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学科主题: 临床医学
题名:
Significance of nonmucinous lepidic component with mild nuclear atypia in the discrimination of multiple primary lung cancers from intrapulmonary metastases
作者: Sun, Wei1; Liu, Yu2; Liu, Xiang-Yang3; Lin, Dong-Mei4; Lv, Ning1
关键词: Lepidic ; multifocal lung adenocarcinoma ; comprehensive histological assessment
刊名: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
发表日期: 2014
卷: 7, 期:11, 页:7583-7596
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Pathology
研究领域[WOS]: Oncology ; Pathology
关键词[WOS]: SURVIVAL FOLLOWING RESECTION ; ADENOMATOUS HYPERPLASIA ; PROGNOSTIC IMPLICATIONS ; SURGICAL-TREATMENT ; ADENOCARCINOMA ; CARCINOMA ; ORIGIN ; FEATURES ; CLASSIFICATION ; PROGRESSION
英文摘要:

The distinguishing of intrapulmonary metastases from multiple primaries is of great clinical importance. Although comprehensive histological assessment (CHA) was recommended for addressing this problem, the limitations of CHA have been addressed. We hypothesized that a nonmucinous lepidic component with mild nuclear atypia (NLCMA) may be one of the important sign suggesting primary lesions. In this study, we measured the value of NLCMA in distinguishing multiple primaries from intrapulmonary metastases. We retrospectively analyzed a cohort of 54 patients with 116 lesions (70 comparisons). Intrapulmonary metastases and multiple primaries were differentiated on the basis of CHA (Method I) and CHA combined with the assessment of NLCMA (Method II), respectively. Then, the results of two methods were compared with survival analysis. 33 cases were defined as multiple primaries and 21 cases as metastases by Method I, while 41 cases as multiple primaries and 13 cases as metastases by Method II. On univariate analysis, there was a better DFS in patients with a tumor <= 3 cm (P=0.012), female gender (P=0.011), highest N0 (P=0.002), absent micropapillary (P=0.013), multiple primaries (P=0.008 by method I, P < 0.001 by method II). A multivariate analysis adjusting for gender, tumor size, micropapillary and multiple primaries/metastases (by methodI and method II, respectively) indicated that multiple primaries (by method II) was an independent predictors for DFS. The presence of NLCMA may indicate that a lesion should be defined as primary in multifocal adenocarcinoma.

语种: 英语
所属项目编号: 2011-4002-01
项目资助者: Capital Medical Development Foundation
WOS记录号: WOS:000348345200029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59077
Appears in Collections:北京大学临床肿瘤学院_病理科_期刊论文

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作者单位: 1.Beijing Canc Hosp, Dept Pathol, Beijing 100142, Peoples R China
2.Chinese Acad Med Sci, Peking Union Med Coll, Canc Inst & Hosp, Dept Pathol, Beijing 100021, Peoples R China
3.Chinese Acad Med Sci, Peking Union Med Coll, Canc Inst & Hosp, Dept Etiol & Carcinogensis, Beijing 100021, Peoples R China
4.Chinese Acad Med Sci, Peking Union Med Coll, Canc Inst & Hosp, Div Thorac Oncol, Beijing 100021, Peoples R China

Recommended Citation:
Sun, Wei,Liu, Yu,Liu, Xiang-Yang,et al. Significance of nonmucinous lepidic component with mild nuclear atypia in the discrimination of multiple primary lung cancers from intrapulmonary metastases[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2014,7(11):7583-7596.
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