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学科主题临床医学
High-Resolution Melting Analysis of BLU Methylation Levels in Gastric, Colorectal, and Pancreatic Cancers
Shao, Yong1,2; Zhang, Wei3,4; Zhang, Chao2; Wu, Qi2; Yang, Hong2,5; Zhang, Jie1; Guan, Ming6; Wan, Jun2,4; Yu, Bo1,2
关键词BLU Methylation HRM Gastric cancer Colorectal cancer Pancreatic cancer
刊名CANCER INVESTIGATION
2010-07-01
DOI10.3109/07357901003631023
28期:6页:642-648
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]TUMOR-SUPPRESSOR GENES ; REAL-TIME PCR ; DNA METHYLATION ; LUNG-CANCER ; NASOPHARYNGEAL CARCINOMA ; CELL-LINES ; 3P21.3 ; HYPERMETHYLATION ; INACTIVATION ; SENSITIVITY
英文摘要

BLU was recently characterized as a novel tumor suppressor gene (TSG), and was epigenetically silenced in some tumor cell lines and primary tumor samples. High-resolution melting (HRM) analysis has been used as a novel tool for analysis of promoter methylation. We used HRM analysis to detect the methylation levels of BLU gene in 100 gastric, 100 colorectal, and 70 pancreatic cancers, and also in an equal number of adjacent normal tissues for all. The frequency of BLU methylation in all three types of cancer was significantly higher than that in normal tissues. And the expression levels of BLU were inversely correlated with methylation levels.

语种英语
WOS记录号WOS:000278740000009
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59080
专题北京大学深圳医院_皮肤性病科
北京大学临床肿瘤学院_护理部
作者单位1.Peking Univ, Shenzhen Hosp, Dept Dermatol, Shenzhen, Guangdong, Peoples R China
2.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen, Guangdong, Peoples R China
3.Ji Nan Univ, HKUST JNU Joint Lab, Guangzhou, Guangdong, Peoples R China
4.Hong Kong Univ Sci & Technol, Dept Biochem, Hong Kong, Hong Kong, Peoples R China
5.Peking Univ, Shenzhen Hosp, Dept Clin Lab, Shenzhen, Guangdong, Peoples R China
6.Fudan Univ, Dept Lab Med, Cent Lab, Huashan Hosp, Shanghai 200433, Peoples R China
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Shao, Yong,Zhang, Wei,Zhang, Chao,et al. High-Resolution Melting Analysis of BLU Methylation Levels in Gastric, Colorectal, and Pancreatic Cancers[J]. CANCER INVESTIGATION,2010,28(6):642-648.
APA Shao, Yong.,Zhang, Wei.,Zhang, Chao.,Wu, Qi.,Yang, Hong.,...&Yu, Bo.(2010).High-Resolution Melting Analysis of BLU Methylation Levels in Gastric, Colorectal, and Pancreatic Cancers.CANCER INVESTIGATION,28(6),642-648.
MLA Shao, Yong,et al."High-Resolution Melting Analysis of BLU Methylation Levels in Gastric, Colorectal, and Pancreatic Cancers".CANCER INVESTIGATION 28.6(2010):642-648.
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