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学科主题: 药学
题名:
Orally delivered salmon calcitonin-loaded solid lipid nanoparticles prepared by micelle-double emulsion method via the combined use of different solid lipids
作者: Chen, Chunhui1; Fan, Tingting1; Jin, Yun1; Zhou, Zhou1; Yang, Yang1; Zhu, Xi1; Zhang, Zhi-rong1; Zhang, Qiang2; Huang, Yuan1
关键词: bioavailability ; combined solid lipid ; micelle-double emulsion technique ; salmon calcitonin ; solid lipid nanoparticle ; uptake
刊名: NANOMEDICINE
发表日期: 2013-07-01
DOI: 10.2217/NNM.12.141
卷: 8, 期:7, 页:1085-1100
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Nanoscience & Nanotechnology
研究领域[WOS]: Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
关键词[WOS]: IN-VITRO ; VIVO CHARACTERIZATION ; PEPTIDE DELIVERY ; SODIUM CHOLATE ; BILE-SALTS ; INSULIN ; SLN ; BIOAVAILABILITY ; ASSOCIATION ; CHITOSAN
英文摘要:

The purpose of this study was to develop a new orally delivered nanoparticulate system to improve the bioavailability of salmon calcitonin (sCT). Materials & methods: Four sCT-loaded solid lipid nanoparticles (SLNs) were prepared successfully by micelle-double emulsion technique via either the sole use of stearic acid (SA) or the combined use of SA and triglycerides (including tripalmitin [TP], trimyristin or trilaurin). Results: Compared with other SLNs, the combination of SA and TP could not only significantly improve the colloidal stability of SLNs and enhance the drug stability in the simulated intestinal fluids, but also intensively increase the intracellular uptake of drugs compared with the other SLNs (p < 0.05). The mechanism of internalization was an active transport involved in clathrin-and caveolae-dependent endocytosis. In vivo, the sCT SLNs prepared with SA and TP exhibited the highest reduction of plasma Ca2+ level (17.44 +/- 3.68%) with a bioavailability of 13.01 +/- 3.24%. Conclusion: The SLNs formed by SA and TP as the solid lipids may be a promising carrier for oral delivery of peptide drugs.

语种: 英语
所属项目编号: 2009ZX09503-026 ; 81173010 ; 2009CB903300
项目资助者: 11th Five-Year Plan National Key Technology Research and Development Program for New Drug RD ; National Natural Science Foundation of China ; National Basic Research Program of China (973 Program)
WOS记录号: WOS:000320853500014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59095
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Sichuan Univ, Key Lab Drug Targeting & Drug Delivery Syst, Minist Educ, West China Sch Pharm, Chengdu 610041, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Chen, Chunhui,Fan, Tingting,Jin, Yun,et al. Orally delivered salmon calcitonin-loaded solid lipid nanoparticles prepared by micelle-double emulsion method via the combined use of different solid lipids[J]. NANOMEDICINE,2013,8(7):1085-1100.
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