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Circulating microRNA-122 as a potential biomarker for liver injury
Ding, Xianfeng1; Ding, Jianv1; Ning, Jing3,5,6; Yi, Fan2; Chen, Jiankui5; Zhao, Deyao1; Zheng, Jiaping4; Liang, Zicai2; Hu, Zhiyuan3; Du, Quan2,7
关键词circulating microRNA biomarker liver injury
刊名MOLECULAR MEDICINE REPORTS
2012-06-01
DOI10.3892/mmr.2012.838
5期:6页:1428-1432
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Medicine, Research & Experimental
研究领域[WOS]Oncology ; Research & Experimental Medicine
关键词[WOS]C VIRUS-INFECTION ; IN-VIVO ; IDENTIFICATION ; DIAGNOSIS ; PRIMATES ; MIR-122 ; CANCER ; TESTS ; SERUM
英文摘要

Liver-specific microRNA-122 (miR-122) is involved in the replication of hepatitis C virus (HCV) and its potential as a target for antiviral intervention was recently assessed. However, the use of circulating miR-122 in the evaluation of liver function has never been reported. In the present study, changes of serum miRNA levels were first evaluated in acute human hepatotoxicity due to paraquat exposure. Serum samples were collected and analyzed using real-time reverse transcription PCR. The results showed a positive correlation between serum miR-122 and alanine aminotransferase, a clinical biomarker for liver function. Furthermore, serum miR-122 was assessed in patients with hepatitis B and hepatocarcinoma, resulting in distinct miR-122 profiles in these two closely related diseases. In addition to miR-122, another small RNA, U6 small nuclear RNA, was downregulated in hepatocarcinoma patients, suggesting its prognostic significance in this disease. Taken together, these lines of evidence indicate that serum miR-122 may provide a biomarker for diverse liver diseases and, more importantly, suggest that a combination of nucleic acid biomarkers may be used as a sensitive and specific index for discriminating closely related diseases.

语种英语
WOS记录号WOS:000304182300010
项目编号2011B090400478 ; 2007AA02Z165 ; 30873187 ; 30771085 ; 30871385 ; Y2100681 ; 5092011 ; 2009ZX09503 ; SKLP-K200903 ; 2007CB512100
资助机构Guangdong Science and Technology Department ; National High-tech R&amp ; D Program of China ; National Natural Science Foundation of China ; Zhejiang Natural Science Foundation ; Beijing Natural Science Foundation ; National Drug Program ; National Basic Research Program of China
引用统计
被引频次:45[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59090
专题北京大学药学院
作者单位1.Peking Univ, Inst Mol Med, Beijing 100871, Peoples R China
2.Zhejiang Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
3.Zhejiang Sci Tech Univ, Sch Life Sci, Hangzhou 310018, Zhejiang, Peoples R China
4.Beijing Proteome Res Ctr, State Key Lab Prote, Beijing 102206, Peoples R China
5.Acad Mil Med Sci, Affiliated Hosp, Dept Lab Med, Beijing 100071, Peoples R China
6.Chinese Peoples Armed Police Forces, Beijing Municipal Corps Hosp, Dept Lab Med, Beijing 100027, Peoples R China
7.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
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GB/T 7714
Ding, Xianfeng,Ding, Jianv,Ning, Jing,et al. Circulating microRNA-122 as a potential biomarker for liver injury[J]. MOLECULAR MEDICINE REPORTS,2012,5(6):1428-1432.
APA Ding, Xianfeng.,Ding, Jianv.,Ning, Jing.,Yi, Fan.,Chen, Jiankui.,...&Du, Quan.(2012).Circulating microRNA-122 as a potential biomarker for liver injury.MOLECULAR MEDICINE REPORTS,5(6),1428-1432.
MLA Ding, Xianfeng,et al."Circulating microRNA-122 as a potential biomarker for liver injury".MOLECULAR MEDICINE REPORTS 5.6(2012):1428-1432.
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