, this is the first case report of PBL with initial presentation in the small intestine without HIV and Epstein-Barr vi-us infection, and a history of hepatitis B virus infection and radiotherapy probably led to the iatrogenic immunocompromised state. (C) 2012 Baishideng. All rights reserved.

语种: 英语
WOS记录号: WOS:000312476300023
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59052
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Gen Hosp Peoples Liberat Army, Dept Pathol, Affiliated Hosp 1, Beijing 100048, Peoples R China
2.Gen Hosp Peoples Liberat Army, Dept Obstet & Gynaecol, Beijing 100853, Peoples R China
3.Peking Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Hong-Wei,Yang, Wen,Sun, Jun-Zhong,et al. Plasmablastic lymphoma of the small intestine: Case report and literature review[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2012,18(45):6677-6681.
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