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学科主题临床医学
Weekly docetaxel and cisplatin plus fluorouracil as a preoperative treatment for gastric cancer patients with synchronous multiple hepatic metastases: a pilot study
Li, Zi-Yu2; Tang, Lei1; Zhang, Lian-Hai2; Bu, Zhao-De2; Wu, Ai-Wen2; Wu, Xiao-Jiang2; Zong, Xiang-Long2; Wu, Qi2; Shan, Fei2; Li, Shuang-Xi2; Ren, Hui2; Zhang, Xiao-Peng1; Ji, Jia-Fu2
关键词Preoperative chemotherapy Gastric cancer Liver metastasis
刊名MEDICAL ONCOLOGY
2010-12-01
DOI10.1007/s12032-009-9381-y
27期:4页:1314-1318
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者Foundation of Beijing Municipal Committee of Science Technology ; Foundation of Beijing Municipal Committee of Science Technology
研究领域[WOS]Oncology
关键词[WOS]CELL LUNG-CANCER ; PHASE-II TRIAL ; LIVER METASTASES ; RESECTION ; CARCINOMA ; SURVIVAL ; TUMORS
英文摘要

This pilot study was undertaken to assess the effect of weekly docetaxel, cisplatin and fluorouracil (DCF) as a preoperative treatment for gastric cancer with multiple synchronous hepatic metastases. Gastric cancer patients with synchronous multiple liver metastasis were first given preoperative chemotherapy consisting of two courses (each course consisted of 6-week administration and 2-week withdrawal) of weekly DCF regimen. Following the operation, postoperative chemotherapy and hepatic arterial infusion (HAI) treatment were performed as required. Eight patients completed two courses of preoperative chemotherapy with weekly DCF regimen. No toxicity of grade 3 or more was observed during the course of chemotherapy. The response rate was 100% according to the RECIST criteria. Seven of the patients have survived for over 1 year, and six of them are still alive after more than 1 year. Because of the unexpected high response to weekly DCF, we consider that it should be verified through phase II and III trials as an important part of the comprehensive treatment for gastric cancer with liver metastasis.

语种英语
所属项目编号D0905001040631
资助者Foundation of Beijing Municipal Committee of Science Technology ; Foundation of Beijing Municipal Committee of Science Technology
WOS记录号WOS:000284547800047
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59107
专题北京大学临床肿瘤学院
作者单位1.Peking Univ, Key Lab Carcinogenesis & Translat Res, Dept Radiol, Sch Oncol,Beijing Canc Hosp & Inst,Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Key Lab Carcinogenesis & Translat Res, Dept Surg, Sch Oncol,Beijing Canc Hosp & Inst,Minist Educ, Beijing 100142, Peoples R China
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Li, Zi-Yu,Tang, Lei,Zhang, Lian-Hai,et al. Weekly docetaxel and cisplatin plus fluorouracil as a preoperative treatment for gastric cancer patients with synchronous multiple hepatic metastases: a pilot study[J]. MEDICAL ONCOLOGY,2010,27(4):1314-1318.
APA Li, Zi-Yu.,Tang, Lei.,Zhang, Lian-Hai.,Bu, Zhao-De.,Wu, Ai-Wen.,...&Ji, Jia-Fu.(2010).Weekly docetaxel and cisplatin plus fluorouracil as a preoperative treatment for gastric cancer patients with synchronous multiple hepatic metastases: a pilot study.MEDICAL ONCOLOGY,27(4),1314-1318.
MLA Li, Zi-Yu,et al."Weekly docetaxel and cisplatin plus fluorouracil as a preoperative treatment for gastric cancer patients with synchronous multiple hepatic metastases: a pilot study".MEDICAL ONCOLOGY 27.4(2010):1314-1318.
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