IR@PKUHSC  > 北京大学口腔医学院  > 儿童口腔科
学科主题口腔医学
Root resorption of primary molars without successor teeth. An experimental study in the beagle dog
Lin, Bi-Chen; Zhao, Yu-Ming; Yang, Jie; Ge, Li-Hong
关键词dog odontoclast receptor activator of nuclear factor-?B (RANK) root resorption
刊名EUROPEAN JOURNAL OF ORAL SCIENCES
2012-04-01
DOI10.1111/j.1600-0722.2012.00950.x
120期:2页:147-152
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
资助者National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education of China ; National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education of China
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]HUMAN DECIDUOUS TEETH ; REGULATES OSTEOCLAST DIFFERENTIATION ; DENTAL FOLLICLE ; TOOTH ERUPTION ; LIGAND ; CELLS
英文摘要

Tooth agenesis is a common craniofacial congenital malformation in humans, but little is known about the mechanisms of root resorption in this condition. The purpose of this study was to investigate the mechanisms of root resorption in primary molars without successors. An animal model without permanent tooth germs was established by surgery in beagles. The times of onset of primary molar root resorption, with and without successors, were compared. The distribution of immune cells, odontoclasts, and their activating factors were determined by histochemistry and immunohistochemistry. Root resorption of primary mandibular molars without successors began later than physiological resorption. In primary molars without permanent germs, odontoclasts and immune cells were present mainly in the apical pulp at the start of root resorption, whereas in control teeth receptor activator of nuclear factor-jB ligand (RANKL)-positive cells were found mainly in the region of the periodontal ligament. CD14 + and CD3 + cells were found in both the pulp and the periodontal ligament region. These results suggest that the dental pulp of primary molars, as well as immune cells, may play an important role in root resorption in primary molars without permanent tooth germs.

语种英语
所属项目编号30672321 ; 20070001729
资助者National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education of China ; National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education of China
WOS记录号WOS:000301350500007
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59096
Collection北京大学口腔医学院_儿童口腔科
作者单位Peking Univ Sch & Hosp Stomatol, Dept Pediat Dent, Beijing 100081, Peoples R China
Recommended Citation
GB/T 7714
Lin, Bi-Chen,Zhao, Yu-Ming,Yang, Jie,et al. Root resorption of primary molars without successor teeth. An experimental study in the beagle dog[J]. EUROPEAN JOURNAL OF ORAL SCIENCES,2012,120(2):147-152.
APA Lin, Bi-Chen,Zhao, Yu-Ming,Yang, Jie,&Ge, Li-Hong.(2012).Root resorption of primary molars without successor teeth. An experimental study in the beagle dog.EUROPEAN JOURNAL OF ORAL SCIENCES,120(2),147-152.
MLA Lin, Bi-Chen,et al."Root resorption of primary molars without successor teeth. An experimental study in the beagle dog".EUROPEAN JOURNAL OF ORAL SCIENCES 120.2(2012):147-152.
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