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Significance of nonmucinous lepidic component with mild nuclear atypia in the discrimination of multiple primary lung cancers from intrapulmonary metastases
Sun, Wei1; Liu, Yu2; Liu, Xiang-Yang3; Lin, Dong-Mei4; Lv, Ning1
关键词Lepidic multifocal lung adenocarcinoma comprehensive histological assessment
刊名INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
2014
7期:11页:7583-7596
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Pathology
研究领域[WOS]Oncology ; Pathology
关键词[WOS]SURVIVAL FOLLOWING RESECTION ; ADENOMATOUS HYPERPLASIA ; PROGNOSTIC IMPLICATIONS ; SURGICAL-TREATMENT ; ADENOCARCINOMA ; CARCINOMA ; ORIGIN ; FEATURES ; CLASSIFICATION ; PROGRESSION
英文摘要

The distinguishing of intrapulmonary metastases from multiple primaries is of great clinical importance. Although comprehensive histological assessment (CHA) was recommended for addressing this problem, the limitations of CHA have been addressed. We hypothesized that a nonmucinous lepidic component with mild nuclear atypia (NLCMA) may be one of the important sign suggesting primary lesions. In this study, we measured the value of NLCMA in distinguishing multiple primaries from intrapulmonary metastases. We retrospectively analyzed a cohort of 54 patients with 116 lesions (70 comparisons). Intrapulmonary metastases and multiple primaries were differentiated on the basis of CHA (Method I) and CHA combined with the assessment of NLCMA (Method II), respectively. Then, the results of two methods were compared with survival analysis. 33 cases were defined as multiple primaries and 21 cases as metastases by Method I, while 41 cases as multiple primaries and 13 cases as metastases by Method II. On univariate analysis, there was a better DFS in patients with a tumor <= 3 cm (P=0.012), female gender (P=0.011), highest N0 (P=0.002), absent micropapillary (P=0.013), multiple primaries (P=0.008 by method I, P < 0.001 by method II). A multivariate analysis adjusting for gender, tumor size, micropapillary and multiple primaries/metastases (by methodI and method II, respectively) indicated that multiple primaries (by method II) was an independent predictors for DFS. The presence of NLCMA may indicate that a lesion should be defined as primary in multifocal adenocarcinoma.

语种英语
WOS记录号WOS:000348345200029
项目编号2011-4002-01
资助机构Capital Medical Development Foundation
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59077
专题北京大学临床肿瘤学院_病理科
作者单位1.Beijing Canc Hosp, Dept Pathol, Beijing 100142, Peoples R China
2.Chinese Acad Med Sci, Peking Union Med Coll, Canc Inst & Hosp, Dept Pathol, Beijing 100021, Peoples R China
3.Chinese Acad Med Sci, Peking Union Med Coll, Canc Inst & Hosp, Dept Etiol & Carcinogensis, Beijing 100021, Peoples R China
4.Chinese Acad Med Sci, Peking Union Med Coll, Canc Inst & Hosp, Div Thorac Oncol, Beijing 100021, Peoples R China
推荐引用方式
GB/T 7714
Sun, Wei,Liu, Yu,Liu, Xiang-Yang,et al. Significance of nonmucinous lepidic component with mild nuclear atypia in the discrimination of multiple primary lung cancers from intrapulmonary metastases[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2014,7(11):7583-7596.
APA Sun, Wei,Liu, Yu,Liu, Xiang-Yang,Lin, Dong-Mei,&Lv, Ning.(2014).Significance of nonmucinous lepidic component with mild nuclear atypia in the discrimination of multiple primary lung cancers from intrapulmonary metastases.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,7(11),7583-7596.
MLA Sun, Wei,et al."Significance of nonmucinous lepidic component with mild nuclear atypia in the discrimination of multiple primary lung cancers from intrapulmonary metastases".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 7.11(2014):7583-7596.
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