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学科主题: 药学
题名:
Circulating microRNA-122 as a potential biomarker for liver injury
作者: Ding, Xianfeng1; Ding, Jianv1; Ning, Jing3,5,6; Yi, Fan2; Chen, Jiankui5; Zhao, Deyao1; Zheng, Jiaping4; Liang, Zicai2; Hu, Zhiyuan3; Du, Quan2,7
关键词: circulating microRNA ; biomarker ; liver injury
刊名: MOLECULAR MEDICINE REPORTS
发表日期: 2012-06-01
DOI: 10.3892/mmr.2012.838
卷: 5, 期:6, 页:1428-1432
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Medicine, Research & Experimental
研究领域[WOS]: Oncology ; Research & Experimental Medicine
关键词[WOS]: C VIRUS-INFECTION ; IN-VIVO ; IDENTIFICATION ; DIAGNOSIS ; PRIMATES ; MIR-122 ; CANCER ; TESTS ; SERUM
英文摘要:

Liver-specific microRNA-122 (miR-122) is involved in the replication of hepatitis C virus (HCV) and its potential as a target for antiviral intervention was recently assessed. However, the use of circulating miR-122 in the evaluation of liver function has never been reported. In the present study, changes of serum miRNA levels were first evaluated in acute human hepatotoxicity due to paraquat exposure. Serum samples were collected and analyzed using real-time reverse transcription PCR. The results showed a positive correlation between serum miR-122 and alanine aminotransferase, a clinical biomarker for liver function. Furthermore, serum miR-122 was assessed in patients with hepatitis B and hepatocarcinoma, resulting in distinct miR-122 profiles in these two closely related diseases. In addition to miR-122, another small RNA, U6 small nuclear RNA, was downregulated in hepatocarcinoma patients, suggesting its prognostic significance in this disease. Taken together, these lines of evidence indicate that serum miR-122 may provide a biomarker for diverse liver diseases and, more importantly, suggest that a combination of nucleic acid biomarkers may be used as a sensitive and specific index for discriminating closely related diseases.

语种: 英语
所属项目编号: 2011B090400478 ; 2007AA02Z165 ; 30873187 ; 30771085 ; 30871385 ; Y2100681 ; 5092011 ; 2009ZX09503 ; SKLP-K200903 ; 2007CB512100
项目资助者: Guangdong Science and Technology Department ; National High-tech R&amp ; D Program of China ; National Natural Science Foundation of China ; Zhejiang Natural Science Foundation ; Beijing Natural Science Foundation ; National Drug Program ; National Basic Research Program of China
WOS记录号: WOS:000304182300010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59090
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Inst Mol Med, Beijing 100871, Peoples R China
2.Zhejiang Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
3.Zhejiang Sci Tech Univ, Sch Life Sci, Hangzhou 310018, Zhejiang, Peoples R China
4.Beijing Proteome Res Ctr, State Key Lab Prote, Beijing 102206, Peoples R China
5.Acad Mil Med Sci, Affiliated Hosp, Dept Lab Med, Beijing 100071, Peoples R China
6.Chinese Peoples Armed Police Forces, Beijing Municipal Corps Hosp, Dept Lab Med, Beijing 100027, Peoples R China
7.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Ding, Xianfeng,Ding, Jianv,Ning, Jing,et al. Circulating microRNA-122 as a potential biomarker for liver injury[J]. MOLECULAR MEDICINE REPORTS,2012,5(6):1428-1432.
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