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Orally delivered salmon calcitonin-loaded solid lipid nanoparticles prepared by micelle-double emulsion method via the combined use of different solid lipids
Chen, Chunhui1; Fan, Tingting1; Jin, Yun1; Zhou, Zhou1; Yang, Yang1; Zhu, Xi1; Zhang, Zhi-rong1; Zhang, Qiang2; Huang, Yuan1
关键词bioavailability combined solid lipid micelle-double emulsion technique salmon calcitonin solid lipid nanoparticle uptake
刊名NANOMEDICINE
2013-07-01
DOI10.2217/NNM.12.141
8期:7页:1085-1100
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Nanoscience & Nanotechnology
研究领域[WOS]Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
关键词[WOS]IN-VITRO ; VIVO CHARACTERIZATION ; PEPTIDE DELIVERY ; SODIUM CHOLATE ; BILE-SALTS ; INSULIN ; SLN ; BIOAVAILABILITY ; ASSOCIATION ; CHITOSAN
英文摘要

The purpose of this study was to develop a new orally delivered nanoparticulate system to improve the bioavailability of salmon calcitonin (sCT). Materials & methods: Four sCT-loaded solid lipid nanoparticles (SLNs) were prepared successfully by micelle-double emulsion technique via either the sole use of stearic acid (SA) or the combined use of SA and triglycerides (including tripalmitin [TP], trimyristin or trilaurin). Results: Compared with other SLNs, the combination of SA and TP could not only significantly improve the colloidal stability of SLNs and enhance the drug stability in the simulated intestinal fluids, but also intensively increase the intracellular uptake of drugs compared with the other SLNs (p < 0.05). The mechanism of internalization was an active transport involved in clathrin-and caveolae-dependent endocytosis. In vivo, the sCT SLNs prepared with SA and TP exhibited the highest reduction of plasma Ca2+ level (17.44 +/- 3.68%) with a bioavailability of 13.01 +/- 3.24%. Conclusion: The SLNs formed by SA and TP as the solid lipids may be a promising carrier for oral delivery of peptide drugs.

语种英语
WOS记录号WOS:000320853500014
项目编号2009ZX09503-026 ; 81173010 ; 2009CB903300
资助机构11th Five-Year Plan National Key Technology Research and Development Program for New Drug RD ; National Natural Science Foundation of China ; National Basic Research Program of China (973 Program)
引用统计
被引频次:30[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59095
专题北京大学药学院
北京大学药学院_药剂学系
作者单位1.Sichuan Univ, Key Lab Drug Targeting & Drug Delivery Syst, Minist Educ, West China Sch Pharm, Chengdu 610041, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Chen, Chunhui,Fan, Tingting,Jin, Yun,et al. Orally delivered salmon calcitonin-loaded solid lipid nanoparticles prepared by micelle-double emulsion method via the combined use of different solid lipids[J]. NANOMEDICINE,2013,8(7):1085-1100.
APA Chen, Chunhui.,Fan, Tingting.,Jin, Yun.,Zhou, Zhou.,Yang, Yang.,...&Huang, Yuan.(2013).Orally delivered salmon calcitonin-loaded solid lipid nanoparticles prepared by micelle-double emulsion method via the combined use of different solid lipids.NANOMEDICINE,8(7),1085-1100.
MLA Chen, Chunhui,et al."Orally delivered salmon calcitonin-loaded solid lipid nanoparticles prepared by micelle-double emulsion method via the combined use of different solid lipids".NANOMEDICINE 8.7(2013):1085-1100.
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