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学科主题临床医学
Human 1A6/DRIM, the homolog of yeast Utp20, functions in the 18S rRNA processing
Wang, You; Liu, Jiangying; Zhao, Hong; Lue, Wenqing; Zhao, Jun; Yang, Lin; Li, Ning; Du, Xiaojuan; Ke, Yang
关键词1A6/DRIM UTP20 18S rRNA processing U3 snoRNA
刊名BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
2007-06-01
DOI10.1016/j.bbamcr.2007.04.002
1773期:6页:863-868
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]SMALL NUCLEOLAR RIBONUCLEOPROTEIN ; SMALL-SUBUNIT PROCESSOME ; SMALL NUCLEAR-RNA ; BOX B/C MOTIF ; U3 SNORNP ; GENE-EXPRESSION ; PRE-RIBOSOMES ; CELL-LINES ; PROTEIN ; BIOGENESIS
英文摘要

1A6/DRIM is a nucleolar protein with a nucleolar targeting sequence in its 3′-terminus. Bioinformatic analysis indicated that human 1A6/ DRIM shares 23% identity and 43% similarity with yeast Utp20, which has been reported as a component of U3 snoRNA protein complex and has been implicated in 18S rRNA processing. In the present study, we found, by utilizing RT-PCR with RNA extracted from anti-1A6/DRIM inummoprecipitates and Northern blotting, that 1A6/DRIM is associated with U3 snoRNA. Pulse-chase labeling assays showed that silencing of 1A6/DRIM expression in HeLa cells resulted in a delayed 18S rRNA processing. Furthermore, immunoprecipitations revealed that 1A6/DRIM was also associated with fibrillarin, another U3 RNP component in HeLa cells. These results indicate that 1A6/DRIM is involved in 18S rRNA processing and is the bona fide mammalian Utp20. (c) 2007 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000247495800019
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59100
专题北京大学临床肿瘤学院
作者单位1.Peking Univ, Sch Oncol, Beijing Inst Canc Res, Beijing 100036, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Beijing 100083, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Canc Res Ctr, Beijing 100083, Peoples R China
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GB/T 7714
Wang, You,Liu, Jiangying,Zhao, Hong,et al. Human 1A6/DRIM, the homolog of yeast Utp20, functions in the 18S rRNA processing[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH,2007,1773(6):863-868.
APA Wang, You.,Liu, Jiangying.,Zhao, Hong.,Lue, Wenqing.,Zhao, Jun.,...&Ke, Yang.(2007).Human 1A6/DRIM, the homolog of yeast Utp20, functions in the 18S rRNA processing.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH,1773(6),863-868.
MLA Wang, You,et al."Human 1A6/DRIM, the homolog of yeast Utp20, functions in the 18S rRNA processing".BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1773.6(2007):863-868.
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