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学科主题临床医学
Association of polymorphisms in vascular endothelial growth factor gene with the age of onset of amyotrophic lateral sclerosis
Chen, Dafang; Shen, Li; Wang, Liping; Lu, Aili; Zhang, Huagang; Zhang, Xiaoyan; Zhang, Yingshuang; Shui, Wei; Li, Linsong; Fan, Dongsheng; Zhang, Jun
关键词amyotrophic lateral sclerosis age onset polymorphisms vascular endothelial growth factor
刊名AMYOTROPHIC LATERAL SCLEROSIS
2007
DOI10.1080/17482960601179373
8期:3页:144-149
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]MOTOR-NEURON DEGENERATION ; PROLONGS SURVIVAL ; FACTOR VEGF ; IN-VITRO ; ALS ; MECHANISMS ; HYPOXIA ; EXPRESSION ; PROMOTER ; DELETION
英文摘要

This study investigated the association between polymorphisms in vascular endothelial growth factor (VEGF) gene (-1558C-T, - 190A-G and -1154A-G) and age at onset of amyotrophic lateral sclerosis (ALS). Between July 2000 and June 2004 we conducted a clinical genetic study at Peking University Third Hospital, China. The analyses included a total of 93 ALS patients. Genotyping was performed by using the 5′-nuclease assay technology (Applied Biosystems) with TaqMan((R)) allele-specific fluorogenic oligonucleotide probes. We used multivariate linear regression modelling and haplotype-based association test to analyse the association of VEGF gene polymorphisms with the age of onset, adjusting for initial symptoms and sex. The results indicated that patients with the -1190A/G and -1190G/G genotypes exhibited about a 4.1- and 9.4years earlier onset of ALS than the patients with the - 1190A/ A genotype. A similar pattern emerged when the VEGF - 1154A- G gene was considered: the beta was 27.9(p<0.001) years and 211.7(pv0.001) years for -1154A/G and -1154G/G genotypes, respectively. The VEGF -1558C-T had a positive effect in the -1558C/T group (p50.007, b57.0) and -1558T/ T (pv0.001, b59.6) compared to the - 1558C/C group. We neither observed an interaction nor haplotype association with age onset among - 1558C-T, -1190A-G and -1154A-G. In conclusion, our results indicate, for the first time, that there was an important association between the polymorphism of the VEGF gene and age of ALS onset. This suggests a possible role for VEGF variability in the aetiology of individual differences in ALS onset.

语种英语
WOS记录号WOS:000246949600002
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59119
专题北京大学第三临床医学院_神经内科
作者单位1.Peking Univ, Stem Cell Res Ctr, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 3, Dept Neurol, Beijing 100083, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Stat, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Chen, Dafang,Shen, Li,Wang, Liping,et al. Association of polymorphisms in vascular endothelial growth factor gene with the age of onset of amyotrophic lateral sclerosis[J]. AMYOTROPHIC LATERAL SCLEROSIS,2007,8(3):144-149.
APA Chen, Dafang.,Shen, Li.,Wang, Liping.,Lu, Aili.,Zhang, Huagang.,...&Zhang, Jun.(2007).Association of polymorphisms in vascular endothelial growth factor gene with the age of onset of amyotrophic lateral sclerosis.AMYOTROPHIC LATERAL SCLEROSIS,8(3),144-149.
MLA Chen, Dafang,et al."Association of polymorphisms in vascular endothelial growth factor gene with the age of onset of amyotrophic lateral sclerosis".AMYOTROPHIC LATERAL SCLEROSIS 8.3(2007):144-149.
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