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学科主题临床医学
Age at onset of amyotrophic lateral sclerosis in China
Liu, M. S.1; Cui, L. Y.1; Fan, D. S.2; Chinese Als Assoc
关键词amyotrophic lateral sclerosis epidemiology clinical features risk factor
刊名ACTA NEUROLOGICA SCANDINAVICA
2014-03-01
DOI10.1111/ane.12157
129期:3页:163-167
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]MOTOR-NEURON DISEASE ; WESTERN WASHINGTON-STATE ; SURVIVAL PREDICTION ; CLINICAL-FEATURES ; RISK-FACTORS ; POPULATION ; ALS ; EPIDEMIOLOGY ; IRELAND ; FORM
英文摘要

BackgroundFor patients with amyotrophic lateral sclerosis (ALS), age at onset is not only a key factor for diagnosis and prognosis, but also a clue for exploring pathogenesis. Reports based on results from a single medical center suggested that the mean age at onset of ALS in China was earlier than in other developed countries. A larger, multicenter-based study is needed to confirm this finding.

MethodsA registry-based study of ALS was conducted at 10 ALS centers of the Chinese ALS Association from March 1, 2009 to August 31, 2009. The demographical and clinical features of patients with ALS were collected.

ResultsData from a total of 455 patients with ALS were available for analysis. The mean age at onset for the entire cohort was 52.412.1years. The peak age at onset was in the 45- to 49-year-old age group for women and the 55- to 59-year-old age group for men. The age at onset for patients from Guangzhou (a southern region) was significantly earlier than it was for patients from Shanghai (an eastern region) (t=2.270, P=0.025).

ConclusionsThis investigation confirmed the earlier age at onset of ALS in China as compared with other countries. Further population-based case-control investigations of genetic and environmental factors are needed to identify the potential risk factors for Chinese ALS patients.

语种英语
WOS记录号WOS:000330265600004
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59073
专题北京大学第三临床医学院_神经内科
作者单位1.Chinese Acad Med Sci, Dept Neurol, Peking Union Med Coll Hosp, Beijing 100730, Peoples R China
2.Peking Univ, Hosp 3, Dept Neurol, Beijing 100871, Peoples R China
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Liu, M. S.,Cui, L. Y.,Fan, D. S.,et al. Age at onset of amyotrophic lateral sclerosis in China[J]. ACTA NEUROLOGICA SCANDINAVICA,2014,129(3):163-167.
APA Liu, M. S.,Cui, L. Y.,Fan, D. S.,&Chinese Als Assoc.(2014).Age at onset of amyotrophic lateral sclerosis in China.ACTA NEUROLOGICA SCANDINAVICA,129(3),163-167.
MLA Liu, M. S.,et al."Age at onset of amyotrophic lateral sclerosis in China".ACTA NEUROLOGICA SCANDINAVICA 129.3(2014):163-167.
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