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学科主题: 公共卫生
题名:
Analyses of Non-Synonymous Obesity Risk Alleles in SH2B1 (rs7498665) and APOB48R (rs180743) in Obese Children and Adolescents Undergoing a 1-year Lifestyle Intervention
作者: Volckmar, A. -L.1; Puetter, C.2; Song, J. -Y.3,4; Graniger, J.1; Knoll, N.1; Wolters, B.5; Hebebrand, J.1; Scherag, A.2; Reinehr, T.5; Hinney, A.1
关键词: behavioral intervention ; weight loss ; genetics ; APOBR
刊名: EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
发表日期: 2013-06-01
DOI: 10.1055/s-0033-1334875
卷: 121, 期:6, 页:334-337
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: GENOME-WIDE ASSOCIATION ; RECEPTOR GENE ; FOLLOW-UP ; DELETIONS ; WEIGHT ; LOCI ; FAT ; OVERWEIGHT ; VARIANTS ; GLUCOSE
英文摘要:

Introduction: Association of obesity risk alleles of single nucleotide polymorphisms (SNPs) near or in the SH2B adaptor protein 1 gene (SH2B1) and increased body mass index (BMI) has been often described. A gene in close proximity, apolipoprotein B48 receptor gene (APOB48R), is tagged by the same SNP(s).

Material and methods: We analyzed 454 overweight and obese children and adolescents (10.8 +/- 2.6 years, BMI-SDS 2.4 +/- 0.5; 55% girls) who completed a 1-year lifestyle intervention (′Obeldicks′ program). Carriers of obesity risk alleles of non-synonymous SNPs in SH2B1 (rs7498665, Thr484Ala) or APOB48R (rs180743, Pro419Ala), as genotyped by TaqMan, were analysed for changes in anthropometrics (body-mass index (BMI), and standardized BMI (BMI-SDS)), blood pressure (systolic and diastolic) and plasma parameters (total cholesterol, LDL-cholesterol, HDL-cholesterol, triacylglycerides, glucose, insulin, and HOMA).

Results: We observed no evidence for an association of the obesity risk alleles to alterations in any of the analyzed phenotypes. Both mean BMI and BMI-SDS improved during the intervention independent of genotype. The mean systolic blood pressure was lowered and concentrations of HDL-cholesterol increased significantly.

Conclusion: The obesity risk alleles of non-synonymous SNPs at SH2B1 and APOB48R have no strong effect on weight loss-related phenotypes in overweight children after a 1-year lifestyle intervention.

语种: 英语
所属项目编号: 01KU0903 ; NGFNplus: 01GS0820 ; 01GS0822 ; 01GS0830 ; n245009
项目资助者: German Federal Ministry of Education and Research ; EU
WOS记录号: WOS:000320100200003
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59110
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Vest Clin Child & Adolescent Med, Datteln, Germany
2.Univ Duisburg Essen, Dept Child & Adolescent Psychiat, D-45147 Essen, Germany
3.Univ Duisburg Essen, Inst Med Informat Biometry & Epidemiol, D-45147 Essen, Germany
4.Peking Univ, Div Maternal & Child Hlth, Sch Publ Hlth, Hlth Sci Ctr, Beijing 100871, Peoples R China
5.Peking Univ, Key Lab Epidemiol, Minist Educ, Beijing 100871, Peoples R China

Recommended Citation:
Volckmar, A. -L.,Puetter, C.,Song, J. -Y.,et al. Analyses of Non-Synonymous Obesity Risk Alleles in SH2B1 (rs7498665) and APOB48R (rs180743) in Obese Children and Adolescents Undergoing a 1-year Lifestyle Intervention[J]. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES,2013,121(6):334-337.
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