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学科主题: 公共卫生
题名:
Congenital heart defects and maternal fever: systematic review and meta-analysis
作者: Shi, Q. Y.1; Zhang, J. B.2; Mi, Y. Q.3; Song, Y.4; Ma, J.5; Zhang, Y. L.6,7
刊名: JOURNAL OF PERINATOLOGY
发表日期: 2014-09-01
DOI: 10.1038/jp.2014.76
卷: 34, 期:9, 页:677-682
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology ; Pediatrics
研究领域[WOS]: Obstetrics & Gynecology ; Pediatrics
关键词[WOS]: NEURAL-TUBE DEFECTS ; CARDIOVASCULAR MALFORMATIONS ; RISK-FACTORS ; CLINICAL-SIGNIFICANCE ; EARLY-PREGNANCY ; HYPERTHERMIA ; APOPTOSIS ; ABNORMALITIES ; EMBRYOS ; DISEASE
英文摘要:

OBJECTIVE: To systematically review and meta-analyze the relation between maternal fever in the first trimester and congenital heart defect (CHD) in offspring.

STUDY DESIGN: We searched PubMed (1977-2012), Embase (1974-2012) and the Cochrane Library (2012) databases to identify relevant articles. Random effects model were performed, with the conduction of subgroup analysis.

RESULT: Meta-analysis yielded a pooled odds ratio of 1.53 (95% confidence interval = 1.36 to 1.73) for the magnitude of the relation between maternal fever in the first trimester and CHD in offspring. As to subgroup analysis, it is associated with ventricular septal defects (VSDs) and right obstructive defects.

CONCLUSION: Our analysis suggests that maternal fever in the first trimester is the risk factor of congenital heart diseases in offspring. Through the subgroup analysis, we find that exposure to maternal fever is the risk factor of VSD and right obstructive defects.

语种: 英语
所属项目编号: 21003077 ; KLAEMC-OP201101
项目资助者: National Natural Science Foundation of China ; Key Laboratory of Advanced Energy Materials Chemistry
WOS记录号: WOS:000341403600007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59101
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Tianjin Med Univ, Tianjin Peoples Hosp 2, Grad Sch, Tianjin, Peoples R China
2.Tianjin Med Univ, Tianjin Teda Int Cardiovasc Dis Hosp, Clin Coll Cardiovasc, Tianjin, Peoples R China
3.Tianjin Med Univ, Tianjin Peoples Hosp 2, Dept Chinese Integrat Med, Tianjin, Peoples R China
4.Tianjin Med Univ, Tianjin Teda Int Cardiovasc Dis Hosp, Clin Coll Cardiovasc, Coronary Care Unit, Tianjin, Peoples R China
5.Tianjin Med Univ, Coll Publ Hlth, Dept Hlth Stat, Tianjin 300070, Peoples R China
6.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth,Key Lab Reproduct Hlth, Inst Reprod & Child Hlth,Minist Hlth, Beijing 100871, Peoples R China
7.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100871, Peoples R China

Recommended Citation:
Shi, Q. Y.,Zhang, J. B.,Mi, Y. Q.,et al. Congenital heart defects and maternal fever: systematic review and meta-analysis[J]. JOURNAL OF PERINATOLOGY,2014,34(9):677-682.
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