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学科主题: 药学
题名:
Glycycoumarin ameliorates alcohol-induced hepatotoxicity via activation of Nrf2 and autophagy
作者: Song, Xinhua1; Yin, Shutao1; Huo, Yazhen1; Liang, Min1; Fan, Lihong2; Ye, Min3; Hu, Hongbo1
关键词: Alcoholic liver injury ; Licorice ; Glycycoumarin ; Nrf2 ; Autophagy ; Free radicals
刊名: FREE RADICAL BIOLOGY AND MEDICINE
发表日期: 2015-12-01
DOI: 10.1016/j.freeradbiomed.2015.07.006
卷: 89, 页:135-146
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Endocrinology & Metabolism
研究领域[WOS]: Biochemistry & Molecular Biology ; Endocrinology & Metabolism
关键词[WOS]: TRANSCRIPTION FACTOR NRF2 ; GLYCYRRHIZA-URALENSIS ; SELECTIVE AUTOPHAGY ; OXIDATIVE STRESS ; HERBAL MEDICINE ; LIVER-DISEASES ; P62 ; PROTEIN ; ANTIOXIDANT ; FLAVONOIDS
英文摘要:

Licorice, a traditional Chinese medicine, has been used to treat various diseases, including liver disease, for centuries. However, the chemical basis and biological mechanisms underlying the biological functions of licorice remain elusive. The purpose of the current study was to test the hepatoprotective effect of glycycoumarin (GCM), a representative coumarin in licorice, using animal models of both chronic and acute alcoholic liver injury. C57BL/6J mice were used to evaluate the hepatoprotective effect of GCM on liver injury induced by either chronic or acute ethanol exposure. AML-12 and HepG2 cells were utilized to determine the functional role of Nrf2 in the hepatoprotective effect of GCM and to decipher the mechanisms of GCM-induced Nrf2 activation. We found that treatment with GCM leads to a significant reduction in hepatotoxicity in response to either chronic or acute ethanol exposure. Further mechanistic investigations reveal that activation of Nrf2 via the p38 pathway and induction of autophagy by GCM contribute to its hepatoprotective activity. In addition, we demonstrate that p62 upregulation by a transcriptional mechanism also contributes to Nrf2 activation via a positive feedback loop. Our study has identified GCM as a novel active ingredient that contributes to the hepatoprotective activity of licorice. (C) 2015 Published by Elsevier Inc.

语种: 英语
所属项目编号: 2012BAD33B09
项目资助者: Ministry of Science and Technology of China
WOS记录号: WOS:000366355800013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/59120
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.China Agr Univ, Coll Food Sci & Nutr Engn, Dept Nutr & Hlth, Beijing 100083, Peoples R China
2.China Agr Univ, Coll Vet Med, Beijing 100193, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Song, Xinhua,Yin, Shutao,Huo, Yazhen,et al. Glycycoumarin ameliorates alcohol-induced hepatotoxicity via activation of Nrf2 and autophagy[J]. FREE RADICAL BIOLOGY AND MEDICINE,2015,89:135-146.
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