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学科主题临床医学
Comparison of long-term outcomes between older Asian and white patients with non-ST-segment elevation myocardial infarction: Findings from CRUSADE-CMS database
Xu, Weixian1; Holmes, DaJuanicia N.2; Becker, Richard C.2; Roe, Matthew T.2; Peterson, Eric D.2; Wang, Tracy Y.2
刊名AMERICAN HEART JOURNAL
2013-12-01
DOI10.1016/j.ahj.2013.10.001
166期:6页:1050-1055
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]CORONARY-HEART-DISEASE ; ETHNIC-DIFFERENCES ; MORTALITY ; COHORT ; REGISTRY ; TRIAL
英文摘要

Background In the United States as well as globally, Asians are a growing proportion of patients presenting with non-ST-segment elevation myocardial infarction (NSTEMI), yet little is known about their longitudinal outcomes.

Methods We linked Centers for Medicare & Medicaid claims data to detailed clinical data for 37,702 NSTEMI patients >= 65 years old treated at 444 CRUSADE hospitals between 2003 and 2006 to examine longitudinal outcomes. We used Cox proportional hazards modeling to compared outcomes between Asian and white patients, adjusting for differences in baseline patient characteristics.

Results Compared with white NSTEMI patients, Asians (n = 307) were younger; more frequently had hypertension, diabetes and renal insufficiency; and were less likely to have had a prior myocardial infarction, but there were no significant differences in rates of cardiac catheterization or revascularization during the index hospitalization between the 2 groups. At 30 days, Asian and white patients had a similar risk-adjusted mortality (9.5% vs 9.9%, P = .77), but by 1 year, Asian patients had a significantly lower risk-adjusted mortality (20.9% vs 24.5%, adjusted hazard ratio 0.64, 95% CI 0.50-0.82). Compared with white patients, Asians also had a lower adjusted 1-year cardiovascular readmission risk (37.1% vs 42.1%, adjusted hazard ratio 0.79, 95% CI 0.64-0.98).

Conclusions Despite similar inhospital treatments, Asian NSTEMI patients had lower mortality and cardiovascular readmission risks at 1 year, compared with white patients. Further study is needed to determine whether intrinsic ethnic differences or differential longitudinal prevention strategies explain these differences in long-term outcomes.

语种英语
WOS记录号WOS:000327536300016
资助机构Astra Zeneca ; Bayer Pharmaceuticals ; BMS ; Daiichi ; Eli Lilly ; Johnson Johnson ; Medicines Company ; Merck ; Momenta Pharmaceuticals ; Regado Biosciences, Inc ; Schering-Plough Research Institute ; Novartis ; Merck-Schering Plough ; Bristol-Myers Squibb ; American College of Cardiology ; American Heart Association ; BMS/Sanofi ; Daiichi Sankyo ; Glaxo Smith Kline ; Gilead Science
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59060
专题北京大学第三临床医学院
作者单位1.Peking Univ, Hosp 3, Beijing 100871, Peoples R China
2.Duke Clin Res Inst, Durham, NC 27705 USA
推荐引用方式
GB/T 7714
Xu, Weixian,Holmes, DaJuanicia N.,Becker, Richard C.,et al. Comparison of long-term outcomes between older Asian and white patients with non-ST-segment elevation myocardial infarction: Findings from CRUSADE-CMS database[J]. AMERICAN HEART JOURNAL,2013,166(6):1050-1055.
APA Xu, Weixian,Holmes, DaJuanicia N.,Becker, Richard C.,Roe, Matthew T.,Peterson, Eric D.,&Wang, Tracy Y..(2013).Comparison of long-term outcomes between older Asian and white patients with non-ST-segment elevation myocardial infarction: Findings from CRUSADE-CMS database.AMERICAN HEART JOURNAL,166(6),1050-1055.
MLA Xu, Weixian,et al."Comparison of long-term outcomes between older Asian and white patients with non-ST-segment elevation myocardial infarction: Findings from CRUSADE-CMS database".AMERICAN HEART JOURNAL 166.6(2013):1050-1055.
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