学科主题临床医学
In vitro enhancement of dendritic cell-mediated anti-glioma immune response by graphene oxide
Wang, Wei1,2,3; Li, Zhongjun4; Duan, Jinhong2,3; Wang, Chen4; Fang, Ying4; Yang, Xian-Da2,3
关键词Glioma Dendritic cell DC Graphene oxide GO Immunotherapy
刊名NANOSCALE RESEARCH LETTERS
2014-06-20
DOI10.1186/1556-276X-9-311
9
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
研究领域[WOS]Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]MALIGNANT GLIOMA ; SURVIVIN ; PROTEIN ; VACCINATION ; EXPRESSION ; IDENTIFICATION ; GLIOBLASTOMA ; INHIBITOR ; DELIVERY ; LYSATE
英文摘要

Malignant glioma has extremely poor prognosis despite combination treatments with surgery, radiation, and chemotherapy. Dendritic cell (DC)-based immunotherapy may potentially serve as an adjuvant treatment of glioma, but its efficacy generally needs further improvement. Here we explored whether graphene oxide (GO) nanosheets could modulate the DC-mediated anti-glioma immune response in vitro, using the T98G human glioma cell line as the study model. Pulsing DCs with a glioma peptide antigen (Ag) generated a limited anti-glioma response compared to un-pulsed DCs. Pulsing DCs with GO alone failed to produce obvious immune modulation effects. However, stimulating DCs with a mixture of GO and Ag (GO-Ag) significantly enhanced the anti-glioma immune reaction (p < 0.05). The secretion of interferon gamma (IFN-gamma) by the lymphocytes was also markedly boosted by GO-Ag. Additionally, the anti-glioma immune response induced by GO-Ag appeared to be target-specific. Furthermore, at the concentration used in this study, GO exhibited a negligible effect on the viability of the DCs. These results suggested that GO might have potential utility for boosting a DC-mediated anti-glioma immune response.

语种英语
WOS记录号WOS:000339346300001
项目编号81071870 ; 2011CB933504 ; 21173055 ; 21161120321 ; RDB2012-08
资助机构Natural Science Foundation of China (NSFC) ; Chinese Ministry of Science and Technology ; NSFC ; Peking University People&prime ; s Hospital Research and Development Funds
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/59124
专题北京大学第二临床医学院_北京大学肝病研究所
作者单位1.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing 100044, Peoples R China
2.Chinese Acad Med Sci, Inst Basic Med Sci, Beijing 100005, Peoples R China
3.Peking Union Med Coll, Beijing 100005, Peoples R China
4.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
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GB/T 7714
Wang, Wei,Li, Zhongjun,Duan, Jinhong,et al. In vitro enhancement of dendritic cell-mediated anti-glioma immune response by graphene oxide[J]. NANOSCALE RESEARCH LETTERS,2014,9.
APA Wang, Wei,Li, Zhongjun,Duan, Jinhong,Wang, Chen,Fang, Ying,&Yang, Xian-Da.(2014).In vitro enhancement of dendritic cell-mediated anti-glioma immune response by graphene oxide.NANOSCALE RESEARCH LETTERS,9.
MLA Wang, Wei,et al."In vitro enhancement of dendritic cell-mediated anti-glioma immune response by graphene oxide".NANOSCALE RESEARCH LETTERS 9(2014).
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