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学科主题: 药学
题名:
New inhibitors of nitric oxide production from the seeds of Myristica fragrans
作者: Cao, Gui-Yun1; Yang, Xiu-Wei1; Xu, Wei1; Li, Fei2
关键词: Myristica fragrans ; Nutmeg ; Myrisfrageal A ; Myrisfrageal B ; Nitric oxide ; Inducible nitric oxide synthase
刊名: FOOD AND CHEMICAL TOXICOLOGY
发表日期: 2013-12-01
DOI: 10.1016/j.fct.2013.08.046
卷: 62, 页:167-171
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Food Science & Technology ; Toxicology
研究领域[WOS]: Food Science & Technology ; Toxicology
关键词[WOS]: NUTMEG ; EXTRACT ; MACELIGNAN ; NEOLIGNANS ; LIGNANS ; INJURY ; PLANTS ; CELLS
英文摘要:

Six dihydrobenzofuran type neolignans were isolated from the dried ripe seeds of Myristica fragrans Houtt. (family: Myristicaceae) and their chemical structures were identified as licarin B (1), 3′-methoxylicarin B (2), myrisfrageal A (3), isodihydrocainatidin (4), dehydrodiisoeugenol (5), and myrisfrageal B (6), respectively, on the basis of spectroscopic data analyses. Among them, compounds 3 and 6 are new compounds. Compounds 1-6 showed inhibition of nitric oxide production in lipopolysaccharide-activated murine monocyte-macrophage RAW264.7 with IC50 values of 53.6, 48.7, 76.0, 36.0, 33.6, and 45.0 mu M, respectively. These values were compared to those of the positive controls, indomethacin and L-N-6-(1-iminoethyl)-lysine, which have IC50 values of 65.3 and 27.1 mu M, respectively. Further compounds 3, 5 and 6 suppressed LPS-induced iNOS mRNA expression in a does-dependent manner in RAW 264.7 cells assayed by real-time RT-PCR. Compounds 3,5 and 6 may inhibit NO overproduction via inhibition of iNOS mRNA expression. The results provided valuable information for further investigation of compounds 1-6 as anti-inflammatory and chemopreventive agents. (C) 2013 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 30973863 ; 2011BAI07B08
项目资助者: National Natural Science Foundation of China ; National Key Technology R &amp ; D Program of China
WOS记录号: WOS:000329960400022
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59086
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Nat Med,State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.NCI, NIH, Ctr Canc Res, Lab Metab, Bethesda, MD 20892 USA

Recommended Citation:
Cao, Gui-Yun,Yang, Xiu-Wei,Xu, Wei,et al. New inhibitors of nitric oxide production from the seeds of Myristica fragrans[J]. FOOD AND CHEMICAL TOXICOLOGY,2013,62:167-171.
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