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学科主题: 临床医学
题名:
Hemodynamic effects of various support modes of continuous flow LVADs on the cardiovascular system: A numerical study
作者: Song, Zhiming1; Gu, Kaiyun2; Gao, Bin2; Wan, Feng1; Chang, Yu2; Zeng, Yi2
关键词: Blood Flow Velocity ; Heart Failure ; Ventricular Function, Left
刊名: MEDICAL SCIENCE MONITOR
发表日期: 2014-05-05
卷: 20, 页:733-741
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: VENTRICULAR ASSIST DEVICE ; ROTARY BLOOD PUMPS ; INTRA-AORTA PUMP ; HEART RECOVERY ; PULSATILE ; PERFUSION ; PRESSURE ; SPEED ; INSUFFICIENCY ; CONTROLLER
英文摘要:

Background: The aim of this study was to determine the hemodynamic effects of various support modes of continuous flow left ventricular assist devices (CF-LVADs) on the cardiovascular system using a numerical cardiovascular system model.

Material/Methods: Three support modes were selected for controlling the CF-LVAD: constant flow mode, constant speed mode, and constant pressure head mode of CF-LVAD. The CF-LVAD is established between the left ventricular apex and the ascending aorta, and was incorporated into the numerical model. Various parameters were evaluated, including the blood assist index (BAI), the left ventricular external work (LVEW), the energy of blood flow (EBF), pulsatility index (PI), and surplus hemodynamic energy (SHE).

Results: The results show that the constant flow mode, when compared to the constant speed mode and the constant pressure head mode, increases LVEW by 31% and 14%, and EBF by 21% and 15%, respectively, indicating that this mode achieved the best ventricular unloading among the 3 support modes. As BAI is increased, PI and SHE are gradually decreased, whereas PI of the constant pressure head reaches the maximum value.

Conclusions: The study demonstrates that the continuous flow control mode of the CF-LVAD may achieve the highest ventricular unloading. In contrast, the constant rotational speed mode permits the optimal blood perfusion. Finally, the constant pressure head strategy, permitting optimal pulsatility, should optimize the vascular function.

语种: 英语
所属项目编号: 11272022 ; 1122001 ; 1372014 ; 015000514312002 ; 015000543114506
项目资助者: National Natural Science Foundation of China ; Fundamental Research Foundation of BJUT ; Jinghua Foundation of BJUT ; Rixinhoubei Foundation of BJUT
WOS记录号: WOS:000335381500001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59088
Appears in Collections:北京大学第三临床医学院_心脏外科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Cardiac Surg, Beijing 100871, Peoples R China
2.Beijing Univ Technol, Sch Life Sci & Bioengn, Beijing, Peoples R China

Recommended Citation:
Song, Zhiming,Gu, Kaiyun,Gao, Bin,et al. Hemodynamic effects of various support modes of continuous flow LVADs on the cardiovascular system: A numerical study[J]. MEDICAL SCIENCE MONITOR,2014,20:733-741.
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