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学科主题: 临床医学
题名:
High-Resolution Melting Analysis of BLU Methylation Levels in Gastric, Colorectal, and Pancreatic Cancers
作者: Shao, Yong1,2; Zhang, Wei3,4; Zhang, Chao2; Wu, Qi2; Yang, Hong2,5; Zhang, Jie1; Guan, Ming6; Wan, Jun2,4; Yu, Bo1,2
关键词: BLU ; Methylation ; HRM ; Gastric cancer ; Colorectal cancer ; Pancreatic cancer
刊名: CANCER INVESTIGATION
发表日期: 2010-07-01
DOI: 10.3109/07357901003631023
卷: 28, 期:6, 页:642-648
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: TUMOR-SUPPRESSOR GENES ; REAL-TIME PCR ; DNA METHYLATION ; LUNG-CANCER ; NASOPHARYNGEAL CARCINOMA ; CELL-LINES ; 3P21.3 ; HYPERMETHYLATION ; INACTIVATION ; SENSITIVITY
英文摘要:

BLU was recently characterized as a novel tumor suppressor gene (TSG), and was epigenetically silenced in some tumor cell lines and primary tumor samples. High-resolution melting (HRM) analysis has been used as a novel tool for analysis of promoter methylation. We used HRM analysis to detect the methylation levels of BLU gene in 100 gastric, 100 colorectal, and 70 pancreatic cancers, and also in an equal number of adjacent normal tissues for all. The frequency of BLU methylation in all three types of cancer was significantly higher than that in normal tissues. And the expression levels of BLU were inversely correlated with methylation levels.

语种: 英语
WOS记录号: WOS:000278740000009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59080
Appears in Collections:北京大学深圳医院_皮肤性病科_期刊论文

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作者单位: 1.Peking Univ, Shenzhen Hosp, Dept Dermatol, Shenzhen, Guangdong, Peoples R China
2.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen, Guangdong, Peoples R China
3.Ji Nan Univ, HKUST JNU Joint Lab, Guangzhou, Guangdong, Peoples R China
4.Hong Kong Univ Sci & Technol, Dept Biochem, Hong Kong, Hong Kong, Peoples R China
5.Peking Univ, Shenzhen Hosp, Dept Clin Lab, Shenzhen, Guangdong, Peoples R China
6.Fudan Univ, Dept Lab Med, Cent Lab, Huashan Hosp, Shanghai 200433, Peoples R China

Recommended Citation:
Shao, Yong,Zhang, Wei,Zhang, Chao,et al. High-Resolution Melting Analysis of BLU Methylation Levels in Gastric, Colorectal, and Pancreatic Cancers[J]. CANCER INVESTIGATION,2010,28(6):642-648.
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