北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 免疫学系  > 期刊论文
学科主题: 基础医学
题名:
SDF-1 alpha production is negatively regulated by mouse estrogen enhanced transcript in a mouse thymus epithelial cell line
作者: Jin, C; Fu, WX; Xie, LP; Qian, XP; Chen, WF
关键词: SDF-1 alpha ; estrogen ; mouse estrogen enhanced transcript ; NF-kappa B ; thymus stromal cells
刊名: CELLULAR IMMUNOLOGY
发表日期: 2003-05-01
DOI: 10.1016/S0008-8749(03)00152-7
卷: 223, 期:1, 页:26-34
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Immunology
研究领域[WOS]: Cell Biology ; Immunology
关键词[WOS]: NF-KAPPA-B ; ADHESION MOLECULE-1 ; GENE-EXPRESSION ; CHEMOKINES ; 17-BETA-ESTRADIOL ; APOPTOSIS ; CYTOKINES ; MECHANISM ; FACTOR-1 ; PROTEIN
英文摘要:

SDF-1/CXCR4 plays an important role in promoting survival, expansion, and differentiation of T cell progenitors. The present study investigates the mechanism by which estrogen inhibits SDF-1alpha expression in mouse thymus. Mouse estrogen enhanced transcript (mEET) is endogenously expressed in a mouse thymus epithelial cell line I (MTEC1). In MTEC1 cells that express the transfected sense mEET, the SDF-1alpha transcription and its chemotactic activity were profoundly inhibited. Conversely, in MTEC1 that express the transfected anti-sense mEET, the SDF-1alpha transcription and its chemotactic activity were substantially augmented. Moreover, we disclosed that mEET inhibited the production of SDF-1alpha by its suppression of NF-kappaB translocation into nucleus. Using a combinatorial induction of doxycycline (Dox) and 17beta-estradiol (E2) on the sense and anti-sense mEET transfectants, it was demonstrated that an increase of mEET expression enhanced E2-induced inhibition of SDF-1alpha production, while a blockade of mEET expression alleviated E2-induced inhibition of SDF-1alpha production. In conclusion, the E2-imposed suppression of SDF-1alpha production is partly mediated by mEET involved signaling pathway. (C) 2003 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000184948300003
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59118
Appears in Collections:基础医学院_免疫学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
1-s2.0-S0008874903001527-main.pdf(267KB)期刊论文出版稿限制开放 联系获取全文

作者单位: Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China

Recommended Citation:
Jin, C,Fu, WX,Xie, LP,et al. SDF-1 alpha production is negatively regulated by mouse estrogen enhanced transcript in a mouse thymus epithelial cell line[J]. CELLULAR IMMUNOLOGY,2003,223(1):26-34.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Jin, C]'s Articles
[Fu, WX]'s Articles
[Xie, LP]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Jin, C]‘s Articles
[Fu, WX]‘s Articles
[Xie, LP]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace