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学科主题: 临床医学
题名:
Outcomes of stage 1-5 chronic kidney disease in Mainland China
作者: Lai, Xuan; Zhang, Ai-Hua; Chen, Shao-Yan; He, Lian; Su, Chun-Yan; Fan, Min-Hua; Wang, Tao
关键词: Chronic kidney disease ; end stage renal disease ; mortality ; outcome ; risk factor
刊名: RENAL FAILURE
发表日期: 2014-05-01
DOI: 10.3109/0886022X.2013.875859
卷: 36, 期:4, 页:520-525
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: RENAL-DISEASE ; PROSPECTIVE COHORT ; POPULATION ; PREVALENCE ; CANCER ; PEOPLE ; DEATH
英文摘要:

Objective: This study aims to quantify and compare the risks of death and end stage renal disease (ESRD) in a prospective cohort of patients with chronic kidney disease (CKD) stages 1-5 under renal management clinic at Peking University Third Hospital and to evaluate the risk factors associated with these two outcomes. Method: This was a prospective cohort study. Finally, 1076 patients at CKD stage 1-5 short of dialysis were recruited from renal management clinic. Patients were monitored for up to Dec, 2011 or until ESRD and death. Glomerular filtration rate was estimated (eGFR) according to the using the CKD Epidemiology Collaboration (CKD-EPI) formula. Results: At the end of follow-up, 111 patients (10.1%) developed ESRD (initiated dialysis or kidney transplantation (ESRD)) and 24 patients (2.2%) had died. There were more ESRD occurrence rate in patients with baseline diabetic nephropathy, lower eGFR, hemoglobin <100 g/L and 24 h urinary protein excretion >= 3.0 g. By multivariate Cox regression model, having heavy proteinuria and CKD stage were the risk factors of ESRD. For all-cause mortality, the most common cause was cardiovascular disease, followed by infectious disease and cancer. But we failed to conclude any significant variable as risk factors for mortality in multivariate analysis. Conclusions: Our study indicated that baseline diabetic nephropathy, lower hemoglobin level, lower baseline GFR and heavy proteinuria were the risk factors of ESRD. In this CKD cohort, patients were more likely to develop ESRD than mortality, and cardiovascular mortality was the leading cause of death, and then followed by infectious diseases and cancer in this population.

语种: 英语
所属项目编号: 81170706 ; 81341022 ; YZZ05-5-34 ; SCW 2009-08
项目资助者: National Natural Science Foundation ; Peking University Third Hospital Key Program Grant ; Beijing Municipal Science &amp ; Technology commission
WOS记录号: WOS:000334936400006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59065
Appears in Collections:北京大学第三临床医学院_肾内科_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Nephrol, Beijing 100871, Peoples R China

Recommended Citation:
Lai, Xuan,Zhang, Ai-Hua,Chen, Shao-Yan,et al. Outcomes of stage 1-5 chronic kidney disease in Mainland China[J]. RENAL FAILURE,2014,36(4):520-525.
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