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学科主题: 临床医学
题名:
Human 1A6/DRIM, the homolog of yeast Utp20, functions in the 18S rRNA processing
作者: Wang, You; Liu, Jiangying; Zhao, Hong; Lue, Wenqing; Zhao, Jun; Yang, Lin; Li, Ning; Du, Xiaojuan; Ke, Yang
关键词: 1A6/DRIM ; UTP20 ; 18S rRNA processing ; U3 snoRNA
刊名: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
发表日期: 2007-06-01
DOI: 10.1016/j.bbamcr.2007.04.002
卷: 1773, 期:6, 页:863-868
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]: SMALL NUCLEOLAR RIBONUCLEOPROTEIN ; SMALL-SUBUNIT PROCESSOME ; SMALL NUCLEAR-RNA ; BOX B/C MOTIF ; U3 SNORNP ; GENE-EXPRESSION ; PRE-RIBOSOMES ; CELL-LINES ; PROTEIN ; BIOGENESIS
英文摘要:

1A6/DRIM is a nucleolar protein with a nucleolar targeting sequence in its 3′-terminus. Bioinformatic analysis indicated that human 1A6/ DRIM shares 23% identity and 43% similarity with yeast Utp20, which has been reported as a component of U3 snoRNA protein complex and has been implicated in 18S rRNA processing. In the present study, we found, by utilizing RT-PCR with RNA extracted from anti-1A6/DRIM inummoprecipitates and Northern blotting, that 1A6/DRIM is associated with U3 snoRNA. Pulse-chase labeling assays showed that silencing of 1A6/DRIM expression in HeLa cells resulted in a delayed 18S rRNA processing. Furthermore, immunoprecipitations revealed that 1A6/DRIM was also associated with fibrillarin, another U3 RNP component in HeLa cells. These results indicate that 1A6/DRIM is involved in 18S rRNA processing and is the bona fide mammalian Utp20. (c) 2007 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000247495800019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59100
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Beijing Inst Canc Res, Beijing 100036, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Beijing 100083, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Canc Res Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Wang, You,Liu, Jiangying,Zhao, Hong,et al. Human 1A6/DRIM, the homolog of yeast Utp20, functions in the 18S rRNA processing[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH,2007,1773(6):863-868.
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