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Analyses of Non-Synonymous Obesity Risk Alleles in SH2B1 (rs7498665) and APOB48R (rs180743) in Obese Children and Adolescents Undergoing a 1-year Lifestyle Intervention
Volckmar, A. -L.1; Puetter, C.2; Song, J. -Y.3,4; Graniger, J.1; Knoll, N.1; Wolters, B.5; Hebebrand, J.1; Scherag, A.2; Reinehr, T.5; Hinney, A.1
关键词behavioral intervention weight loss genetics APOBR
刊名EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
2013-06-01
DOI10.1055/s-0033-1334875
121期:6页:334-337
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]GENOME-WIDE ASSOCIATION ; RECEPTOR GENE ; FOLLOW-UP ; DELETIONS ; WEIGHT ; LOCI ; FAT ; OVERWEIGHT ; VARIANTS ; GLUCOSE
英文摘要

Introduction: Association of obesity risk alleles of single nucleotide polymorphisms (SNPs) near or in the SH2B adaptor protein 1 gene (SH2B1) and increased body mass index (BMI) has been often described. A gene in close proximity, apolipoprotein B48 receptor gene (APOB48R), is tagged by the same SNP(s).

Material and methods: We analyzed 454 overweight and obese children and adolescents (10.8 +/- 2.6 years, BMI-SDS 2.4 +/- 0.5; 55% girls) who completed a 1-year lifestyle intervention (′Obeldicks′ program). Carriers of obesity risk alleles of non-synonymous SNPs in SH2B1 (rs7498665, Thr484Ala) or APOB48R (rs180743, Pro419Ala), as genotyped by TaqMan, were analysed for changes in anthropometrics (body-mass index (BMI), and standardized BMI (BMI-SDS)), blood pressure (systolic and diastolic) and plasma parameters (total cholesterol, LDL-cholesterol, HDL-cholesterol, triacylglycerides, glucose, insulin, and HOMA).

Results: We observed no evidence for an association of the obesity risk alleles to alterations in any of the analyzed phenotypes. Both mean BMI and BMI-SDS improved during the intervention independent of genotype. The mean systolic blood pressure was lowered and concentrations of HDL-cholesterol increased significantly.

Conclusion: The obesity risk alleles of non-synonymous SNPs at SH2B1 and APOB48R have no strong effect on weight loss-related phenotypes in overweight children after a 1-year lifestyle intervention.

语种英语
WOS记录号WOS:000320100200003
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59110
专题北京大学公共卫生学院
作者单位1.Vest Clin Child & Adolescent Med, Datteln, Germany
2.Univ Duisburg Essen, Dept Child & Adolescent Psychiat, D-45147 Essen, Germany
3.Univ Duisburg Essen, Inst Med Informat Biometry & Epidemiol, D-45147 Essen, Germany
4.Peking Univ, Div Maternal & Child Hlth, Sch Publ Hlth, Hlth Sci Ctr, Beijing 100871, Peoples R China
5.Peking Univ, Key Lab Epidemiol, Minist Educ, Beijing 100871, Peoples R China
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Volckmar, A. -L.,Puetter, C.,Song, J. -Y.,et al. Analyses of Non-Synonymous Obesity Risk Alleles in SH2B1 (rs7498665) and APOB48R (rs180743) in Obese Children and Adolescents Undergoing a 1-year Lifestyle Intervention[J]. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES,2013,121(6):334-337.
APA Volckmar, A. -L..,Puetter, C..,Song, J. -Y..,Graniger, J..,Knoll, N..,...&Hinney, A..(2013).Analyses of Non-Synonymous Obesity Risk Alleles in SH2B1 (rs7498665) and APOB48R (rs180743) in Obese Children and Adolescents Undergoing a 1-year Lifestyle Intervention.EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES,121(6),334-337.
MLA Volckmar, A. -L.,et al."Analyses of Non-Synonymous Obesity Risk Alleles in SH2B1 (rs7498665) and APOB48R (rs180743) in Obese Children and Adolescents Undergoing a 1-year Lifestyle Intervention".EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES 121.6(2013):334-337.
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