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Congenital heart defects and maternal fever: systematic review and meta-analysis
Shi, Q. Y.1; Zhang, J. B.2; Mi, Y. Q.3; Song, Y.4; Ma, J.5; Zhang, Y. L.6,7
刊名JOURNAL OF PERINATOLOGY
2014-09-01
DOI10.1038/jp.2014.76
34期:9页:677-682
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology ; Pediatrics
研究领域[WOS]Obstetrics & Gynecology ; Pediatrics
关键词[WOS]NEURAL-TUBE DEFECTS ; CARDIOVASCULAR MALFORMATIONS ; RISK-FACTORS ; CLINICAL-SIGNIFICANCE ; EARLY-PREGNANCY ; HYPERTHERMIA ; APOPTOSIS ; ABNORMALITIES ; EMBRYOS ; DISEASE
英文摘要

OBJECTIVE: To systematically review and meta-analyze the relation between maternal fever in the first trimester and congenital heart defect (CHD) in offspring.

STUDY DESIGN: We searched PubMed (1977-2012), Embase (1974-2012) and the Cochrane Library (2012) databases to identify relevant articles. Random effects model were performed, with the conduction of subgroup analysis.

RESULT: Meta-analysis yielded a pooled odds ratio of 1.53 (95% confidence interval = 1.36 to 1.73) for the magnitude of the relation between maternal fever in the first trimester and CHD in offspring. As to subgroup analysis, it is associated with ventricular septal defects (VSDs) and right obstructive defects.

CONCLUSION: Our analysis suggests that maternal fever in the first trimester is the risk factor of congenital heart diseases in offspring. Through the subgroup analysis, we find that exposure to maternal fever is the risk factor of VSD and right obstructive defects.

语种英语
WOS记录号WOS:000341403600007
项目编号21003077 ; KLAEMC-OP201101
资助机构National Natural Science Foundation of China ; Key Laboratory of Advanced Energy Materials Chemistry
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59101
专题北京大学公共卫生学院
作者单位1.Tianjin Med Univ, Tianjin Peoples Hosp 2, Grad Sch, Tianjin, Peoples R China
2.Tianjin Med Univ, Tianjin Teda Int Cardiovasc Dis Hosp, Clin Coll Cardiovasc, Tianjin, Peoples R China
3.Tianjin Med Univ, Tianjin Peoples Hosp 2, Dept Chinese Integrat Med, Tianjin, Peoples R China
4.Tianjin Med Univ, Tianjin Teda Int Cardiovasc Dis Hosp, Clin Coll Cardiovasc, Coronary Care Unit, Tianjin, Peoples R China
5.Tianjin Med Univ, Coll Publ Hlth, Dept Hlth Stat, Tianjin 300070, Peoples R China
6.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth,Key Lab Reproduct Hlth, Inst Reprod & Child Hlth,Minist Hlth, Beijing 100871, Peoples R China
7.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Shi, Q. Y.,Zhang, J. B.,Mi, Y. Q.,et al. Congenital heart defects and maternal fever: systematic review and meta-analysis[J]. JOURNAL OF PERINATOLOGY,2014,34(9):677-682.
APA Shi, Q. Y.,Zhang, J. B.,Mi, Y. Q.,Song, Y.,Ma, J.,&Zhang, Y. L..(2014).Congenital heart defects and maternal fever: systematic review and meta-analysis.JOURNAL OF PERINATOLOGY,34(9),677-682.
MLA Shi, Q. Y.,et al."Congenital heart defects and maternal fever: systematic review and meta-analysis".JOURNAL OF PERINATOLOGY 34.9(2014):677-682.
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