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学科主题: 临床医学
题名:
Analysis of clinical and dosimetric factors associated with severe acute radiation pneumonitis in patients with locally advanced non-small cell lung cancer treated with concurrent chemotherapy and intensity-modulated radiotherapy
作者: Shi, Anhui; Zhu, Guangying; Wu, Hao; Yu, Rong; Li, Fuhai; Xu, Bo
刊名: RADIATION ONCOLOGY
发表日期: 2010-05-12
DOI: 10.1186/1748-717X-5-35
卷: 5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Oncology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: DOSE-VOLUME HISTOGRAM ; THORACIC IRRADIATION ; CONFORMAL RADIOTHERAPY ; RISK-FACTORS ; THERAPY ; PARAMETERS ; NSCLC ; CHEMORADIATION ; CARBOPLATIN ; REDUCTION
英文摘要:

Background: To evaluate the association between the clinical, dosimetric factors and severe acute radiation pneumonitis (SARP) in patients with locally advanced non-small cell lung cancer (LANSCLC) treated with concurrent chemotherapy and intensity-modulated radiotherapy (IMRT).

Methods: We analyzed 94 LANSCLC patients treated with concurrent chemotherapy and IMRT between May 2005 and September 2006. SARP was defined as greater than or equal 3 side effects and graded according to Common Terminology Criteria for Adverse Events (CTCAE) version 3.0. The clinical and dosimetric factors were analyzed. Univariate and multivariate logistic regression analyses were performed to evaluate the relationship between clinical, dosimetric factors and SARP.

Results: Median follow-up was 10.5 months (range 6.5-24). Of 94 patients, 11 (11.7%) developed SARP. Univariate analyses showed that the normal tissue complication probability (NTCP), mean lung dose (MLD), relative volumes of lung receiving more than a threshold dose of 5-60 Gy at increments of 5 Gy (V5-V60), chronic obstructive pulmonary disease (COPD) and Forced Expiratory Volume in the first second (FEV1) were associated with SARP (p < 0.05). In multivariate analysis, NTCP value (p = 0.001) and V10 (p = 0.015) were the most significant factors associated with SARP. The incidences of SARP in the group with NTCP > 4.2% and NTCP <= 4.2% were 43.5% and 1.4%, respectively (p < 0.01). The incidences of SARP in the group with V10 <= 50% and V10 > 50% were 5.7% and 29.2%, respectively (p < 0.01).

Conclusions: NTCP value and V10 are the useful indicators for predicting SARP in NSCLC patients treated with concurrent chemotherapy and IMRT.

语种: 英语
所属项目编号: 30870738
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000279294900001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59092
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst,Minist Educ, Dept Radiat Oncol,Key Lab Carcinogenesis & Transl, Beijing 100142, Peoples R China

Recommended Citation:
Shi, Anhui,Zhu, Guangying,Wu, Hao,et al. Analysis of clinical and dosimetric factors associated with severe acute radiation pneumonitis in patients with locally advanced non-small cell lung cancer treated with concurrent chemotherapy and intensity-modulated radiotherapy[J]. RADIATION ONCOLOGY,2010,5.
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