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学科主题: 临床医学
题名:
Association of polymorphisms in vascular endothelial growth factor gene with the age of onset of amyotrophic lateral sclerosis
作者: Chen, Dafang; Shen, Li; Wang, Liping; Lu, Aili; Zhang, Huagang; Zhang, Xiaoyan; Zhang, Yingshuang; Shui, Wei; Li, Linsong; Fan, Dongsheng; Zhang, Jun
关键词: amyotrophic lateral sclerosis ; age onset ; polymorphisms ; vascular endothelial growth factor
刊名: AMYOTROPHIC LATERAL SCLEROSIS
发表日期: 2007
DOI: 10.1080/17482960601179373
卷: 8, 期:3, 页:144-149
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: MOTOR-NEURON DEGENERATION ; PROLONGS SURVIVAL ; FACTOR VEGF ; IN-VITRO ; ALS ; MECHANISMS ; HYPOXIA ; EXPRESSION ; PROMOTER ; DELETION
英文摘要:

This study investigated the association between polymorphisms in vascular endothelial growth factor (VEGF) gene (-1558C-T, - 190A-G and -1154A-G) and age at onset of amyotrophic lateral sclerosis (ALS). Between July 2000 and June 2004 we conducted a clinical genetic study at Peking University Third Hospital, China. The analyses included a total of 93 ALS patients. Genotyping was performed by using the 5′-nuclease assay technology (Applied Biosystems) with TaqMan((R)) allele-specific fluorogenic oligonucleotide probes. We used multivariate linear regression modelling and haplotype-based association test to analyse the association of VEGF gene polymorphisms with the age of onset, adjusting for initial symptoms and sex. The results indicated that patients with the -1190A/G and -1190G/G genotypes exhibited about a 4.1- and 9.4years earlier onset of ALS than the patients with the - 1190A/ A genotype. A similar pattern emerged when the VEGF - 1154A- G gene was considered: the beta was 27.9(p<0.001) years and 211.7(pv0.001) years for -1154A/G and -1154G/G genotypes, respectively. The VEGF -1558C-T had a positive effect in the -1558C/T group (p50.007, b57.0) and -1558T/ T (pv0.001, b59.6) compared to the - 1558C/C group. We neither observed an interaction nor haplotype association with age onset among - 1558C-T, -1190A-G and -1154A-G. In conclusion, our results indicate, for the first time, that there was an important association between the polymorphism of the VEGF gene and age of ALS onset. This suggests a possible role for VEGF variability in the aetiology of individual differences in ALS onset.

语种: 英语
WOS记录号: WOS:000246949600002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59119
Appears in Collections:北京大学第三临床医学院_神经内科_期刊论文

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作者单位: 1.Peking Univ, Stem Cell Res Ctr, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 3, Dept Neurol, Beijing 100083, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Stat, Beijing 100871, Peoples R China

Recommended Citation:
Chen, Dafang,Shen, Li,Wang, Liping,et al. Association of polymorphisms in vascular endothelial growth factor gene with the age of onset of amyotrophic lateral sclerosis[J]. AMYOTROPHIC LATERAL SCLEROSIS,2007,8(3):144-149.
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