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学科主题基础医学
SDF-1 alpha production is negatively regulated by mouse estrogen enhanced transcript in a mouse thymus epithelial cell line
Jin, C; Fu, WX; Xie, LP; Qian, XP; Chen, WF
关键词SDF-1 alpha estrogen mouse estrogen enhanced transcript NF-kappa B thymus stromal cells
刊名CELLULAR IMMUNOLOGY
2003-05-01
DOI10.1016/S0008-8749(03)00152-7
223期:1页:26-34
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Immunology
研究领域[WOS]Cell Biology ; Immunology
关键词[WOS]NF-KAPPA-B ; ADHESION MOLECULE-1 ; GENE-EXPRESSION ; CHEMOKINES ; 17-BETA-ESTRADIOL ; APOPTOSIS ; CYTOKINES ; MECHANISM ; FACTOR-1 ; PROTEIN
英文摘要

SDF-1/CXCR4 plays an important role in promoting survival, expansion, and differentiation of T cell progenitors. The present study investigates the mechanism by which estrogen inhibits SDF-1alpha expression in mouse thymus. Mouse estrogen enhanced transcript (mEET) is endogenously expressed in a mouse thymus epithelial cell line I (MTEC1). In MTEC1 cells that express the transfected sense mEET, the SDF-1alpha transcription and its chemotactic activity were profoundly inhibited. Conversely, in MTEC1 that express the transfected anti-sense mEET, the SDF-1alpha transcription and its chemotactic activity were substantially augmented. Moreover, we disclosed that mEET inhibited the production of SDF-1alpha by its suppression of NF-kappaB translocation into nucleus. Using a combinatorial induction of doxycycline (Dox) and 17beta-estradiol (E2) on the sense and anti-sense mEET transfectants, it was demonstrated that an increase of mEET expression enhanced E2-induced inhibition of SDF-1alpha production, while a blockade of mEET expression alleviated E2-induced inhibition of SDF-1alpha production. In conclusion, the E2-imposed suppression of SDF-1alpha production is partly mediated by mEET involved signaling pathway. (C) 2003 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000184948300003
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被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59118
专题北京大学基础医学院_免疫学系
作者单位Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China
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Jin, C,Fu, WX,Xie, LP,et al. SDF-1 alpha production is negatively regulated by mouse estrogen enhanced transcript in a mouse thymus epithelial cell line[J]. CELLULAR IMMUNOLOGY,2003,223(1):26-34.
APA Jin, C,Fu, WX,Xie, LP,Qian, XP,&Chen, WF.(2003).SDF-1 alpha production is negatively regulated by mouse estrogen enhanced transcript in a mouse thymus epithelial cell line.CELLULAR IMMUNOLOGY,223(1),26-34.
MLA Jin, C,et al."SDF-1 alpha production is negatively regulated by mouse estrogen enhanced transcript in a mouse thymus epithelial cell line".CELLULAR IMMUNOLOGY 223.1(2003):26-34.
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